Search Results - "Cynshi, Osamu"

An orally active motilin receptor antagonist, MA-2029, inhibits motilin-induced gastrointestinal motility, increase in fundic tone, and diarrhea in conscious dogs without affecting gastric emptying by Ozaki, Ken-ichi, Onoma, Mitsu, Muramatsu, Hiroyasu, Sudo, Hirokazu, Yoshida, Shoshin, Shiokawa, Rie, Yogo, Kenji, Kamei, Kenshi, Cynshi, Osamu, Kuromaru, Osamu, Peeters, Theo L., Takanashi, Hisanori

“…The pharmacological properties of MA-2029, a selective and competitive motilin receptor antagonist, were investigated in conscious dogs after oral…”
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Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE by Yoshida, Yasukazu, Itoh, Nanako, Hayakawa, Mieko, Piga, Rosaria, Cynshi, Osamu, Jishage, Kou-ichi, Niki, Etsuo

“…We have recently proposed total hydroxyoctadecadienoic acid (HODE) as a biomarker for oxidative stress in vivo. The biological samples such as plasma, urine,…”
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Oral administration of MA-2029, a novel selective and competitive motilin receptor antagonist, inhibits motilin-induced intestinal contractions and visceral pain in rabbits by Sudo, Hirokazu, Yoshida, Shoshin, Ozaki, Ken-ichi, Muramatsu, Hiroyasu, Onoma, Mitsu, Yogo, Kenji, Kamei, Kenshi, Cynshi, Osamu, Kuromaru, Osamu, Peeters, Theo L., Takanashi, Hisanori

“…The pharmacological properties of MA-2029, a novel motilin receptor antagonist, were investigated. In vitro, MA-2029 (1 to 30 nM) competitively inhibited…”
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Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid by Yoshida, Yasukazu, Itoh, Nanako, Hayakawa, Mieko, Habuchi, Yoko, Inoue, Ruriko, Chen, Zhi-Hua, Cao, Jiaofei, Cynshi, Osamu, Niki, Etsuo

“…The relevance of oxidative stress in mice fed a choline-deficient diet (CDD) was investigated in relation to the oxidative stress marker,…”
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Design and Synthesis of 4,6-Di-tert-butyl-2,3-dihydro-5-benzofuranols as a Novel Series of Antiatherogenic Antioxidants by Tamura, Kunio, Kato, Yoshiaki, Ishikawa, Akira, Kato, Yasuharu, Himori, Motomu, Yoshida, Mitsutaka, Takashima, Yoshiaki, Suzuki, Tsukasa, Kawabe, Yoshiki, Cynshi, Osamu, Kodama, Tatsuhiko, Niki, Etsuo, Shimizu, Makoto

“…Antioxidants have been considered as potential antiatherogenic agents by inhibiting oxidation of low-density lipoprotein (LDL), albeit vitamin E, a natural…”
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Stability and Reactivity of Aryloxyl Radicals Derived from a Novel Antioxidant BO-653 and Related Compounds. Effects of Substituent and Side Chain in Solution and Membranes by Watanabe, Akira, Noguchi, Noriko, Fujisawa, Akio, Kodama, Tatsuhiko, Tamura, Kunio, Cynshi, Osamu, Niki, Etsuo

“…2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran (BO-653) is a novel antioxidant designed as a drug for inhibition of lipid peroxidation in vivo…”
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Acceleration of lipid peroxidation in alpha-tocopherol transfer protein-knockout mice following the consumption of drinking water containing a radical initiator by Yoshida, Yasukazu, Hayakawa, Mieko, Cynshi, Osamu, Jishage, Kou-ichi, Niki, Etsuo

“…To assess the antioxidative role of vitamin E (VE) in a mouse model of severe VE deficiency by using biomarkers, alpha-tocopherol transfer protein…”
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Antiatherogenic Effects of the Antioxidant BO-653 in Three Different Animal Models by Cynshi, Osamu, Kawabe, Yoshiki, Suzuki, Tsukasa, Takashima, Yoshiaki, Kaise, Hiroshi, Nakamura, Minako, Ohba, Yasuhiro, Kato, Yoshiaki, Tamura, Kunio, Hayasaka, Akira, Higashida, Atsuko, Sakaguchi, Hisashi, Takeya, Motohiro, Takahashi, Kiyoshi, Inoue, Kenji, Noguchi, Noriko, Niki, Etsuo, Kodama, Tatsuhiko

“…Antioxidants have been proposed to have antiatherogenic potential by their inhibition of low density lipoprotein (LDL) oxidation. Here, we report an…”
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Inhibition of Oxidation of Low-Density Lipoprotein by a Novel Antioxidant, BO-653, Prepared by Theoretical Design by Noguchi, Noriko, Okimoto, Yuko, Tsuchiya, Jyunichi, Cynshi, Osamu, Kodama, Tatsuhiko, Niki, Etsuo

“…2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butyl-benzofuran (BO-653) is a novel antioxidant synthesized by theoretical designing based on the previous…”
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Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits by Inoue, Kenji, Cynshi, Osamu, Kawabe, Yoshiki, Nakamura, Minako, Miyauchi, Katsumi, Kimura, Tohoru, Daida, Hiroyuki, Hamakubo, Takao, Yamaguchi, Hiroshi, Kodama, Tatsuhiko

“…Antioxidants have been proposed as a promising treatment for restenosis after percutaneous transluminal coronary angioplasty (PTCA), but their mechanism of…”
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Motilides: A long and winding road. Lessons from mitemcinal (GM-611) on diabetic gastroparesis by TAKANASHI, Hisanori, CVNSHI, Osamu

“…Mitemcinal (GM-611) is a macrolide motilin receptor agonist with acid-resistance and without antibiotic activity. Since ABT-229 (a first generation of motilin…”
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Motilides: A long and winding road by Takanashi, Hisanori, Cynshi, Osamu

“…Mitemcinal (GM-611) is a macrolide motilin receptor agonist with acid-resistance and without antibiotic activity. Since ABT-229 (a first generation of motilin…”
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Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency by Suarna, Cacang, Wu, Ben J., Choy, Katherine, Mori, Trevor, Croft, Kevin, Cynshi, Osamu, Stocker, Roland

“…Vitamin E has failed to protect humans from cardiovascular disease outcome, yet its role in experimental atherosclerosis remains less clear. A previous study (…”
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Acceleration of age-related changes in the retina in α-tocopherol transfer protein null mice fed a vitamin E-deficient diet by TANITO, Masaki, YOSHIDA, Yasukazu, KAIDZU, Sachiko, CHEN, Zhi-Hua, CYNSHI, Osamu, JISHAGE, Kou-Ichi, NIKI, Etsuo, OHIRA, Akihiro

“…To assess the role of vitamin E (VE) in age-related changes in the retinal tissues by using a mouse model of severe VE deficiency. Pups of alpha-tocopherol…”
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The role of α-tocopherol in motor hypofunction with aging in α-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers by Yoshida, Yasukazu, Itoh, Nanako, Hayakawa, Mieko, Habuchi, Yoko, Saito, Yoshiro, Tsukamoto, Yoshitane, Cynshi, Osamu, Jishage, Kou-ichi, Arai, Hiroyuki, Niki, Etsuo

“…It has been hypothesized that oxidative stress plays a key role in aging. In order to elucidate the role of the antioxidant network — including α-tocopherol…”
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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection by Suzuki, Hiroshi, Kurihara, Yukiko, Takeya, Motohiro, Kamada, Nobuo, Kataoka, Motoyukl, Jishage, Kouichi, Ueda, Otoya, Sakaguchi, Hisashl, Higashi, Takayuki, Suzuki, Tsukasa, Takashima, Yoshiaki, Kawabe, Yoshiki, Cynshi, Osamu, Wada, Youichiro, Honda, Makoto, Kurihara, Hiroki, Aburatani, Hiroyuki, Doi, Takefumi, Matsumoto, Akiyo, Azuma, Sadahiro, Noda, Tetsuo, Toyoda, Yutaka, Itakura, Hiroshige, Yazaki, Yoshio, Horiuchi, Seikoh, Takahashi, Kiyoshi, Kruijt, J. Kar, van Berkel, Theo J. C, Steinbrecher, Urs P, Ishibashi, Shun, Maeda, Nobuyo, Gordon, Siamon, Kodama, Tatsuhiko

“…Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result…”
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γ-Tocopherol attenuates MPTP-induced dopamine loss more efficiently than α-tocopherol in mouse brain by Itoh, Nanako, Masuo, Yoshinori, Yoshida, Yasukazu, Cynshi, Osamu, Jishage, Kou-ichi, Niki, Etsuo

“…Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse has been widely used as a rodent model of Parkinson's disease. In this study, α-tocopherol (αT)…”
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Characterization of aggregated low density lipoproteins induced by copper-catalyzed oxidation by Cynshi, O, Takashima, Y, Suzuki, T, Kawabe, Y, Ohba, Y, Kodama, T

“…Oxidation of low density lipoproteins (LDL) has been shown to lead to enhanced uptake by macrophages mediated by the scavenger receptor. In the present study,…”
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Design, synthesis, and action of antiatherogenic antioxidants by Cynshi, Osamu, Tamura, Kunio, Niki, Etsuo

“…Ample evidence supports the critical role of oxidized low-density lipoprotein (ox-LDL) in initiation and progression of atherosclerosis. Oxidation of LDL is a…”
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The role of a-tocopherol in motor hypofunction with aging in a-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers by Yoshida, Yasukazu, Itoh, Nanako, Hayakawa, Mieko, Habuchi, Yoko, Saito, Yoshiro, Tsukamoto, Yoshitane, Cynshi, Osamu, Jishage, Kou-Ichi, Arai, Hiroyuki, Niki, Etsuo

“…It has been hypothesized that oxidative stress plays a key role in aging. In order to elucidate the role of the antioxidant network - including a-tocopherol…”
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