Search Results - "Cwetsch, Andrzej W"

The development of synaptic transmission is time-locked to early social behaviors in rats by Naskar, Shovan, Narducci, Roberto, Balzani, Edoardo, Cwetsch, Andrzej W., Tucci, Valter, Cancedda, Laura

“…The development of functional synapses is a sequential process preserved across many brain areas. Here, we show that glutamatergic postsynaptic currents…”
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The X-Linked Intellectual Disability Protein IL1RAPL1 Regulates Dendrite Complexity by Montani, Caterina, Ramos-Brossier, Mariana, Ponzoni, Luisa, Gritti, Laura, Cwetsch, Andrzej W, Braida, Daniela, Saillour, Yoann, Terragni, Benedetta, Mantegazza, Massimo, Sala, Mariaelvina, Verpelli, Chiara, Billuart, Pierre, Sala, Carlo

“…Mutations and deletions of the ( ) gene, located on the X chromosome, are associated with intellectual disability (ID) and autism spectrum disorder (ASD)…”
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Modelling genetic mosaicism of neurodevelopmental disorders in vivo by a Cre-amplifying fluorescent reporter by Trovato, Francesco, Parra, Riccardo, Pracucci, Enrico, Landi, Silvia, Cozzolino, Olga, Nardi, Gabriele, Cruciani, Federica, Pillai, Vinoshene, Mosti, Laura, Cwetsch, Andrzej W., Cancedda, Laura, Gritti, Laura, Sala, Carlo, Verpelli, Chiara, Maset, Andrea, Lodovichi, Claudia, Ratto, Gian Michele

“…Genetic mosaicism, a condition in which an organ includes cells with different genotypes, is frequently present in monogenic diseases of the central nervous…”
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Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex by Arai, Yoko, Cwetsch, Andrzej W., Coppola, Eva, Cipriani, Sara, Nishihara, Hidenori, Kanki, Hiroaki, Saillour, Yoann, Freret-Hodara, Betty, Dutriaux, Annie, Okada, Norihiro, Okano, Hideyuki, Dehay, Colette, Nardelli, Jeannette, Gressens, Pierre, Shimogori, Tomomi, D’Onofrio, Giuseppe, Pierani, Alessandra

“…Changes in transcriptional regulation through cis-regulatory elements are thought to drive brain evolution. However, how this impacts the identity of primate…”
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Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias by González-Martínez, José, Cwetsch, Andrzej W, Martínez-Alonso, Diego, López-Sainz, Luis R, Almagro, Jorge, Melati, Anna, Gómez, Jesús, Pérez-Martínez, Manuel, Megías, Diego, Boskovic, Jasminka, Gilabert-Juan, Javier, Graña-Castro, Osvaldo, Pierani, Alessandra, Behrens, Axel, Ortega, Sagrario, Malumbres, Marcos

“…Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal…”
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Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition by Moreau, Matthieu X., Saillour, Yoann, Cwetsch, Andrzej W., Pierani, Alessandra, Causeret, Frédéric

“…ABSTRACT In the developing cerebral cortex, how progenitors that seemingly display limited diversity end up producing a vast array of neurons remains a…”
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Targeted in vivo genetic manipulation of the mouse or rat brain by in utero electroporation with a triple-electrode probe by Szczurkowska, Joanna, Cwetsch, Andrzej W, dal Maschio, Marco, Ghezzi, Diego, Ratto, Gian Michele, Cancedda, Laura

“…This protocol extension describes how to electroporate rodent neuronal progenitors in utero with greater accuracy by using triple-electrode probes. This…”
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In vivo methods for acute modulation of gene expression in the central nervous system by Cwetsch, Andrzej W, Pinto, Bruno, Savardi, Annalisa, Cancedda, Laura

“…Accurate and timely expression of specific genes guarantees the healthy development and function of the brain. Indeed, variations in the correct amount or…”
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The female epilepsy protein PCDH19 is a new GABAAR-binding partner that regulates GABAergic transmission as well as migration and morphological maturation of hippocampal neurons by Bassani, Silvia, Cwetsch, Andrzej W, Gerosa, Laura, Serratto, Giulia M, Folci, Alessandra, Hall, Ignacio F, Mazzanti, Michele, Cancedda, Laura, Passafaro, Maria

“…Abstract The PCDH19 gene (Xp22.1) encodes the cell-adhesion protein protocadherin-19 (PCDH19) and is responsible for a neurodevelopmental pathology…”
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Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division by González-Martínez, José, Cwetsch, Andrzej W., Gilabert-Juan, Javier, Gómez, Jesús, Garaulet, Guillermo, Schneider, Paulina, de Cárcer, Guillermo, Mulero, Francisca, Caleiras, Eduardo, Megías, Diego, Porlan, Eva, Malumbres, Marcos

“…Alteration of centrosome function and dynamics results in major defects during chromosome segregation and is associated with primary autosomal microcephaly…”
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Synaptogenesis Stimulates a Proteasome-Mediated Ribosome Reduction in Axons by Costa, Rui O., Martins, Helena, Martins, Luís F., Cwetsch, Andrzej W., Mele, Miranda, Pedro, Joana R., Tomé, Diogo, Jeon, Noo Li, Cancedda, Laura, Jaffrey, Samie R., Almeida, Ramiro D.

“…Ribosomes and a subset of cellular mRNAs are trafficked into axons of developing neurons. The axonal localization of translational machinery allows new…”
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A Localized Scaffold for cGMP Increase Is Required for Apical Dendrite Development by Szczurkowska, Joanna, Lee, Seong-Il, Guo, Alan, Cwetsch, Andrzej W., Khan, Tanvir, Rao, Sneha, Walz, Gerd, Huber, Tobias B., Cancedda, Laura, Pautot, Sophie, Shelly, Maya

“…Studies in cultured neurons have established that axon specification instructs neuronal polarization and is necessary for dendrite development. However,…”
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A rat model of a focal mosaic expression of PCDH19 replicates human brain developmental abnormalities and behaviours by Cwetsch, Andrzej W., Ziogas, Ilias, Narducci, Roberto, Savardi, Annalisa, Bolla, Maria, Pinto, Bruno, Perlini, Laura E., Bassani, Silvia, Passafaro, Maria, Cancedda, Laura

“…Abstract Protocadherin 19 gene-related epilepsy or protocadherin 19 clustering epilepsy is an infantile-onset epilepsy syndrome characterized by psychiatric…”
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Apaf1-deficient cortical neurons exhibit defects in axonal outgrowth by De Zio, Daniela, Molinari, Francesca, Rizza, Salvatore, Gatta, Lucia, Ciotti, Maria Teresa, Salvatore, Anna Maria, Mathiassen, Søs Grønbæk, Cwetsch, Andrzej W., Filomeni, Giuseppe, Rosano, Giuseppe, Ferraro, Elisabetta

“…The establishment of neuronal polarity and axonal outgrowth are key processes affecting neuronal migration and synapse formation, their impairment likely…”
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CROSSTALK BETWEEN PROTOCADHERIN 8 AND TRANSCRIPTION FACTOR DBX1 REGULATE CELL FATE IN THE DEVELOPING CEREBRAL CORTEX by Cwetsch, Andrzej W, Gilabert-Juan, Javier, Ferreira, Sofia, Moreau, Matthieu, Saillour, Yoann, Delberghe, Elodie, Martínez, Jose González, Nedelec, Stephen, Borello, Ugo, Thomas, Sophie, Causeret, Frederic, Pierani, Alessandra

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Increased performance in genetic manipulation by modeling the dielectric properties of the rodent brain by Szczurkowska, Joanna, dal Maschio, Marco, Cwetsch, Andrzej W., Ghezzi, Diego, Bony, Guillaume, Alabastri, Alessandro, Zaccaria, Remo Proietti, di Fabrizio, Enzo, Ratto, Gian Michele, Cancedda, Laura

“…Genetic approaches to control DNA expression in different brain areas have provided an excellent system to characterize gene function in health and disease of…”
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