Search Results - "Cvek, Boris"

Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells by Skrott, Zdenek, Cvek, Boris

“…The idea of "repurposing" of existing drugs provides an effective way to develop and identify new therapies. Disulfiram (Antabuse), a drug commonly used for…”
Get more information

The Raffles Dialogue on Human Wellbeing and Security by Cvek, Boris

Get full text

Ni(II), Cu(II), and Zn(II) Diethyldithiocarbamate Complexes Show Various Activities Against the Proteasome in Breast Cancer Cells by Cvek, Boris, Milacic, Vesna, Taraba, Jan, Dou, Q. Ping

“…A series of three complexes with diethyldithiocarbamate ligand and three different metals (Ni, Cu, Zn) was prepared, confirmed by X-ray crystallography, and…”
Get full text

The ubiquitin-proteasome system (UPS) and the mechanism of action of bortezomib by Cvek, Boris, Dvorak, Zdenek

“…Proteasome inhibition is a modern and surprisingly successful approach how to cancer treatment. Bortezomib (Velcade®) is a first-in-class proteasome inhibitor…”
Get more information

The value of proteasome inhibition in cancer by Cvek, Boris, Dvorak, Zdenek

“…The major approach to the development of anticancer drugs involves searching for new compounds, efficient against malignancies, which are not, as yet, used…”
Get full text

Failure of ditiocarb (diethyldithiocarbamate) therapy: was diet the reason? by Cvek, Boris

Get more information

Multiple deadlocks in the development of nonprofit drugs by Cvek, Boris

“…•The case of dexamethasone has shown that development of unpatentable drug for new indication is possible in the real world.•Organization, administration and…”
Get full text

Nonprofit drugs as the salvation of the world's healthcare systems: the case of Antabuse (disulfiram) by Cvek, Boris

“…The effort to repurpose old drugs for new uses is not sufficient; even drugs that have been used clinically for decades must undergo expensive clinical trials…”
Get full text

The Promiscuity of Disulfiram in Medicinal Research by Cvek, Boris

“…Recent efforts to repurpose disulfiram, a drug used in alcohol-aversion therapy for decades, for other diseases suggest the molecule is almost an in vitro…”
Get full text

Searching for Positive Side Effects of Common Drugs by Cvek, Boris

Get full text

Promoting Medical Innovation by Cvek, Boris

Get full text

Drug Repurposing for Terminal-Stage Cancer Patients by Cvek, Boris

“…I have read with great interest "The Myth Regarding the High Cost of End-of-Life Care" by Aldridge and Kelley.1 Using a case, recently published by Nature, of…”
Get full text

Low-Income Countries And Repurposed Drugs by Cvek, Boris

Get full text

Antabuse (disulfiram) as a pilot case of nonprofit drug by Cvek, Boris

Get full text

Antabuse repurposing: We need more knowledge and wide international support by Cvek, Boris

Get full text

The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor? by Cvek, Boris, Dvorak, Zdenek

“…The major approach to the development of anticancer drugs involves searching for new compounds, efficient against malignancies, which are not, as yet, used…”
Get full text

Dithiocarbamate complexes with metals in cancer therapy by Cvek, Boris

Get more information

Proteasome Inhibitors by Cvek, Boris

“…In May 2003, the US Food and Drug Administration (FDA) granted accelerated approval for the use of the first-in-class proteasome inhibitor bortezomib as a…”
Get full text

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 by Skrott, Zdenek, Mistrik, Martin, Andersen, Klaus Kaae, Friis, Søren, Majera, Dusana, Gursky, Jan, Ozdian, Tomas, Bartkova, Jirina, Turi, Zsofia, Moudry, Pavel, Kraus, Marianne, Michalova, Martina, Vaclavkova, Jana, Dzubak, Petr, Vrobel, Ivo, Pouckova, Pavla, Sedlacek, Jindrich, Miklovicova, Andrea, Kutt, Anne, Li, Jing, Mattova, Jana, Driessen, Christoph, Dou, Q. Ping, Olsen, Jørgen, Hajduch, Marian, Cvek, Boris, Deshaies, Raymond J., Bartek, Jiri

“…Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need…”
Get full text

Linking the activity of bortezomib in multiple myeloma and autoimmune diseases by Škrott, Zdeněk, Cvek, Boris

“…Abstract Since their introduction to the clinic 10 years ago, proteasome inhibitors have become the cornerstone of anti-multiple myeloma therapy. Despite…”
Get full text