Search Results - "Cuzzoni, Eva"
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Reappraisal of Antimalarials in Interferonopathies: New Perspectives for Old Drugs
Published in Current medicinal chemistry (01-01-2018)“…The story of antimalarials as antinflammatory drugs dates back several centuries. Chinin, the extract of the Cinchona bark, has been exploited since the 18th…”
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Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase?
Published in World journal of gastroenterology : WJG (07-04-2014)“…Azathioprine is a purine antimetabolite drug commonly used to treat inflammatory bowel disease(IBD).In vivo it is active after reaction with reduced…”
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Hypomethylation of NLRP3 gene promoter discriminates glucocorticoid‐resistant from glucocorticoid‐sensitive idiopathic nephrotic syndrome patients
Published in Clinical and translational science (01-05-2021)“…To assess whether NLRP3 gene promoter methylation was able to discriminate glucocorticoid (GC)‐resistant from GC‐sensitive idiopathic nephrotic syndrome (INS),…”
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Fate of lymphocytes after withdrawal of tofacitinib treatment
Published in PloS one (09-01-2014)“…Tofacitinib (Tofa) is an inhibitor of Janus Kinase 3, developed for the treatment of autoimmune diseases and for the prevention of transplant rejection. Due to…”
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Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn’s disease
Published in World journal of gastroenterology : WJG (14-04-2015)“…Mesenchymal stem cells(MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro.It has recently been observed…”
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Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease:Effect of N-acetyl transferase polymorphisms
Published in World journal of gastroenterology : WJG (28-03-2015)“…AIM: To evaluate variation of the concentration of thiopurine metabolites after 5-aminosalicylate(5-ASA) interruption and the role of genetic polymorphisms of…”
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Causes of Treatment Failure in Children With Inflammatory Bowel Disease Treated With Infliximab: A Pharmacokinetic Study
Published in Journal of pediatric gastroenterology and nutrition (01-01-2019)“…OBJECTIVES:Anti-tumor necrosis factor antibodies have led to a revolution in the treatment of inflammatory bowel diseases (IBD); however, a sizable proportion…”
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MIF plasma level as a possible tool to predict steroid responsiveness in children with idiopathic nephrotic syndrome
Published in European journal of clinical pharmacology (01-12-2019)“…Purpose Idiopathic nephrotic syndrome (INS) is the most frequent form of childhood nephrotic syndrome. Steroids represent the best therapeutic option; however,…”
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Association between BclI polymorphism in the NR3C1 gene and in vitro individual variations in lymphocyte responses to methylprednisolone
Published in British journal of clinical pharmacology (01-04-2012)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In vitro lymphocyte steroid sensitivity has been suggested as a useful tool to predict in vivo response to…”
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Multicentric Case-Control Study on Azathioprine Dose and Pharmacokinetics in Early-onset Pediatric Inflammatory Bowel Disease
Published in Inflammatory bowel diseases (01-04-2017)“…Early-onset inflammatory bowel disease (IBD) is generally aggressive, with a high probability of complications and need of surgery. Despite the introduction of…”
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Deletion of Glutathione-S-Transferase M1 Reduces Azathioprine Metabolite Concentrations in Young Patients With Inflammatory Bowel Disease
Published in Journal of clinical gastroenterology (01-01-2014)“…GOALS:To investigate, in young patients with inflammatory bowel disease (IBD) treated with azathioprine, the association between genetic polymorphisms of…”
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Causes of Treatment Failure in Children With Inflammatory Bowel Disease Treated With Infliximab
Published in Journal of pediatric gastroenterology and nutrition (01-01-2019)“…ABSTRACT Objectives: Anti‐tumor necrosis factor antibodies have led to a revolution in the treatment of inflammatory bowel diseases (IBD); however, a sizable…”
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Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome
Published in Pharmacogenomics (01-09-2015)“…Idiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even…”
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SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome
Published in Pharmacogenomics (01-07-2016)“…of the study was to analyse the impact of SXR rs3842689 polymorphism on the response to corticosteroids in pediatric idiopathic nephrotic syndrome. 66 children…”
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Azathioprine pharmacokinetics in early onset inflammatory bowel disease
Published in Digestive and liver disease (30-09-2014)Get full text
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Association between Bcl I polymorphism in the NR3C1 gene and in vitro individual variations in lymphocyte responses to methylprednisolone
Published in British journal of clinical pharmacology (01-04-2012)“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • In vitro lymphocyte steroid sensitivity has been suggested as a useful tool to predict in vivo response to…”
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Differential action of 3-hydroxyanthranilic acid on viability and activation of stimulated lymphocytes
Published in International immunopharmacology (01-12-2011)“…Lymphocytes proliferation after antigen-driven activation leads to an increase in cell count, which could last some week, until apoptosis mechanisms allow the…”
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Fate of Lymphocytes after Withdrawal of Tofacitinib Treatment: e85463
Published in PloS one (01-01-2014)“…Tofacitinib (Tofa) is an inhibitor of Janus Kinase 3, developed for the treatment of autoimmune diseases and for the prevention of transplant rejection. Due to…”
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