Lack of relationship between glycemic control and bone mineral density in type 2 diabetes mellitus

Lack of relationship between glycemic control and bone mineral density in type 2 diabetes mellitus

We assessed the effect of chronic hyperglycemia on bone mineral density (BMD) and bone remodeling in patients with type 2 diabetes mellitus. We investigated 42 patients with type 2 diabetes under stable control for at least 1 year, 22 of them with good metabolic control (GMC: mean age = 48.8 +/- 1.5...

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Published in:Brazilian journal of medical and biological research Vol. 40; no. 2; pp. 221 - 227
Main Authors: Cutrim, D M S L, Pereira, F A, de Paula, F J A, Foss, M C
Format: Journal Article
Language:English
Published: Brazil Associação Brasileira de Divulgação Científica 01-02-2007
Subjects:
Absorptiometry, Photon
BIOLOGY
Biomarkers - blood
Bone Density - physiology
Bone markers
Bone mineral density
Bone Remodeling - physiology
Case-Control Studies
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - metabolism
Female
Glycemic control
Humans
Hyperglycemia - blood
Hyperglycemia - metabolism
Insulin-like growth factor I
Male
MEDICINE, RESEARCH & EXPERIMENTAL
Middle Aged
Osteoporosis
Glycemic control
Osteoporosis
Bone mineral density
Insulin-like growth factor I
Bone markers
Diabetes mellitus
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Summary:We assessed the effect of chronic hyperglycemia on bone mineral density (BMD) and bone remodeling in patients with type 2 diabetes mellitus. We investigated 42 patients with type 2 diabetes under stable control for at least 1 year, 22 of them with good metabolic control (GMC: mean age = 48.8 +/- 1.5 years, 11 females) and 20 with poor metabolic control (PMC: mean age = 50.2 +/- 1.2 years, 8 females), and 24 normal control individuals (CG: mean age = 46.5 +/- 1.1 years, 14 females). We determined BMD in the femoral neck and at the L2-L4 level (DEXA) and serum levels of glucose, total glycated hemoglobin (HbA1), total and ionic calcium, phosphorus, alkaline phosphatase, follicle-stimulating hormone, intact parathyroid hormone (iPTH), 25-hydroxyvitamin D (25-OH-D), insulin-like growth factor I (IGFI), osteocalcin, procollagen type I C propeptide, as well as urinary levels of deoxypyridinoline and creatinine. HbA1 levels were significantly higher in PMC patients (12.5 +/- 0.6 vs 7.45 +/- 0.2% for GMC and 6.3 +/- 0.9% for CG; P < 0.05). There was no difference in 25-OH-D, iPTH or IGFI levels between the three groups. BMD values at L2-L4 (CG = 1.068 +/- 0.02 vs GMC = 1.170 +/- 0.03 vs PMC = 1.084 +/- 0.02 g/cm(2)) and in the femoral neck (CG = 0.898 +/- 0.03 vs GMC = 0.929 +/- 0.03 vs PMC = 0.914 +/- 0.03 g/cm(2)) were similar for all groups. PMC presented significantly lower osteocalcin levels than the other two groups, whereas no significant difference in urinary deoxypyridine was observed between groups. The present results demonstrate that hyperglycemia is not associated with increased bone resorption in type 2 diabetes mellitus and that BMD is not altered in type 2 diabetes mellitus.
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ISSN:0100-879X
1414-431X
1414-431X
DOI:10.1590/S0100-879X2006005000054