Search Results - "Cutmore, Lauren C"

Optimization of anti-CD19 CAR T cell production for treatment of patients with chronic lymphocytic leukemia by Amatya, Christina, Weissler, Katherine A., Fellowes, Vicki, Lam, Norris, Cutmore, Lauren C., Natrakul, Danielle A., Highfill, Steven L., Kochenderfer, James N.

“…T cells expressing anti-CD19 chimeric antigen receptors (CARs) have activity against chronic lymphocytic leukemia (CLL), but complete response rates range from…”
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Ligand-bound integrin αvβ6 internalisation and trafficking by Meecham, Amelia, Cutmore, Lauren C, Protopapa, Pantelitsa, Rigby, Lauren G, Marshall, John F

“…The integrin αvβ6 is expressed at low levels in most normal healthy tissue but is very often upregulated in a disease context including cancer and fibrosis…”
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Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer by Cutmore, Lauren C, Marshall, John F

“…CAR T cells have revolutionised the treatment of haematological malignancies. Despite this, several obstacles still prohibit their widespread use and efficacy…”
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Syngeneic Mouse Models for Pre-Clinical Evaluation of CAR T Cells by Ahmed, Eman N, Cutmore, Lauren C, Marshall, John F

“…Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of hematological malignancies. Unfortunately, this improvement has yet to be…”
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Integrin-αvβ6 targeted peptide-toxin therapy in a novel αvβ6-expressing immunocompetent model of pancreatic cancer by Brown, Nicholas F., Murray, Elizabeth R., Cutmore, Lauren C., Howard, Philip, Masterson, Luke, Zammarchi, Francesca, Hartley, John A., van Berkel, Patrick H., Marshall, John F.

“…Previously we reported that a novel αvβ6-specific peptide-drug conjugate (SG3299) could eliminate established human pancreatic ductal adenocarcinoma (PDAC)…”
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Adoptive Transfer of T Cells Genetically Engineered to Express T-Cell Receptors Targeting Neoantigens Arising from p53 and Ras Hotspot Mutations in Hematologic Malignancies by Cappell, Kathryn M, Kim, Sanghyun P, Levin, Noam, Lam, Norris, Amatya, Christina, Cutmore, Lauren C, Beyer, Rachel, Rosenberg, Steven A, Kochenderfer, James N

“…The tumor suppressor gene p53 and the oncogenes NRAS and KRAS (shortened to Ras) are frequently mutated in many difficult-to-treat hematologic malignancies…”
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