Search Results - "Cutler, Roy G"

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats by Stranahan, Alexis M., Norman, Eric D., Lee, Kim, Cutler, Roy G., Telljohann, Richard S., Egan, Josephine M., Mattson, Mark P.

“…Overall dietary energy intake, particularly the consumption of simple sugars such as fructose, has been increasing steadily in Western societies, but the…”
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Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons by Egan, Josephine M, Mattson, Mark P, Lee, Kim, Arumugam, Thiruma V, Stranahan, Alexis M, Cutler, Roy G

“…Many organ systems are adversely affected by diabetes, including the brain, which undergoes changes that may increase the risk of cognitive decline. Although…”
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Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice by Stranahan, Alexis M., Lee, Kim, Martin, Bronwen, Maudsley, Stuart, Golden, Erin, Cutler, Roy G., Mattson, Mark P.

“…Diabetes may adversely affect cognitive function, but the underlying mechanisms are unknown. To investigate whether manipulations that enhance neurotrophin…”
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Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease by Halagappa, Veerendra Kumar Madala, Guo, Zhihong, Pearson, Michelle, Matsuoka, Yasuji, Cutler, Roy G, LaFerla, Frank M, Mattson, Mark P

“…Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function associated with the…”
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The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up‐regulation by Liu, Dong, Zhang, Yongqing, Gharavi, Robert, Park, Hee Ra, Lee, Jaewon, Siddiqui, Sana, Telljohann, Richard, Nassar, Matthew R., Cutler, Roy G., Becker, Kevin G., Mattson, Mark P.

“…Mitochondrial metabolism is highly responsive to nutrient availability and ongoing activity in neuronal circuits. The molecular mechanisms by which brain cells…”
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Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions by Argüelles, Sandro, Camandola, Simonetta, Cutler, Roy G., Ayala, Antonio, Mattson, Mark P.

“…Elongation factor-2 (eEF2) catalyzes the movement of the ribosome along the mRNA. A single histidine residue in eEF2 (H715) is modified to form diphthamide. A…”
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Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia by Son, Tae Gen, Camandola, Simonetta, Arumugam, Thiruma V, Cutler, Roy G, Telljohann, Richard S, Mughal, Mohamed R, Moore, Tyson A, Luo, Weiming, Yu, Qian-Sheng, Johnson, Delinda A, Johnson, Jeffrey A, Greig, Nigel H, Mattson, Mark P

“…J. Neurochem. (2010) 112, 1316-1326. Many phytochemicals function as noxious agents that protect plants against insects and other damaging organisms. However,…”
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Involvement of Oxidative Stress-Induced Abnormalities in Ceramide and Cholesterol Metabolism in Brain Aging and Alzheimer's Disease by Cutler, Roy G., Kelly, Jeremiah, Storie, Kristin, Pedersen, Ward A., Tammara, Anita, Hatanpaa, Kimmo, Troncoso, Juan C., Mattson, Mark P., Brady, Roscoe O.

“…Alzheimer's disease (AD) is an age-related disorder characterized by deposition of amyloid β-peptide (Aβ) and degeneration of neurons in brain regions such as…”
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Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment by de Mello-Coelho, Valeria, Cutler, Roy G., Bunbury, Allyson, Tammara, Anita, Mattson, Mark P., Taub, Dennis D.

“…•Basal inflammation, oxidative stress and lipotoxicity occur in the aging thymus.•Lipid peroxidation increases in total thymus and thymocytes with age.•Aging…”
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The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders by Cutler, Roy G, Camandola, Simonetta, Malott, Kelli F, Edelhauser, Maria A, Mattson, Mark P

“…High uric acid (UA levels have been correlated with a reduced risk of many neurodegenerative diseases through mechanisms involving chelating Fenton reaction…”
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Folic Acid Deficiency and Homocysteine Impair DNA Repair in Hippocampal Neurons and Sensitize Them to Amyloid Toxicity in Experimental Models of Alzheimer's Disease by Kruman, Inna I, Kumaravel, T. S, Lohani, Althaf, Pedersen, Ward A, Cutler, Roy G, Kruman, Yuri, Haughey, Norman, Lee, Jaewon, Evans, Michele, Mattson, Mark P

“…Recent epidemiological and clinical data suggest that persons with low folic acid levels and elevated homocysteine levels are at increased risk of Alzheimer's…”
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Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease by Duan, Wenzhen, Ladenheim, Bruce, Cutler, Roy G., Kruman, Inna I., Cadet, Jean Lud, Mattson, Mark P.

“…Although the cause of Parkinson's disease (PD) is unknown, data suggest roles for environmental factors that may sensitize dopaminergic neurons to age‐related…”
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Molecular control of the amount, subcellular location, and activity state of translation elongation factor 2 in neurons experiencing stress by Argüelles, Sandro, Camandola, Simonetta, Hutchison, Emmette R., Cutler, Roy G., Ayala, Antonio, Mattson, Mark P.

“…Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery whereby it controls the movement of the ribosome along…”
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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model by Zhang, Peisu, Kishimoto, Yuki, Grammatikakis, Ioannis, Gottimukkala, Kamalvishnu, Cutler, Roy G., Zhang, Shiliang, Abdelmohsen, Kotb, Bohr, Vilhelm A., Misra Sen, Jyoti, Gorospe, Myriam, Mattson, Mark P.

“…Neuritic plaques, a pathological hallmark in Alzheimer’s disease (AD) brains, comprise extracellular aggregates of amyloid-beta (Aβ) peptide and degenerating…”
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p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism by Duan, Wenzhen, Zhu, Xiaoxiang, Ladenheim, Bruce, Yu, Qian-Sheng, Guo, Zhihong, Oyler, Jon, Cutler, Roy G., Cadet, Jean Lud, Greig, Nigel H., Mattson, Mark P.

“…Drugs currently used for patients with Parkinson's disease provide temporary relief of symptoms but do not halt or slow the underlying neurodegenerative…”
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Folate deficiency inhibits proliferation of adult hippocampal progenitors by Kruman, Inna I, Mouton, Peter R, Emokpae, Roland, Cutler, Roy G, Mattson, Mark P

“…Neurogenesis in the adult hippocampus may play important roles in learning and memory, and in recovery from injury. As recent findings suggest, the perturbance…”
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The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women by Harvie, Michelle, Wright, Claire, Pegington, Mary, McMullan, Debbie, Mitchell, Ellen, Martin, Bronwen, Cutler, Roy G., Evans, Gareth, Whiteside, Sigrid, Maudsley, Stuart, Camandola, Simonetta, Wang, Rui, Carlson, Olga D., Egan, Josephine M., Mattson, Mark P., Howell, Anthony

“…Intermittent energy restriction may result in greater improvements in insulin sensitivity and weight control than daily energy restriction (DER). We tested two…”
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Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans by Cutler, Roy G., Thompson, Kenneth W., Camandola, Simonetta, Mack, Kendra T., Mattson, Mark P.

“…•Long-chain sphingolipids and ceramides accumulate in Caenorhabditis elegans during aging.•Sphingolipid and ceramide levels are reduced in dauer and…”
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Uric acid enhances longevity and endurance and protects the brain against ischemia by Cutler, Roy G., Camandola, Simonetta, Feldman, Neil H., Yoon, Jeong Seon, Haran, James B., Arguelles, Sandro, Mattson, Mark P.

“…Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional…”
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Role of dietary iron restriction in a mouse model of Parkinson's disease by Levenson, Cathy W., Cutler, Roy G., Ladenheim, Bruce, Cadet, Jean L., Hare, Joan, Mattson, Mark P.

“…There is a growing body of evidence suggesting that iron chelation may be a useful therapy in the treatment of Parkinson's Disease (PD). Experiments were…”
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