Search Results - "Cutler, Geoffrey J."

Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines by Alberti, Michael J., Auten, Elizabeth P., Lackey, Karen E., McDonald, Octerloney B., Wood, Edgar R., Preugschat, Frank, Cutler, Geoffrey J., Kane-Carson, Laurie, Liu, Wei, Jung, David K.

“…The discovery, synthesis, and in vitro kinase profile of several pyrido[1′,2′:1,5]pyrazolo[3,4- d]pyrimidines as potent kinase inhibitors are discussed. The…”
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Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β) by Christopher, John A, Bamborough, Paul, Alder, Catherine, Campbell, Amanda, Cutler, Geoffrey J, Down, Kenneth, Hamadi, Ahmed M, Jolly, Adrian M, Kerns, Jeffrey K, Lucas, Fiona S, Mellor, Geoffrey W, Miller, David D, Morse, Mary A, Pancholi, Kiritkant D, Rumsey, William, Solanke, Yemisi E, Williamson, Rick

“…The identification and progression of a potent and selective series of isoquinoline inhibitors of IκB kinase-β (IKK-β) are described. Hit-generation chemistry…”
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The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β kinases by Christopher, John A., Avitabile, Barbara G., Bamborough, Paul, Champigny, Aurelie C., Cutler, Geoffrey J., Dyos, Susan L., Grace, Ken G., Kerns, Jeffrey K., Kitson, Jeremy D., Mellor, Geoffrey W., Morey, James V., Morse, Mary A., O’Malley, Carolyn F., Patel, Champa B., Probst, Nicholas, Rumsey, William, Smith, Clive A., Wilson, Michael J.

“…A potent and selective series of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β is described. The most potent compounds are 8h, 8r and 8v, with…”
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3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β by Miller, David D., Bamborough, Paul, Christopher, John A., Baldwin, Ian R., Champigny, Aurelie C., Cutler, Geoffrey J., Kerns, Jeffrey K., Longstaff, Timothy, Mellor, Geoffrey W., Morey, James V., Morse, Mary A., Nie, Hong, Rumsey, William L., Taggart, John J.

“…The discovery and hit-to-lead exploration of a novel series of selective IKK-β kinase inhibitors is described. The initial lead fragment 3 was identified by…”
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4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors by Liddle, John, Bamborough, Paul, Barker, Michael D., Campos, Sebastien, Cousins, Rick P.C., Cutler, Geoffrey J., Hobbs, Heather, Holmes, Duncan S., Ioannou, Chris, Mellor, Geoff W., Morse, Mary A., Payne, Jeremy J., Pritchard, John M., Smith, Kathryn J., Tape, Daniel T., Whitworth, Caroline, Williamson, Richard A.

“…The synthesis and SAR of 4-aryl-7-azaindoles as ATP-competitive IKK2 inhibitors is described. Modification around the hinge binding region of the 7-azaindole…”
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5-(1 H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase by Bamborough, Paul, Christopher, John A., Cutler, Geoffrey J., Dickson, Marion C., Mellor, Geoffrey W., Morey, James V., Patel, Champa B., Shewchuk, Lisa M.

“…The identification and hit-to-lead exploration of a novel, potent, and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-…”
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3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IIK-β by MILLER, David D, BAMBOROUGH, Paul, MORSE, Mary A, HONG NIE, RUMSEY, William L, TAGGART, John J, CHRISTOPHER, John A, BALDWIN, Ian R, CHAMPIGNY, Aurelie C, CUTLER, Geoffrey J, KERNS, Jeffrey K, LONGSTAFF, Timothy, MELLOR, Geoffrey W, MOREY, James V

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Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IKB Kinase-β (IKK-β) by CHRISTOPHER, John A, BAMBOROUGH, Paul, MELLOR, Geoffrey W, MILLER, David D, MORSE, Mary A, PANCHOLI, Kiritkant D, RUMSEY, William, SOLANKE, Yemisi E, WILLIAMSON, Rick, ALDER, Catherine, CAMPBELL, Amanda, CUTLER, Geoffrey J, DOWN, Kenneth, HAMADI, Ahmed M, JOLLY, Adrian M, KERNS, Jeffrey K, LUCAS, Fiona S

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Discovery and in vitro evaluation of potent kinase inhibitors : Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines: G-protein-coupled receptors in drug discovery by ALBERTI, Michael J, AUTEN, Elizabeth P, LACKEY, Karen E, MCDONALD, Octerloney B, WOOD, Edgar R, PREUGSCHAT, Frank, CUTLER, Geoffrey J, KANE-CARSON, Laurie, WEI LIU, JUNG, David K

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Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) by Christopher, John A, Bamborough, Paul, Alder, Catherine, Campbell, Amanda, Cutler, Geoffrey J, Down, Kenneth, Hamadi, Ahmed M, Jolly, Adrian M, Kerns, Jeffrey K, Lucas, Fiona S, Mellor, Geoffrey W, Miller, David D, Morse, Mary A, Pancholi, Kiritkant D, Rumsey, William, Solanke, Yemisi E, Williamson, Rick

“…The identification and progression of a potent and selective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described. Hit-generation…”
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