Search Results - "Cuthbertson, James D."

The direct arylation of allylic sp3 C–H bonds via organic and photoredox catalysis by Cuthbertson, James D., MacMillan, David W. C.

“…Photoredox and organic catalysis are combined to achieve broadly effective direct arylation of allylic carbon–hydrogen bonds under mild conditions; this…”
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Palladium-Catalyzed Enantioselective C–H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands by Smalley, Adam P, Cuthbertson, James D, Gaunt, Matthew J

“…The design of an enantioselective Pd­(II)-catalyzed C–H amination reaction is described. The use of a chiral BINOL phosphoric acid ligand enables the…”
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Redox-neutral organocatalytic Mitsunobu reactions by Beddoe, Rhydian H, Andrews, Keith G, Magné, Valentin, Cuthbertson, James D, Saska, Jan, Shannon-Little, Andrew L, Shanahan, Stephen E, Sneddon, Helen F, Denton, Ross M

“…Nucleophilic substitution reactions of alcohols are among the most fundamental and strategically important transformations in organic chemistry. For over half…”
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Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds by James, Michael J., Cuthbertson, James D., O'Brien, Peter, Taylor, Richard J. K., Unsworth, William P.

“…A high‐yielding silver(I)‐ or copper(II)‐catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain…”
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A Telescoped Route to 2,6-Disubstituted 2,3,4,5-Tetrahydropyridines and 2,6-syn-Disubstituted Piperidines: Total Synthesis of (−)-Grandisine G by Cuthbertson, James D., Taylor, Richard J. K.

“…A grand route to grandisines: A method for the conversion of 6‐acyl cyclohexenones into 2,6‐disubstituted 2,3,4,5‐tetrahydropyridines and, after…”
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The direct arylation of allylic sp(3) C-H bonds via organic and photoredox catalysis by Cuthbertson, James D, MacMillan, David W C

“…The direct functionalization of unactivated sp(3) C-H bonds is still one of the most challenging problems facing synthetic organic chemists. The appeal of such…”
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Asymmetric Decarboxylative Allylation of Oxindoles by Franckevičius, Vilius, Cuthbertson, James D, Pickworth, Mark, Pugh, David S, Taylor, Richard J. K

“…An asymmetric decarboxylative palladium-catalyzed allylation of alkyl- and aryl-substituted oxindoles has been developed, enabling the installation of an…”
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Native functionality in triple catalytic cross-coupling: sp³ C–H bonds as latent nucleophiles by Shaw, Megan H., Shurtleff, Valerie W., Terrett, Jack A., Cuthbertson, James D., MacMillan, David W. C.

“…The use of sp³ C–H bonds—which are ubiquitous in organic molecules—as latent nucleophile equivalents for transition metal–catalyzed cross-coupling reactions…”
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Switching on elusive organometallic mechanisms with photoredox catalysis by Terrett, Jack A., Cuthbertson, James D., Shurtleff, Valerie W., MacMillan, David W. C.

“…Despite advances in carbon–carbon fragment couplings, the ability to forge carbon–oxygen bonds in a general fashion via nickel catalysis has been largely…”
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Chemoselective Late-Stage Functionalization of Peptides via Photocatalytic C2-Alkylation of Tryptophan by Lee, Joanna C., Cuthbertson, James D., Mitchell, Nicholas J.

“…Across eukaryotic proteomes, tryptophan is the least abundant of the 20 canonical amino acids, which makes it an ideal chemical handle for the late-stage…”
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A Redox-Relay Heck Approach to Substituted Tetrahydrofurans by Byrne, Tom J. M., Mylrea, Megan E., Cuthbertson, James D.

“…An operationally simple and efficient strategy for the synthesis of substituted tetrahydrofurans from readily available cis-butene-1,4-diol is described. A…”
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A Domino Radical Amidation/Semipinacol Approach to All‐Carbon Quaternary Centers Bearing an Aminomethyl Group by Dhak, Mandeep S., Arunprasath, Dhanarajan, Argent, Stephen P., Cuthbertson, James D.

“…A photoredox‐mediated radical amidation ring‐expansion sequence that enables the generation of all‐carbon quaternary centers bearing a protected aminomethyl…”
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Total Synthesis of Spirobacillene A by Unsworth, William P, Cuthbertson, James D, Taylor, Richard J. K

“…The first total synthesis of spirobacillene A, an indole alkaloid isolated from Lysinibacillus fusiformis, is reported. A Lewis acid mediated spirocyclization…”
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Alkyne-Acetal Cyclisation Reactions Mediated by Formic Acid; 3-Acylated-2,5-dihydrofurans and Related Oxygen and Nitrogen Heterocycles by J. K. Taylor, Richard, D. Cuthbertson, James, A. Godfrey, Andrew, P. Unsworth, William

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Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds by James, Michael J., Cuthbertson, James D., O'Brien, Peter, Taylor, Richard J. K., Unsworth, William P.

“…A high‐yielding silver(I)‐ or copper(II)‐catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain…”
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Correction to “Palladium-Catalyzed Enantioselective C–H Activation of Aliphatic Amines Using Chiral Anionic BINOL-Phosphoric Acid Ligands” by Smalley, Adam P, Cuthbertson, James D, Gaunt, Matthew J

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The Preparation of (−)-Grandisine B from (+)-Grandisine D; A Biomimetic Total Synthesis or Formation of an Isolation Artefact? by Cuthbertson, James D, Godfrey, Andrew A, Taylor, Richard J. K

“…An efficient new alkyne-acetal cyclization procedure has been developed to prepare enantiopure indolizidine building blocks from l-proline and then applied to…”
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Synthesis of isoquinuclidinones via a tandem amination/imination sequence: application to the synthesis of (−)-mearsine by Cuthbertson, James D., Godfrey, Andrew A., Taylor, Richard J.K.

“…The facile synthesis of a range of novel isoquinuclidinones from 6-acyl-cyclohex-2-enones is described, employing aqueous ammonia in a one-pot procedure…”
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A Telescoped Route to 2,6-Disubstituted 2,3,4,5-Tetrahydropyridines and 2,6-syn-Disubstituted Piperidines: Total Synthesis of (−)-Grandisine G by Cuthbertson, James D., Taylor, Richard J. K.

“…„Grand“iose Route: Ein Verfahren zur Überführung von 6‐Acylcyclohexenonen in 2,6‐disubstituierte 2,3,4,5‐Tetrahydropyridine und, nach diastereoselektiver…”
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The direct arylation of allylic [sp.sup.3] C-H bonds via organic and photoredox catalysis by Cuthbertson, James D, MacMillan, David W.C

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