Search Results - "Cuthbert, A. P."

SURF1 , encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome by Shoubridge, Eric A, Zhu, Zhiqing, Yao, Jianbo, Johns, Timothy, Fu, Katherine, Bie, Isabelle De, Macmillan, Carol, Cuthbert, Andrew P, Newbold, Robert F, Wang, Jia-chi, Chevrette, Mario, Brown, Garry K, Brown, Ruth M

“…Leigh Syndrome (LS) is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly…”
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Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast Cancer cells by CUTHBERT, A. P, BOND, J, TROTT, D. A, GILL, S, BRONI, J, MARRIOTT, A, KHOUDOLI, G, PARKINSON, E. K, COOPER, C. S, NEWBOLD, R. F

“…Activation of the enzyme telomerase, which has been associated with cellular immortality, may constitute a key step in the development of human cancer…”
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A telomere-independent senescence mechanism is the sole barrier to Syrian hamster cell immortalization by RUSSO, I, SILVER, A. R. J, CUTHBERT, A. P, GRIFFIN, D. K, TROTT, D. A, NEWBOLD, R. F

“…Reactivation of telomerase and stabilization of telomeres occur simultaneously during human cell immortalization in vitro and the vast majority of human…”
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A Novel Syndrome Affecting Multiple Mitochondrial Functions, Located by Microcell-Mediated Transfer to Chromosome 2p14-2p13 by Seyda, Agnieszka, Newbold, Robert F., Hudson, Thomas J., Verner, Andrei, MacKay, Neviana, Winter, Susan, Feigenbaum, Annette, Malaney, Suzann, Gonzalez-Halphen, Diego, Cuthbert, Andrew P., Robinson, Brian H.

“…We have studied cultured skin fibroblasts from three siblings and one unrelated individual, all of whom had fatal mitochondrial disease manifesting soon after…”
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SNP Subset Selection for Genetic Association Studies by Byng, M. C., Whittaker, J. C., Cuthbert, A. P., Mathew, C. G., Lewis, C. M.

“…Summary Association studies for disease susceptibility genes rely on the high density of SNPs within candidate genes. However, the linkage disequilibrium…”
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Telomerase Suppression by Chromosome 6 in a Human Papillomavirus Type 16-Immortalized Keratinocyte Cell Line and in a Cervical Cancer Cell Line by Steenbergen, Renske D. M., Kramer, Debbie, Meijer, Chris J. L. M., Walboomers, Jan M. M., Trott, Deborah A., Cuthbert, Andrew P., Newbold, Robert F., Overkamp, Wilhelmina J. I., Zdzienicka, Malgorzata Z., Snijders, Peter J. F.

“…Background: High-risk human papillomavirus (HPV) types play a major role in the development of cervical cancer in vivo and can induce immortalization of…”
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Human squamous cell carcinomas lose a mortality gene from chromosome 6q14.3 to q15 by FITZSIMMONS, S. A, IRELAND, H, BARR, N. I, CUTHBERT, A. P, GOING, J. J, NEWBOLD, R. F, PARKINSON, E. K

“…Normal human keratinocytes possess a finite replicative lifespan. Most advanced squamous cell carcinomas (SCCs), however, are immortal, a phenotype that is…”
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Genetic association between EPHX1 and Crohn’s disease: population stratification, genotyping error, or random chance? by Cuthbert, A P, Fisher, S A, Lewis, C M, Mathew, C G, Sanderson, J, Forbes, A

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Genetic Variation at the Chromosome 16 Chemokine Gene Cluster: Development of a Strategy for Association Studies in Complex Disease by Fisher, S. A., Moody, A., Mirza, M. M., Cuthbert, A. P., Hampe, J., Macpherson, A., Sanderson, J., Forbes, A., Mansfield, J., Schreiber, S., Lewis, C. M., Mathew, C. G.

“…Summary The chemokine gene cluster [CCL22, CX3CL1, CCL17] (previously known as [SCYA22, SCYD1, SCYA17]) is a candidate locus for one of the susceptibility…”
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Construction and characterization of a highly stable human: rodent monochromosomal hybrid panel for genetic complementation and genome mapping studies by Cuthbert, A P, Trott, D A, Ekong, R M, Jezzard, S, England, N L, Themis, M, Todd, C M, Newbold, R F

“…Human:rodent somatic cell hybrids carrying a single, intact, selectable human chromosome are valuable both for functional somatic cell genetic analysis and…”
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Genetic and functional analyses exclude mortality factor 4 (MORF4) as a keratinocyte senescence gene by BRYCE, S. D, FORSYTH, N. R, FITZSIMMONS, S. A, CLARK, L. J, BERTRAM, M. J, CUTHBERT, A. P, NEWBOLD, R. F, PEREIRA-SMITH, O. M, PARKINSON, E. K

“…Approximately 50% of immortal human keratinocyte lines show loss of heterozygosity of chromosome region 4q33-q34, and the reintroduction of chromosome 4 into…”
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Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens by Trott, D A, Cuthbert, A P, Overell, R W, Russo, I, Newbold, R F

“…Immortalization is a prerequisite for the clonal evolution and malignant transformation of normal mammalian cells in culture. In order to gain a mechanistic…”
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Human chromosome 16 suppresses metastasis but not tumorigenesis in rat prostatic tumor cells by MASHIMO, T, WATABE, M, CUTHBERT, A. P, NEWBOLD, R. F, RINKER-SCHAEFFER, C. W, HELFER, E, WATABE, K

“…Genomic aberrations at the chromosome 16q arm are one of the most consistent abnormalities observed by loss of heterozygosity and comparative genomic…”
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Functional evidence of novel tumor suppressor genes for cutaneous malignant melanoma by PARRIS, C. N, HARRIS, J. D, GRIFFIN, D. K, CUTHBERT, A. P, SILVER, A. J. R, NEWBOLD, R. F

“…Losses of heterozygosity involving chromosomes 9 and 10 are frequent events in the development and progression of cutaneous malignant melanoma. To investigate…”
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Identification of human tumour suppressor genes by monochromosome transfer : rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A) by ENGLAND, N. L, CUTHBERT, A. P, TROTT, D. A, JEZZARD, S, NOBORI, T, CARSON, D. A, NEWBOLD, R. F

“…Microcell transfer of intact normal human chromosomes into immortal mouse and hamster fibroblast cell lines has revealed growth suppressive activity associated…”
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Genetic Evidence for Interaction of the 5q31 Cytokine Locus and the CARD15 Gene in Crohn Disease by Mirza, Muddassar M., Fisher, Sheila A., King, Kathy, Cuthbert, Andrew P., Hampe, Jochen, Sanderson, Jeremy, Mansfield, John, Donaldson, Peter, Andrew Macpherson, J.S., Forbes, Alastair, Schreiber, Stefan, Cathryn Lewis, M., Christopher Mathew, G.

“…A common haplotype spanning 250 kb in the cytokine gene cluster on chromosome 5q31 has recently been reported to be strongly associated with Crohn disease (CD)…”
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Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli by Sullivan, Gareth J., Bridger, Joanna M., Cuthbert, Andrew P., Newbold, Robert F., Bickmore, Wendy A., McStay, Brian

“…Human ribosomal gene repeats are distributed among five nucleolar organizer regions (NORs) on the p arms of acrocentric chromosomes. On exit from mitosis,…”
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Regulation of human telomerase activity: Repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity by DUCREST, Anne-Lyse, AMACKER, Mario, MATHIEU, Yves D, CUTHBERT, Andrew P, TROTT, Deborah A, NEWBOLD, Robert F, NABHOLZ, Markus, LINGNER, Joachim

“…Telomerase is required for the complete replication of chromosomal ends. In tumors, the human telomerase reverse transcriptase subunit (hTERT) is up-regulated,…”
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Cell immortalization as a key, rate-limiting event in malignant transformation: approaches toward a molecular genetic analysis by Newbold, R F, Cuthbert, A P, Themis, M, Trott, D A, Blair, A L, Li, W

“…Recent advances using somatic cell genetic approaches have provided a convincing body of evidence that the senescence of mammalian cells in culture is…”
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A chromosome 3-encoded repressor of the human telomerase reverse transcriptase (hTERT) gene controls the state of hTERT chromatin by SZUTORISZ, Henrietta, LINGNER, Joachim, CUTHBERT, Andrew P, TROTT, Deborah A, NEWBOLD, Robert F, NABHOLZ, Markus

“…Telomerase is crucial for human carcinogenesis. The limiting component of telomerase activity is telomerase reverse transcriptase (hTERT), undetectable in…”
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