Search Results - "Custer, Mary C."

Efficient Transfer of a Tumor Antigen-Reactive TCR to Human Peripheral Blood Lymphocytes Confers Anti-Tumor Reactivity by Clay, Timothy M, Custer, Mary C, Sachs, Jessica, Hwu, Patrick, Rosenberg, Steven A, Nishimura, Michael I

“…The tumor-associated-Ag MART-1 is expressed by most human melanomas. The genes encoding an alphabeta TCR from a MART-1-specific, HLA-A2-restricted, human T…”
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Characterization of an antibody that can detect the Kai1/CD82 murine metastasis suppressor by Custer, Mary C., Risinger, John I., Hoover, Shelley, Simpson, R. Mark, Patterson, Tricia, Barrett, J. Carl

“…BACKGROUND Kai1, also known as CD82, is a member of the tetraspanin family (TM4SF). The human homolog, KAI1, is an activation antigen of T‐cells and is a…”
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Changes in the Fine Specificity of gp100(209-217)-Reactive T Cells in Patients Following Vaccination with a Peptide Modified at an HLA-A2.1 Anchor Residue by Clay, Timothy M, Custer, Mary C, McKee, Mark D, Parkhurst, Maria, Robbins, Paul F, Kerstann, Keith, Wunderlich, John, Rosenberg, Steven A, Nishimura, Michael I

“…In a recent clinical trial, HLA-A2+ melanoma patients were vaccinated with a peptide derived from the melanoma Ag gp100, which had been modified at the second…”
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MHC class I-restricted recognition of a melanoma antigen by a human CD4+ tumor infiltrating lymphocyte by NISHIMURA, M. I, AVICHEZER, D, CUSTER, M. C, LEE, C. S, CHEN, C, PARKHURST, M. R, DIAMOND, R. A, ROBBINS, P. F, SCHWARTZENTRUBER, D. J, ROSENBERG, S. A

“…It is generally considered that MHC class I-restricted antigens are recognized by CD8+ T cells, whereas MHC class II-restricted antigens are recognized by CD4+…”
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Potential Use of T Cell Receptor Genes to Modify Hematopoietic Stem Cells for the Gene Therapy of Cancer by Clay, Timothy M, Custer, Mary C, Spiess, Paul J, Nishimura, Michael I

“…The purpose of this review is to illustrate some of the technical and biological hurdles that need to be addressed when developing new gene therapy based…”
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Characterization of an antibodythat can detect the kail/CD82 murine metastasis suppressor by CUSTER, Mary C, RISINGER, John I, HOOVER, Shelley, SIMPSON, R. Mark, PATTERSON, Tricia, BARRETT, J. Carl

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Intraperitoneal administration of interleukin-2 in patients with cancer by Lotze, M T, Custer, M C, Rosenberg, S A

“…We have administered 11 to 64 doses of recombinant interleukin-2 (IL-2) ranging from 10,000 to 300,000 U/kg, given three times daily as a bolus infusion…”
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IL-7 induces human lymphokine-activated killer cell activity and is regulated by IL-4 by Stotter, H, Custer, MC, Bolton, ES, Guedez, L, Lotze, MT

“…Induction of lymphokine-activated killer (LAK) activity by IL-2 has been described and characterized as broadly cytolytic activity against both fresh and…”
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In vivo administration of purified human interleukin-2 to patients with cancer: development of interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors following interleukin-2 administration by LOTZE, M. T, CUSTER, M. C, SHARROW, S. O, RUBIN, L. A, NELSON, D. L, ROSENBERG, S. A

“…Recent studies have demonstrated efficacy of immunotherapies including interleukin-2 (IL-2) in the treatment of malignancies in rodents and humans. High levels…”
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T cell-receptor V gene use by CD4+ melanoma-reactive clonal and oligoclonal T-cell lines by Nishimura, M I, Custer, M C, Schwarz, S L, Parker, L L, Mixon, A, Clay, T M, Yannelli, J R, Rosenberg, S A

“…Tumor-reactive CD4+ T cells can be isolated and expanded from the peripheral blood and tumor lesions of patients with melanoma. In contrast to CD8+ T cells,…”
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Retroviral transduction of interferon-γ cDNA into a nonimmunogenic murinefibrosarcoma : generation of T cells in draining lymph nodes capable of treating established parental metastatic tumor by SHILONI, E, KARP, S. E, CUSTER, M. C, SHILYANSKY, J, RESTIFO, N. P, ROSENBERG, S. A, MULE, J. J

“…Gene modification of tumor cells with the cDNA for interferon γ (IFNγ) has been shown to increase the immunogenicity of some tumor cells. In order to explore…”
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Identification of a T-cell receptor from a therapeutic murine T-cell clone by Shilyansky, J, Yang, J C, Custer, M C, Spiess, P, Mixon, A, Cole, D J, Mulé, J J, Rosenberg, S A, Nishimura, M I

“…Tumor-infiltrating lymphocytes (TIL) have been successfully used for the treatment of metastatic malignancies in clinical trials and in experimental animal…”
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Retroviral transduction of interferon-? cDNA into a nonimmunogenic murinefibrosarcoma: generation of T cells in draining lymph nodes capable of treating established parental metastatic tumor by Shiloni, Eitan, Karp, Stephen E., Custer, Mary C., Shilyansky, Joel, Restifo, Nicholas P., Rosenberg, Steven A., Mul, James J.

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A biologic assay for IL-4. Rapid fluorescence assay for IL-4 detection in supernatants and serum by Custer, M C, Lotze, M T

“…Interleukin-4 (IL-4) is a lymphokine produced by activated T helper cells with effects on T cells, B cells, monocytes and mast cells. The conventional…”
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Mechanisms of immunologic antitumor therapy: lessons from the laboratory and clinical applications by Lotze, M T, Custer, M C, Bolton, E S, Wiebke, E A, Kawakami, Y, Rosenberg, S A

“…The use of interleukin 2-based immunotherapies for cancer has been associated with significant responses in tumor models in both mouse and humans. Further…”
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Specific binding and lysis of human melanoma by IL-2-activated cells coated with anti-T3 or anti-Fc receptor cross-linked to antimelanoma antibody: a possible approach to the immunotherapy of human tumors by Lotze, M T, Roberts, K, Custer, M C, Segal, D A, Rosenberg, S A

“…Monoclonal antibodies (MoAb) to human melanoma have demonstrated a limited ability to cause tumor regression in humans when used alone or when coupled to…”
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Cytokines alter target cell susceptibility to lysis: I. Evaluation of non-major histocompatibility complex-restricted effectors reveals differential effects on natural and lymphokine-activated killing by Wiebke, E A, Custer, M C, Rosenberg, S A, Lotze, M T

“…Interferon-gamma (IFN) and tumor necrosis factor-alpha (TNF) were examined for their ability to enhance major histocompatibility complex (MHC) expression on a…”
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