Search Results - "Cussans, N"

Pharmacokinetics and metabolism of darifenacin in the mouse, rat, dog and man by BEAUMONT, K. C., CUSSANS, N. J., NICHOLS, D. J., SMITH, D. A.

“…1. Followingintravenousadministrationto animals at 2 5 mg kg, darifenacinexhibited terminal plasma half-lifes < 2 h due to high plasma clearance (with respect…”
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Formation and pharmacokinetics of the active drug candoxatrilat in mouse, rat, rabbit, dog and man following administration of the prodrug candoxatril by KAYE, B., BREARLEY, C. J., CUSSANS, N. J., HERRON, M., HUMPHREY, M. J., MOLLATT, A. R.

“…1. Candoxatrilat, an active neutral endopeptidase inhibitor, was released rapidly from the inactive prodrug candoxatril in vivo in mouse, rat, rabbit, dog and…”
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The sensitive determination of abanoquil in blood by high-performance liquid chromatography/atmospheric pressure ionization mass spectrometry by Kaye, B, Clark, M W, Cussans, N J, Macrae, P V, Stopher, D A

“…A method is described for the determination of abanoquil in human blood. The method is based on high-performance liquid chromatography (HPLC)/atmospheric…”
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The metabolism and kinetics of doxazosin in man, mouse, rat and dog by Kaye, B, Cussans, NJ, Faulkner, JK, Stopher, DA, Reid, JL

“…The metabolic fate of doxazosin was investigated in man, mouse, rat and dog using 14C‐labelled compound. Bioavailability and pharmacokinetic studies were also…”
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The atriopeptidase inhibitor UK 69,578 increases atrial natriuretic factor and causes a natriuresis in normal humans by Jardine, A G, Connell, J M, Northridge, D, Dilly, S G, Cussans, N J, Davidson, G, Doyle, J, Leckie, B L, Lever, A F

“…The endopeptidase EC 3.4.24.11 (atriopeptidase) degrades atrial natriuretic factor (ANF). Intravenous administration of UK 69,578 (0.025 to 10.0 mg/kg), a new…”
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Bioanalytical data in decision making: discovery and development by Smith, D A, Beaumont, K, Cussans, N J, Humphrey, M J, Jezequel, S G, Rance, D J, Stopher, D A, Walker, D K

“…1. Bioanalysis is traditionally associated with the development phase of drugs; its use in discovery programmes is often ignored but can have a major impact…”
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Inhibition of Endopeptidase EC 24.11 in Humans Renal and Endocrine Effects by Richards, Mark, Espiner, Eric, Frampton, Chris, Ikram, Hamid, Yandle, Tim, Sopwith, Mark, Cussans, Nigel

“…The effects of an orally active inhibitor (UK 79300) of the neutral metalloendopeptidase EC 3.4.24.11 were investigated in six healthy male volunteers…”
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A validation study comparing accelerator MS and liquid scintillation counting for analysis of super(14)C-labelled drugs in plasma, urine and faecal extracts by Garner, R C, Barker, J, Flavell, C, Garner, J V, Whattam, M, Yong, G C, Cussans, N, Jezequel, S, Leong, D

“…A comparison has been made between accelerator mass spectrometry (AMS) analysis and liquid scintillation counting (LSC) of plasma, urine and faecal samples…”
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A validation study comparing accelerator MS and liquid scintillation counting for analysis of 14C-labelled drugs in plasma, urine and faecal extracts by Garner, R.C, Barker, J, Flavell, C, Garner, J.V, Whattam, M, Young, G.C, Cussans, N, Jezequel, S, Leong, D

“…A comparison has been made between accelerator mass spectrometry (AMS) analysis and liquid scintillation counting (LSC) of plasma, urine and faecal samples…”
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