High Levels of Tumor Necrosis Factor-α and Interleukin-6 in the Ascitic Fluid of Cirrhotic Patients with Spontaneous Bacterial Peritonitis

High Levels of Tumor Necrosis Factor-α and Interleukin-6 in the Ascitic Fluid of Cirrhotic Patients with Spontaneous Bacterial Peritonitis

We prospectively measured the concentrations of immunoreactive tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) in the serum and ascitic fluid of 14 alcoholic cirrhotic patients with spontaneous bacterial peritonitis (SBP) and 16 alcoholic cirrhotic patients with steri...

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Bibliographic Details
Published in:Clinical infectious diseases Vol. 17; no. 2; pp. 218 - 223
Main Authors: Zeni, Fabrice, Tardy, Bernard, Vindimian, Monique, Comtet, Claude, Page, Yves, Cusey, Isabelle, Bertrand, Jean-Claude
Format: Journal Article
Language:English
Published: Chicago, IL The University of Chicago Press 01-08-1993
University of Chicago Press
Subjects:
Antibiotics
Ascites
Ascitic Fluid
Ascitic Fluid - immunology
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacterial Infections - diagnosis
Bacterial Infections - etiology
Bacterial Infections - immunology
Biological and medical sciences
Case-Control Studies
Clinical Infectious Disease Articles
Cytokines
Female
Human bacterial diseases
Humans
Infections
Infectious diseases
Interleukin-1 - analysis
Interleukin-6 - analysis
Liver Cirrhosis, Alcoholic - complications
Liver Cirrhosis, Alcoholic - immunology
Male
Medical sciences
Middle Aged
Necrosis
Peritonitis
Peritonitis - diagnosis
Peritonitis - etiology
Peritonitis - immunology
Prospective Studies
Recurrence
Septic shock
Tumor Necrosis Factor-alpha - analysis
Tumor necrosis factors
Tumors
Human
Biochemical analysis
Spontaneous
Cytokine
Hepatic disease
Infection
Interleukin 6
Cirrhosis
Ascitic fluid
Abdominal disease
Interleukin 1
Bacteriosis
Digestive diseases
Serum
Ascites
Tumor necrosis factor α
Peritonitis
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Summary:We prospectively measured the concentrations of immunoreactive tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) in the serum and ascitic fluid of 14 alcoholic cirrhotic patients with spontaneous bacterial peritonitis (SBP) and 16 alcoholic cirrhotic patients with sterile ascitic fluid. TNF-α levels in ascitic fluid were significantly higher for the patients with SBP: 399.57 ± 129.23 pg/mL vs. 35.76 ± 5.57 pg/mL (P < .001). IL-6 levels in ascitic fluid were also significantly higher for the patients with SBP: 170,713 ± 57,109 ng/mL vs. 5,414 ± 973 ng/mL (P < .001). By contrast, serum levels of TNF-α and IL-6 were just slightly more elevated than normal values. The concentration of IL-1 in the ascitic fluid of all patients was elevated, but there was no difference between patients with SBP or sterile ascites in this respect. In the patients with SBP, levels of TNF-α and IL-6 in ascitic fluid decreased during the first 48 hours of antibiotic treatment. Our results suggest that measurements of TNF-α and IL-6 in ascitic fluid may become useful markers both for the diagnosis of SBP and for monitoring the treatment of cirrhotic patients.
Bibliography:Reprints or correspondence: Dr. F. Zeni, Intensive Care Unit, Hôpital de Bellevue, CHRU 42023-St. Etienne Cedex, France.
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ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/17.2.218