A Novel Human Prostate-Specific, Androgen-Regulated Homeobox Gene (NKX3.1) That Maps to 8p21, a Region Frequently Deleted in Prostate Cancer

We have isolated a prostate-specific gene (NKX3.1) in humans that is homologous to theDrosophilaNK homeobox gene family. Northern blot analyses indicate that this gene is expressed at high levels in adult prostate and at a much lower level in testis, but is expressed little or not at all in several...

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Published in:	Genomics (San Diego, Calif.) Vol. 43; no. 1; pp. 69 - 77
Main Authors:	He, Wei Wu, Sciavolino, Peter J., Wing, John, Augustus, Meena, Hudson, Peter, Meissner, P.Scott, Curtis, R.Thomas, Shell, Brenda K., Bostwick, David G., Tindall, Donald J., Gelmann, Edward P., Abate-Shen, Cory, Carter, Kenneth C.
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01-07-1997 Elsevier
Subjects:	Adult Amino Acid Sequence Androgens - metabolism Androgens - pharmacology Animals Base Sequence Biological and medical sciences Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome Deletion Chromosome Mapping Chromosomes, Human, Pair 8 - genetics Cloning, Molecular DNA - genetics Drosophila - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Genes, Homeobox Genes, Insect Homeodomain Proteins - genetics Humans In Situ Hybridization, Fluorescence Male Mice Molecular and cellular biology Molecular Sequence Data Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Prostate - growth & development Prostate - metabolism Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Tissue Distribution Transcription Factors - genetics Tumor Cells, Cultured Genetic mapping Human Prostate disease Androgen Homeotic gene Tumor progression Hormonal regulation Tumor Gene expression Male genital diseases Chromosome C8 Prostate
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Summary:	We have isolated a prostate-specific gene (NKX3.1) in humans that is homologous to theDrosophilaNK homeobox gene family. Northern blot analyses indicate that this gene is expressed at high levels in adult prostate and at a much lower level in testis, but is expressed little or not at all in several other tissues. In an androgen-dependent prostate carcinoma line, LNCaP,NKX3.1mRNA is expressed at a basal level that was increased markedly upon androgen stimulation; theNKX3.1mRNA was undetectable in several other human tumor cell lines including two androgen-independent prostate carcinoma lines. TheNKX3.1gene maps to chromosome band 8p21, a region frequently reported to undergo a loss of heterozygosity associated with tissue dedifferentiation and loss of androgen responsiveness during the progression of prostate cancer. Based on these data we propose thatNKX3.1is a candidate gene for playing a role in the opposing processes of androgen-driven differentiation of prostatic tissue and loss of that differentiation during the progression of prostate cancer.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0888-7543 1089-8646
DOI:	10.1006/geno.1997.4715