Search Results - "Curtis, Nicola J"

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity by Curtis, Nicola J, Mooney, Lorraine, Hopcroft, Lorna, Michopoulos, Filippos, Whalley, Nichola, Zhong, Haihong, Murray, Clare, Logie, Armelle, Revill, Mitchell, Byth, Kate F, Benjamin, Amanda D, Firth, Mike A, Green, Stephen, Smith, Paul D, Critchlow, Susan E

“…Tumors frequently display a glycolytic phenotype with increased flux through glycolysis and concomitant synthesis of lactate. To maintain glycolytic flux and…”
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Modeling Dose and Schedule Effects of AZD2811 Nanoparticles Targeting Aurora B Kinase for Treatment of Diffuse Large B-cell Lymphoma by Floc'h, Nicolas, Ashton, Susan, Ferguson, Douglas, Taylor, Paula, Carnevalli, Larissa S, Hughes, Adina M, Harris, Emily, Hattersley, Maureen, Wen, Shenghua, Curtis, Nicola J, Pilling, James E, Young, Lucy A, Maratea, Kim, Pease, Elizabeth J, Barry, Simon T

“…Barasertib (AZD1152), a pro-drug of the highly potent and selective Aurora B kinase inhibitor AZD2811, showed promising clinical activity in…”
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Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles by Floc'h, Nicolas, Ashton, Susan, Taylor, Paula, Trueman, Dawn, Harris, Emily, Odedra, Rajesh, Maratea, Kim, Derbyshire, Nicola, Caddy, Jacqueline, Jacobs, Vivien N, Hattersley, Maureen, Wen, Shenghua, Curtis, Nicola J, Pilling, James E, Pease, Elizabeth J, Barry, Simon T

“…Barasertib (AZD1152), a highly potent and selective aurora kinase B inhibitor, gave promising clinical activity in elderly acute myeloid leukemia (AML)…”
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Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3 by Boyd, Scott, Brookfield, Joanna L, Critchlow, Susan E, Cumming, Iain A, Curtis, Nicola J, Debreczeni, Judit, Degorce, Sébastien L, Donald, Craig, Evans, Nicola J, Groombridge, Sam, Hopcroft, Philip, Jones, Neil P, Kettle, Jason G, Lamont, Scott, Lewis, Hilary J, MacFaull, Philip, McLoughlin, Sheila B, Rigoreau, Laurent J. M, Smith, James M, St-Gallay, Steve, Stock, Julie K, Turnbull, Andrew P, Wheatley, Edward R, Winter, Jon, Wingfield, Jonathan

“…A weak screening hit with suboptimal physicochemical properties was optimized against PFKFB3 kinase using critical structure-guided insights. The resulting…”
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Irreversible nephrotoxicity from demeclocycline in the treatment of hyponatramia by Curtis, Nicola J., van Heyningen, Charles, Turner, John J.

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Irreversible nephrotoxicity from demeclocycline in the treatment of hyponatremia by Curtis, Nicola J, van Heyningen, Charles, Turner, John J

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