Search Results - "Curtis, Kate M."

Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation by Frise, Matthew C., Holdsworth, David A., Johnson, Andrew W., Chung, Yu Jin, Curtis, M. Kate, Cox, Pete J., Clarke, Kieran, Tyler, Damian J., Roberts, David J., Ratcliffe, Peter J., Dorrington, Keith L., Robbins, Peter A.

“…Iron deficiency impairs skeletal muscle metabolism. The underlying mechanisms are incompletely characterised, but animal and human experiments suggest the…”
Get full text

Publisher Correction: Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation by Frise, Matthew C., Holdsworth, David A., Johnson, Andrew W., Chung, Yu Jin, Curtis, M. Kate, Cox, Pete J., Clarke, Kieran, Tyler, Damian J., Roberts, David J., Ratcliffe, Peter J., Dorrington, Keith L., Robbins, Peter A.

Get full text

Iron-Deficiency Anemia Results in Transcriptional and Metabolic Remodeling in the Heart Toward a Glycolytic Phenotype by Chung, Yu Jin, Swietach, Pawel, Curtis, M Kate, Ball, Vicky, Robbins, Peter A, Lakhal-Littleton, Samira

“…Iron deficiency is the most prevalent micronutrient disorder globally. When severe, iron deficiency leads to anemia, which can be deleterious to cardiac…”
Get full text

L-Carnitine Stimulates In Vivo Carbohydrate Metabolism in the Type 1 Diabetic Heart as Demonstrated by Hyperpolarized MRI by Savic, Dragana, Ball, Vicky, Curtis, M Kate, Sousa Fialho, Maria da Luz, Timm, Kerstin N, Hauton, David, West, James, Griffin, Julian, Heather, Lisa C, Tyler, Damian J

“…The diabetic heart is energetically and metabolically abnormal, with increased fatty acid oxidation and decreased glucose oxidation. One factor contributing to…”
Get full text

Intravenous iron delivers a sustained (8‐week) lowering of pulmonary artery pressure during exercise in healthy older humans by Cheng, Hung‐Yuan, Frise, Matthew C., Curtis, M. Kate, Bart, Nicole K., Petousi, Nayia, Talbot, Nick P., Balanos, George M., Robbins, Peter A., Dorrington, Keith L.

“…In older individuals, pulmonary artery pressure rises markedly during exercise, probably due in part to increased pulmonary vascular resistance and in part to…”
Get full text

Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans by Talbot, Nick P., Croft, Quentin P., Curtis, M. Kate, Turner, Brandon E., Dorrington, Keith L., Robbins, Peter A., Smith, Thomas G.

“…Hypoxia causes an increase in pulmonary artery pressure. Gene expression controlled by the hypoxia‐inducible factor (HIF) family of transcription factors plays…”
Get full text

Clinical iron deficiency disturbs normal human responses to hypoxia by Frise, Matthew C, Cheng, Hung-Yuan, Nickol, Annabel H, Curtis, M Kate, Pollard, Karen A, Roberts, David J, Ratcliffe, Peter J, Dorrington, Keith L, Robbins, Peter A

“…Iron bioavailability has been identified as a factor that influences cellular hypoxia sensing, putatively via an action on the hypoxia-inducible factor (HIF)…”
Get full text

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia by Rohm, Maria, Savic, Dragana, Ball, Vicky, Curtis, M Kate, Bonham, Sarah, Fischer, Roman, Legrave, Nathalie, MacRae, James I, Tyler, Damian J, Ashcroft, Frances M

“…Diabetes is a well-established risk factor for heart disease, leading to impaired cardiac function and a metabolic switch toward fatty acid usage. In this…”
Get full text

Hyperpolarized magnetic resonance shows that the anti‐ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post‐ischemic function in the diabetic heart by Savic, Dragana, Ball, Vicky, Holzner, Lorenz, Hauton, David, Timm, Kerstin N., Curtis, M. Kate, Heather, Lisa C., Tyler, Damian J.

“…The diabetic heart has a decreased ability to metabolize glucose. The anti‐ischemic drug meldonium may provide a route to counteract this by reducing…”
Get full text

A high-throughput ratiometric method for imaging hypertrophic growth in cultured primary cardiac myocytes by Loonat, Aminah A., Curtis, M. Kate, Richards, Mark A., Nunez-Alonso, Graciela, Michl, Johanna, Swietach, Pawel

“…Maladaptive hypertrophy of cardiac myocytes increases the risk of heart failure. The underlying signaling can be triggered and interrogated in cultured…”
Get full text

Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH by Wilson, Abigail D, Richards, Mark A, Curtis, M Kate, Gunadasa-Rohling, Mala, Monterisi, Stefania, Loonat, Aminah A, Miller, Jack J, Ball, Vicky, Lewis, Andrew, Tyler, Damian J, Moshnikova, Anna, Andreev, Oleg A, Reshetnyak, Yana K, Carr, Carolyn, Swietach, Pawel

“…In cardiomyocytes, acute disturbances to intracellular pH (pHi) are promptly corrected by a system of finely tuned sarcolemmal acid-base transporters. However,…”
Get full text

Developing a future protocol for measuring spider biodiversity in pastures in New Zealand by Curtis, Kate M., Paterson, Adrian M., Malumbres-Olarte, Jagoba, Vink, Cor J., Ross, James G.

“…Arthropods are often ignored or under-sampled in biodiversity and conservation assessments because of their large diversity, small size and lack of taxonomic…”
Get full text

Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia by Bart, Nicole K, Curtis, M Kate, Cheng, Hung-Yuan, Hungerford, Sara L, McLaren, Ross, Petousi, Nayia, Dorrington, Keith L, Robbins, Peter A

“…Sustained hypoxia over several hours induces a progressive rise in pulmonary artery systolic pressure (PASP). Administration of intravenous iron immediately…”
Get full text

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart by Hulikova, Alzbeta, Park, Kyung Chan, Loonat, Aminah A., Gunadasa-Rohling, Mala, Curtis, M. Kate, Chung, Yu Jin, Wilson, Abigail, Carr, Carolyn A., Trafford, Andrew W., Fournier, Marjorie, Moshnikova, Anna, Andreev, Oleg A., Reshetnyak, Yana K., Riley, Paul R., Smart, Nicola, Milne, Thomas A., Crump, Nicholas T., Swietach, Pawel

“…Cardiac contractile strength is recognised as being highly pH-sensitive, but less is known about the influence of pH on cardiac gene expression, which may…”
Get full text

Effects of modest iron loading on iron indices in healthy individuals by Bart, Nicole K, Hungerford, Sara L, Curtis, M Kate, Cheng, Hung-Yuan, Southern, Jennifer L, Petousi, Nayia, Dorrington, Keith L, Robbins, Peter A

“…Intravenous iron administration is typically indicated in individuals who have iron deficiency refractory to oral iron. However, in certain chronic disease…”
Get full text

A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease by Nickol, Annabel H, Frise, Matthew C, Cheng, Hung-Yuan, McGahey, Anne, McFadyen, Bethan M, Harris-Wright, Tara, Bart, Nicole K, Curtis, M Kate, Khandwala, Shivani, O'Neill, David P, Pollard, Karen A, Hardinge, F Maxine, Rahman, Najib M, Armitage, Andrew E, Dorrington, Keith L, Drakesmith, Hal, Ratcliffe, Peter J, Robbins, Peter A

“…ObjectivesChronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Iron deficiency, with or without anaemia, is associated…”
Get full text