Search Results - "Curtis, Joseph E."

Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity by Yearley, Eric J., Godfrin, Paul D., Perevozchikova, Tatiana, Zhang, Hailiang, Falus, Peter, Porcar, Lionel, Nagao, Michihiro, Curtis, Joseph E., Gawande, Pradad, Taing, Rosalynn, Zarraga, Isidro E., Wagner, Norman J., Liu, Yun

“…Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. It is hypothesized that some concentrated mAb solutions exhibit formation of a solution…”
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Structural model of an mRNA in complex with the bacterial chaperone Hfq by Peng, Yi, Curtis, Joseph E., Fang, Xianyang, Woodson, Sarah A.

“…The Sm-like protein Hfq (host factor Q-beta phage) facilitates regulation by bacterial small noncoding RNAs (sRNAs) in response to stress and other…”
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Role of Molecular Flexibility and Colloidal Descriptions of Proteins in Crowded Environments from Small-Angle Scattering by Castellanos, Maria Monica, Clark, Nicholas J, Watson, Max C, Krueger, Susan, McAuley, Arnold, Curtis, Joseph E

“…Small-angle scattering is a powerful technique to study molecular conformation and interactions of proteins in solution and in amorphous solids. We have…”
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Protein Adsorption and Layer Formation at the Stainless Steel–Solution Interface Mediates Shear-Induced Particle Formation for an IgG1 Monoclonal Antibody by Kalonia, Cavan K, Heinrich, Frank, Curtis, Joseph E, Raman, Sid, Miller, Maria A, Hudson, Steven D

“…Passage of specific protein solutions through certain pumps, tubing, and/or filling nozzles can result in the production of unwanted subvisible protein…”
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SEC ‐ SAXS / MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations by Smith, Kyle P., Chakravarthy, Srinivas, Rahi, Amit, Chakraborty, Manas, Vosberg, Kristen M., Tonelli, Marco, Plach, Maximilian G., Grigorescu, Arabela A., Curtis, Joseph E., Varma, Dileep

“…Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to…”
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Linkage-specific conformational ensembles of non-canonical polyubiquitin chains by Castañeda, Carlos A, Chaturvedi, Apurva, Camara, Christina M, Curtis, Joseph E, Krueger, Susan, Fushman, David

“…Polyubiquitination is a critical protein post-translational modification involved in a variety of processes in eukaryotic cells. The molecular basis for…”
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Characterization of the NISTmAb Reference Material using small-angle scattering and molecular simulation by Castellanos, Maria Monica, Howell, Steven C, Gallagher, D. Travis, Cu

“…Both conformational and colloidal stability of therapeutic proteins must be closely monitored and thoroughly characterized to assess the long-term viability of…”
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Linkage via K27 Bestows Ubiquitin Chains with Unique Properties among Polyubiquitins by Castañeda, Carlos A., Dixon, Emma K., Walker, Olivier, Chaturvedi, Apurva, Nakasone, Mark A., Curtis, Joseph E., Reed, Megan R., Krueger, Susan, Cropp, T. Ashton, Fushman, David

“…Polyubiquitination, a critical protein post-translational modification, signals for a diverse set of cellular events via the different isopeptide linkages…”
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Investigating Structure and Dynamics of Proteins in Amorphous Phases Using Neutron Scattering by Castellanos, Maria Monica, McAuley, Arnold, Curtis, Joseph E.

“…In order to increase shelf life and minimize aggregation during storage, many biotherapeutic drugs are formulated and stored as either frozen solutions or…”
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Small-Angle Neutron Scattering Study of a Monoclonal Antibody Using Free-Energy Constraints by Clark, Nicholas J, Zhang, Hailiang, Krueger, Susan, Lee, Hyo Jin, Ketchem, Randal R, Kerwin, Bruce, Kanapuram, Sekhar R, Treuheit, Michael J, McAuley, Arnold, Curtis, Joseph E

“…Monoclonal antibodies (mAbs) contain hinge-like regions that enable structural flexibility of globular domains that have a direct effect on biological…”
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Probing the Average Local Structure of Biomolecules Using Small-Angle Scattering and Scaling Laws by Watson, Max C., Curtis, Joseph E.

“…Small-angle neutron and x-ray scattering have become invaluable tools for probing the nanostructure of molecules in solution. It was recently shown that the…”
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Effects of Monovalent Salt on Protein-Protein Interactions of Dilute and Concentrated Monoclonal Antibody Formulations by Xu, Amy Y, Clark, Nicholas J, Pollastrini, Joseph, Espinoza, Maribel, Kim, Hyo-Jin, Kanapuram, Sekhar, Kerwin, Bruce, Treuheit, Michael J, Krueger, Susan, McAuley, Arnold, Curtis, Joseph E

“…In this study, we used sodium chloride (NaCl) to extensively modulate non-specific protein-protein interactions (PPI) of a humanized anti-streptavidin…”
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Solution Conformations of Prototype Foamy Virus Integrase and Its Stable Synaptic Complex with U5 Viral DNA by Gupta, Kushol, Curtis, Joseph E., Krueger, Susan, Hwang, Young, Cherepanov, Peter, Bushman, Frederic D., Van Duyne, Gregory D.

“…Using small-angle X-ray and neutron scattering (SAXS/SANS), in combination with analytical centrifugation and light scattering, we have determined the solution…”
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Intermediate scattering functions of a rigid body monoclonal antibody protein in solution studied by dissipative particle dynamic simulation by Zhai, Yanqin, Martys, Nicos S., George, William L., Curtis, Joseph E., Nayem, Jannatun, Z, Y, Liu, Yun

“…In the past decade, there was increased research interest in studying internal motions of flexible proteins in solution using Neutron Spin Echo (NSE) as NSE…”
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Studying Excipient Modulated Physical Stability and Viscosity of Monoclonal Antibody Formulations Using Small-Angle Scattering by Xu, Amy Yuanyuan, Castellanos, Maria Monica, Mattison, Kevin, Krueger, Susan, Curtis, Joseph E

“…Excipients are substances that are added to therapeutic products to improve stability, bioavailability, and manufacturability. Undesirable protein–protein…”
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Neutron Reflectometry Study of the Conformation of HIV Nef Bound to Lipid Membranes by Kent, Michael S., Murton, Jaclyn K., Sasaki, Darryl Y., Satija, Sushil, Akgun, Bulent, Nanda, Hirsh, Curtis, Joseph E., Majewski, Jaroslaw, Morgan, Christopher R., Engen, John R.

“…Nef is an HIV-1 accessory protein that directly contributes to AIDS progression. Nef is myristoylated on the N-terminus, associates with membranes, and may…”
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Characterization of Monoclonal Antibody-Protein Antigen Complexes Using Small-Angle Scattering and Molecular Modeling by Castellanos, Maria Monica, Snyder, James A, Lee, Melody, Chakravarthy, Srinivas, Clark, Nicholas J, McAuley, Arnold, Curtis, Joseph E

“…The determination of monoclonal antibody interactions with protein antigens in solution can lead to important insights guiding physical characterization and…”
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SASSIE: A program to study intrinsically disordered biological molecules and macromolecular ensembles using experimental scattering restraints by Curtis, Joseph E., Raghunandan, Sindhu, Nanda, Hirsh, Krueger, Susan

“…A program to construct ensembles of biomolecular structures that are consistent with experimental scattering data are described. Specifically, we generate an…”
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Phase Behavior of Poloxamer 188 Aqueous Solutions at Subzero Temperatures: A Neutron and X‑ray Scattering Study by Yuan, Xiaoda, Krueger, Susan, Sztucki, Michael, Jones, Ronald L, Curtis, Joseph E, Shalaev, Evgenyi

“…Phase transitions of poloxamer 188 (P188) aqueous solutions at freezing temperatures are investigated using small-angle neutron scattering (SANS) and small-…”
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Styrene–Maleic Acid Copolymer Nanodiscs to Determine the Shape of Membrane Proteins by Jeong, Cheol, Franklin, Ryan, Edler, Karen J, Vanommeslaeghe, Kenno, Krueger, Susan, Curtis, Joseph E

“…Lipid nanodiscs can be used to solubilize functional membrane proteins (MPs) in nativelike environments. Thus, they are promising reagents that have been…”
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