Search Results - "Curtis, JR"
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Model-Based Approach Shows ON Pathway Afferents Elicit a Transient Decrease of V1 Responses
Published in The Journal of neuroscience (15-03-2023)“…Neurons in the primary visual cortex (V1) receive excitation and inhibition from distinct parallel pathways processing lightness (ON) and darkness (OFF). V1…”
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Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery
Published in Biosensors & bioelectronics (15-10-2024)“…Continuous oxygenation monitoring of machine-perfused organs or transposed autologous tissue is not currently implemented in clinical practice. Oxygenation is…”
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3
Maximum entropy models for antibody diversity
Published in Proceedings of the National Academy of Sciences - PNAS (23-03-2010)“…Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building…”
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4
Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay
Published in Nature biotechnology (01-03-2012)“…An improved understanding of enhancers in mammalian genomes could facilitate the design of new regulatory elements. Melnikov et al . synthesize thousands of…”
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5
Estimating receptive fields of simple and complex cells in early visual cortex: A convolutional neural network model with parameterized rectification
Published in PLoS computational biology (31-05-2024)“…Neurons in the primary visual cortex respond selectively to simple features of visual stimuli, such as orientation and spatial frequency. Simple cells, which…”
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6
Immunosuppressant drug monitor: A non-invasive device to measure tacrolimus level in the saliva of transplanted patients
Published in International journal of pharmaceutics (25-03-2024)“…[Display omitted] Solid organ and vascularized composite allograft transplantation are pivotal in enhancing both life expectancy and quality of life. However,…”
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7
Information flow and optimization in transcriptional regulation
Published in Proceedings of the National Academy of Sciences - PNAS (26-08-2008)“…In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor…”
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Using deep sequencing to characterize the biophysical mechanism of a transcriptional regulatory sequence
Published in Proceedings of the National Academy of Sciences - PNAS (18-05-2010)“…Cells use protein-DNA and protein-protein interactions to regulate transcription. A biophysical understanding of this process has, however, been limited by the…”
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Manufacturing demonstration of microbially mediated zinc sulfide nanoparticles in pilot-plant scale reactors
Published in Applied microbiology and biotechnology (01-09-2016)“…The thermophilic anaerobic metal-reducing bacterium Thermoanaerobacter sp. X513 efficiently produces zinc sulfide (ZnS) nanoparticles (NPs) in laboratory-scale…”
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10
A Systematic Review of the Reported Complications Related to Facial and Upper Extremity Vascularized Composite Allotransplantation
Published in The Journal of surgical research (01-01-2023)“…Twenty three years after the first successful upper extremity transplantation, the role of vascularized composite allotransplantation (VCA) in the world of…”
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11
Secondary Surgery after Lower Extremity Free Flap Reconstruction
Published in Plastic and reconstructive surgery (1963) (01-11-2023)“…Microsurgical free tissue transfer may be the only reconstructive option for lower extremity limb salvage. However, the functional and aesthetic results…”
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Genitourinary vascularized composite allotransplantation for gender affirmation in trans men: An anatomical feasibility study
Published in Journal of plastic, reconstructive & aesthetic surgery (01-08-2023)“…Gender affirmation in trans men requires multiple staged procedures. The final masculinizing step involves phalloplasty or metoidioplasty and further…”
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13
Machine Perfusion Enables 24-h Preservation of Vascularized Composite Allografts in a Swine Model of Allotransplantation
Published in Transplant international (15-05-2024)“…The current gold standard for preserving vascularized composite allografts (VCA) is 4°C static cold storage (SCS), albeit muscle vulnerability to ischemia can…”
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Acute Rejection Rates in Vascularized Composite Allografts: A Systematic Review of Case Reports
Published in The Journal of surgical research (01-06-2024)“…Vascularized Composite Allografts (VCA) are usually performed in a full major histocompatibility complex mismatch setting, with a risk of acute rejection…”
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15
Cutaneous leukocyte lineages in tolerant large animal and immunosuppressed clinical vascularized composite allograft recipients
Published in American journal of transplantation (01-02-2021)“…Vascularized composite allografts (VCAs) can restore fully functional anatomic units in patients with limb amputations or severe facial tissue loss. However,…”
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Exceeding the Limits of Static Cold Storage in Limb Transplantation Using Subnormothermic Machine Perfusion
Published in Journal of reconstructive microsurgery (01-06-2023)“…For 50 years, static cold storage (SCS) has been the gold standard for solid organ preservation in transplantation. Although logistically convenient, this…”
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17
Biochemical and molecular predictors for prognosis in nonketotic hyperglycinemia
Published in Annals of neurology (01-10-2015)“…Objective Nonketotic hyperglycinemia is a neurometabolic disorder characterized by intellectual disability, seizures, and spasticity. Patients with attenuated…”
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VCA supercooling in a swine partial hindlimb model
Published in Scientific reports (01-06-2024)“…Vascularized composite allotransplantations are complex procedures with substantial functional impact on patients. Extended preservation of VCAs is of major…”
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Genetically modified porcine split-thickness skin grafts as an alternative to allograft for provision of temporary wound coverage: preliminary characterization
Published in Burns (01-05-2015)“…Abstract Temporary coverage of severely burned patients with cadaver allograft skin represents an important component of burn care, but is limited by…”
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Visual perception of texture regularity: Conjoint measurements and a wavelet response-distribution model
Published in PLoS computational biology (01-10-2021)“…Texture regularity, such as the repeating pattern in a carpet, brickwork or tree bark, is a ubiquitous feature of the visual world. The perception of…”
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