Search Results - "Curtin, Leslie"

Dose-Dependent Sorafenib-Induced Immunosuppression Is Associated with Aberrant NFAT Activation and Expression of PD-1 in T Cells by Iyer, Renuka V, Maguire, Orla, Kim, Minhyung, Curtin, Leslie I, Sexton, Sandra, Fisher, Daniel T, Schihl, Sarah A, Fetterly, Gerald, Menne, Stephan, Minderman, Hans

“…The multikinase inhibitor sorafenib is the only standard first-line therapy for hepatocellular carcinoma (HCC). Here, we report the dose-dependent effects of…”
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A Translational Hepatic Artery Infusion (HAI) Model for Hepatocellular Carcinoma in Woodchucks by Kim, Minhyung, Powers, Colin A., Curtin, Leslie I., Fisher, Daniel T., Sexton, Sandra, Gurova, Katerina V., Skitzki, Joseph J., Iyer, Renuka V.

“…Woodchucks (Marmota monax) are a well-accepted animal model for the investigation of spontaneous hepatocellular carcinoma (HCC). As HCC tumors obtain nutrient…”
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Robot‐assisted approach to ‘W’‐configuration urinary diversion: a step‐by‐step technique by Hussein, Ahmed A., Ahmed, Youssef E., Kozlowski, Justen D., May, Paul R., Nyquist, John, Sexton, Sandra, Curtin, Leslie, Peabody, James O., Abol‐Enein, Hassan, Guru, Khurshid A.

“…Objective To describe a detailed step‐by‐step approach of our technique for robot‐assisted intracorporeal ‘W’‐configuration orthotopic ileal neobladder…”
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Photobac derived from bacteriochlorophyll-a shows potential for treating brain tumor in animal models by photodynamic therapy with desired pharmacokinetics and limited toxicity in rats and dogs by Durrani, Farukh A., Cacaccio, Joseph, Turowski, Steven G., Dukh, Mykhaylo, Bshara, Wiam, Curtin, Leslie, Sexton, Sandra, Spernyak, Joseph A., Pandey, Ravindra K.

“…Photobac is a near infrared photosensitizer (PS) derived from naturally occurring bacteriochlorophyll- a, with a potential for treating a variety of cancer…”
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Spatiotemporal Optoacoustic Mapping of Tumor Hemodynamics in a Clinically Relevant Orthotopic Rabbit Model of Head and Neck Cancer by Rich, Laurie J, Sexton, Sandra, Curtin, Leslie, Seshadri, Mukund

“…The purpose of this study was to investigate the usefulness of photoacoustic imaging (PAI) for spatiotemporal mapping of tumor hemodynamics in a rabbit model…”
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Succinate dehydrogenase inversely regulates red cell distribution width and healthy life span in chronically hypoxic mice by Baysal, Bora E., Alahmari, Abdulrahman A., Rodrick, Tori C., Tabaczynski, Debra, Curtin, Leslie, Seshadri, Mukund, Jones, Drew R., Sexton, Sandra

“…Increased red cell distribution width (RDW), which measures erythrocyte mean corpuscular volume (MCV) variability (anisocytosis), has been linked to early…”
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Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells by Povinelli, Benjamin J, Kokolus, Kathleen M, Eng, Jason W-L, Dougher, Christopher W, Curtin, Leslie, Capitano, Maegan L, Sailsbury-Ruf, Christi T, Repasky, Elizabeth A, Nemeth, Michael J

“…The production of new blood cells relies on a hierarchical network of hematopoietic stem and progenitor cells (HSPCs). To maintain lifelong hematopoiesis,…”
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Evaluation of Buprenorphine in a Postoperative Pain Model in Rats by Curtin, Leslie I, Grakowsky, Julie A, Suarez, Mauricio, Thompson, Alexis C, DiPirro, Jean M, Martin, Lisa B.E, Kristal, Mark B

“…We evaluated the commonly prescribed analgesic buprenorphine in a postoperative pain model in rats, assessing acute postoperative pain relief, rebound…”
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In Vivo Models for Studying Interstitial Photodynamic Therapy of Locally Advanced Cancer by Shafirstein, Gal, Oakley, Emily, Hamilton, Sasheen, Habitzruther, Michael, Chamberlain, Sarah, Sexton, Sandra, Curtin, Leslie, Bellnier, David A

“…Interstitial photodynamic therapy (I-PDT) is a promising therapy considered for patients with locally advanced cancer. In I-PDT, laser fibers are inserted into…”
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Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer by Shafirstein, Gal, Bellnier, David A., Oakley, Emily, Hamilton, Sasheen, Habitzruther, Michael, Tworek, Lawrence, Hutson, Alan, Spernyak, Joseph A., Sexton, Sandra, Curtin, Leslie, Turowski, Steven G., Arshad, Hassan, Henderson, Barbara

“…Background Currently delivered light dose (J/cm 2 ) is the principal parameter guiding interstitial photodynamic therapy (I-PDT) of refractory locally advanced…”
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Irradiance, Photofrin® Dose and Initial Tumor Volume are Key Predictors of Response to Interstitial Photodynamic Therapy of Locally Advanced Cancers in Translational Models by Oakley, Emily, Bellnier, David, Hutson, Alan, Cooper, Hannah, Habitzruther, Michael, Sexton, Sandra, Curtin, Leslie, Tworek, Lawrence, Mallory, Matthew, Henderson, Barbara, Shafirstein, Gal

“…The objective of the present study was to develop a predictive model for Photofrin®‐mediated interstitial photodynamic therapy (I‐PDT) of locally advanced…”
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Tumor-Avid 3‑(1′-Hexyloxy)ethyl-3-devinylpyrpyropheophorbide‑a (HPPH)-3Gd(III)tetraxetan (DOTA) Conjugate Defines Primary Tumors and Metastases by Cheruku, Ravindra R., Turowski, Steven G., Durrani, Farukh A., Tabaczynski, Walter A., Cacaccio, Joseph, Missert, Joseph R., Curtin, Leslie, Sexton, Sandra, Alberico, Ronald, Hendler, Craig M., Spernyak, Joseph A., Grossman, Zachary, Pandey, Ravindra K.

“…3-(1′-Hexyloxyethyl)-3-devinylpyropheophorbide-a (HPPH or Photochlor), a tumor-avid chlorophyll a derivative currently undergoing human clinical trials, was…”
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In vivo toxicity, metabolism and pharmacokinetic properties of FAK inhibitor 14 or Y15 (1, 2, 4, 5-benzenetetramine tetrahydrochloride) by Golubovskaya, Vita, Curtin, Leslie, Groman, Adrienne, Sexton, Sandra, Cance, William G.

“…Y15 or inhibitor 14 (1,2,4,5-benzenetetramine tetrahydrochloride) is a potent and specific inhibitor of focal adhesion kinase that inhibits its…”
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Highlights on the imaging (nuclear/fluorescence) and phototherapeutic potential of a tri-functional chlorophyll-a analog with no significant toxicity in mice and rats by Srivatsan, Avinash, Pera, Paula, Joshi, Penny, Marko, Aimee J., Durrani, Farukh, Missert, Joseph R., Curtin, Leslie, Sexton, Sandra, Yao, Rutao, Sajjad, Munawwar, Pandey, Ravindra K.

“…Herein we report the positron emission tomography (PET) imaging potential of a 124I-labeled radiopharmaceutical (PET-ONCO). In tumored mice, it shows high…”
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Clinically and orally compatible formulation-manufactured DDX5 (p68)-targeting molecular glue FL118 products exhibit low toxicity but high efficacy against human cancer by Ling, Xiang, Wu, Wenjie, Yan, Li, Curtin, Leslie, Farrauto, Melanie M., Sexton, Sandra, Jamroze, Anmbreen, Yu, Changjun, Fountzilas, Christos, Tang, Dean G., Li, Fengzhi

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An Optical Surface Applicator for Intraoperative Photodynamic Therapy by Chamberlain, Sarah, Bellnier, David, Yendamuri, Sai, Lindenmann, Joerg, Demmy, Todd, Nwogu, Chukwumere, Ramer, Max, Tworek, Larry, Oakley, Emily, Mallory, Matthew, Carlsen, Lindsey, Sexton, Sandra, Curtin, Leslie, Shafirstein, Gal

“…Background and Objectives Intraoperative photodynamic therapy (IO‐PDT) is typically administered by a handheld light source. This can result in uncontrolled…”
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Abstract 809: A novel woodchuck model of hepatic artery infusion (HAI) with FACT complex targeted drug CBL0137 by Kim, Minhyung, Curtin, Leslie I., Powers, Colin A., Sexton, Sandra, Gurova, Katerina V., Gudkov, Andrei V., Iyer, Renuka V.

“…Abstract Background: The liver has unique anatomy in that most blood flow to normal hepatocytes is derived from the portal venous system, while liver tumors…”
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Abstract 2420: Interstitial chemo-phototherapy for treatment of locally advanced hepatocellular carcinoma: A preclinical study by Oakley, Emily, Kim, Minhyung, Ghosh, Sanjana, Kutscher, Hilliard, Lovell, Jonathan, Curtin, Leslie, Sexton, Sandra, Hutson, Alan, Shafirstein, Gal

“…Abstract Background Patients with hepatocellular carcinoma (HCC) have a poor prognosis with a 5-year survival rate of only 35%. Patients with locally advanced…”
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Preclinical toxicology studies with Y15, a novel focal adhesion kinase (FAK) inhibitor by Cance, William G., Curtin, Leslie, Buitrago, Sandra, Golubovskaya, Vita

“…Abstract only e13561 Background: Focal Adhesion Kinase (FAK) is overexpressed in many types of tumors and plays a major role in survival signaling. Recently,…”
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The Influence Of Metabolic Stress On Radiosensitivity Of Hematopoietic Stem and Progenitor Cells by Povinelli, Benjamin, Kokolus, Kathleen M, Curtin, Leslie, Repasky, Elizabeth A, Nemeth, Michael

“…Healthy hematopoiesis requires maintenance of the population size and function of hematopoietic stem and progenitor cells (HSPC) throughout life, in part…”
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