Search Results - "Curti, B"

Initial cohort expansion results of sustained arginine depletion with pegzilarginase in melanoma patients in a phase I advanced solid tumor trial by Chmielowski, B., Gordon, M., Buchbinder, E.I., Sullivan, R.J., Cohen, J.V., Curti, B.D., Davar, D., Homsi, J., Komatsubara, K.M., Lara-Guerra, H., Alters, S.E., Ferrati, S., Eckert, S., Rowlinson, S.W., Wooldridge, J.E., Ribas, A., Carvajal, R.D.

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Phase Ib KEYNOTE-200: A study of an intravenously delivered oncolytic virus, coxsackievirus A21 in combination with pembrolizumab in advanced NSCLC and bladder cancer patients by Rudin, C.M., Pandha, H.S., Gupta, S., Zibelman, M.R., Akerley, W., Day, D., Hill, A.G., Sanborn, R.E., O'Day, S.J., Clay, T.D., Wright, G.M., Jennens, R., Gerber, D.E., Rosenberg, J.E., Ralph, C., Campbell, D.C., Curti, B.D., Schmidt, E.V., Grose, M., Shafren, D.

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3335 Intralesional administration of Coxsackievirus A21 (CVA21) oncolytic virus immunotherapy in patients with advanced melanoma induces durable tumor responses by Andtbacka, R.H.I, Curti, B, Kaufman, H.L, Daniels, G.A, Nemunaitis, J.J, Spitler, L.E, Hallmeyer, S, Lutzky, J, Schultz, S, Whitman, E.D, Zhou, K, Karpathy, R, Weisberg, J.I, Shafren, D

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3336 Phase II CALM extension study: Enhanced immune-cell infiltration within the tumour micro-environment of patients with advanced melanoma following intralesional delivery of Coxsackievirus A21 by Andtbacka, R.H.I, Curti, B, Hallmeyer, S, Feng, Z, Paustian, C, Bifulco, C, Fox, B, Grose, M, Davies, B, Karpathy, R, Shafren, D

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Overall survival by clinical risk category for high dose interleukin-2 (HD IL-2) treated patients with metastatic renal cell cancer (mRCC): data from the PROCLAIMSM registry by Fishman, M., Dutcher, J. P., Clark, J. I., Alva, A., Miletello, G. P., Curti, B., Agarwal, Neeraj, Hauke, R., Mahoney, K. M., Moon, H., Treisman, J., Tykodi, S. S., Daniels, G., Morse, M. A., Wong, M. K. K., Kaufman, H., Gregory, N., McDermott, D. F.

“…Background Prognostic scoring systems are used to estimate the risk of mortality from metastatic renal cell carcinoma (mRCC). Outcomes from different therapies…”
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Glutamate synthase: a complex iron-sulfur flavoprotein by Vanoni, M A, Curti, B

“…Glutamate synthase is a complex iron-sulfur flavoprotein that forms L-glutamate from L-glutamine and 2-oxoglutarate. It participates with glutamine synthetase…”
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Glutamate synthase: a fascinating pathway from L-glutamine to L-glutamate by van den Heuvel, R H H, Curti, B, Vanoni, M A, Mattevi, A

“…Glutamate synthase is a multicomponent iron-sulfur flavoprotein belonging to the class of N-terminal nucleophile amidotransferases. It catalyzes the conversion…”
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Crystal Structure of D-Amino Acid Oxidase: A Case of Active Site Mirror-Image Convergent Evolution with Flavocytochrome b2 by Mattevi, Andrea, Vanoni, Maria Antonietta, Todone, Flavia, Rizzi, Menico, Teplyakov, Alex, Coda, Alessandro, Bolognesi, Martino, Curti, Bruno

“…D-amino acid oxidase is the prototype of the FAD-dependent oxidases. It catalyses the oxidation of D-amino acids to the corresponding α -ketoacids. The…”
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Alterations in T cell receptor and signal transduction molecules in melanoma patients by ZEA, A. H, CURTI, B. D, OCHOA, A. C, LONGO, D. L, ALVORD, W. G, STROBL, S. L, MIZOGUCHI, H, CREEKMORE, S. P, O'SHEA, J. J, POWERS, G. C, URBA, W. J

“…We have recently described molecular changes in T cells from tumor-bearing patients that are associated with depressed immune function. The present work…”
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Identifying and quantitating FAD and FMN in simple and in iron-sulfur-containing flavoproteins by Aliverti, A, Curti, B, Vanoni, M A

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Cross-Talk and Ammonia Channeling between Active Centers in the Unexpected Domain Arrangement of Glutamate Synthase by Binda, Claudia, Bossi, Roberto T., Wakatsuki, Soichi, Arzt, Steffi, Coda, Alessandro, Curti, Bruno, Vanoni, Maria A., Mattevi, Andrea

“…Introduction: The complex iron-sulfur flavoprotein glutamate synthase catalyses the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine, a…”
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Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients : changes during treatment by CURTI, B. D, URBA, W. J, ALVORD, W. G, JANIK, J. E, SMITH, J. W, MADARA, K, LONGO, D. L

“…Interstitial pressure (IP) is a physiological variable that may have its greatest influence on the transport of high-molecular-weight therapeutic agents. IP in…”
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The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies by Smith, 2nd, J W, Urba, W J, Curti, B D, Elwood, L J, Steis, R G, Janik, J E, Sharfman, W H, Miller, L L, Fenton, R G, Conlon, K C

“…A phase I trial was undertaken because interleukin-1 alpha (IL-1 alpha) possesses antiproliferative, immunostimulatory, antiinfection, myeloprotective, and…”
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Phase I trial of anti-CD3-stimulated CD4+ T cells, infusional interleukin-2, and cyclophosphamide in patients with advanced cancer by Curti, B D, Ochoa, A C, Powers, G C, Kopp, W C, Alvord, W G, Janik, J E, Gause, B L, Dunn, B, Kopreski, M S, Fenton, R, Zea, A, Dansky-Ullmann, C, Strobl, S, Harvey, L, Nelson, E, Sznol, M, Longo, D L

“…We performed a phase I trial to determine whether in vivo expansion of activated CD4+ T cells was possible in cancer patients. 111Indium labeling was used to…”
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Hepatobiliary lymphoepithelioma-like carcinoma associated with Epstein-Barr virus by VORTMEYER, A. O, KINGMA, D. W, FENTON, R. G, CURTI, B. D, JAFFE, E. S, DURAY, P. H

“…We describe the clinical and pathologic features of a lymphoepithelioma-like carcinoma (LELC) that originated in the hepatobiliary system. A woman, aged 71…”
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The Effects of Treatment with Interleukin-1α on Platelet Recovery after High-Dose Carboplatin by Smith, John W, Longo, Dan L, Alvord, W. Gregory, Janik, John E, Sharfman, William H, Gause, Barry L, Curti, Brendan D, Creekmore, Stephen P, Holmlund, Jon T, Fenton, Robert G, Sznol, Mario, Miller, Langdon L, Shimizu, Masanao, Oppenheim, Joost J, Fiem, Shelby J, Hursey, Jean C, Powers, Gerry C, Urba, Walter J

“…Escalation of the dose of many antineoplastic drugs is limited by granulocytopenia and thrombocytopenia. Although colony-stimulating factors 1 , 2 and the…”
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Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer by Kantoff, Philip W, Higano, Celestia S, Shore, Neal D, Berger, E. Roy, Small, Eric J, Penson, David F, Redfern, Charles H, Ferrari, Anna C, Dreicer, Robert, Sims, Robert B, Xu, Yi, Frohlich, Mark W, Schellhammer, Paul F

“…The authors report increased survival among patients with advanced hormone-refractory prostate cancer who were vaccinated against a tumor antigen…”
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209 POSTER An open-label, multicenter, phase 1/2 study of AT-101 in combination with docetaxel and prednisone in men with hormone refractory prostate cancer by MacVicar, G, Greco, F.A, Reeves, J, Curti, B, Poiesz, B, Somer, B, Brill, K, Leopold, L

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Phase 1 study of stereotactic body radiotherapy and interleukin-2--tumor and immunological responses by Seung, Steven K, Curti, Brendan D, Crittenden, Marka, Walker, Edwin, Coffey, Todd, Siebert, Janet C, Miller, William, Payne, Roxanne, Glenn, Lyn, Bageac, Alexandru, Urba, Walter J

“…Preclinical models suggest that focal high-dose radiation can make tumors more immunogenic. We performed a pilot study of stereotactic body radiation therapy…”
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Abrogation of the Hematological and Biological Activities of the Interleukin-3/Granulocyte-Macrophage Colony-Stimulating Factor Fusion Protein PIXY321 by Neutralizing Anti-PIXY321 Antibodies in Cancer Patients Receiving High-Dose Carboplatin by Miller, Langdon L., Korn, Edward L., Stevens, Diane S., Janik, John E., Gause, Barry L., Kopp, William C., Holmlund, Jon T., Curti, Brendan D., Sznol, Mario, Smith, John W., Urba, Walter J., Donegan, Sarah E., Watson, Thelma M., Longo, Dan L.

“…This dose-escalation study was performed to evaluate the hematologic activity, biological effects, immunogenicity, and toxicity of PIXY321 (an…”
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