Search Results - "Curry, Jayne E"

A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation by Chan, King Chi, Ting, Choi Man, Chan, Pui Shan, Lo, Ming Chu, Lo, Kwok Wai, Curry, Jayne E, Smyth, Tomoko, Lee, Anne Wing Mui, Ng, Wai Tong, Tsao, George Sai Wah, Wong, Ricky Ngok Shun, Lung, Maria Li, Mak, Nai Ki

“…Nasopharyngeal carcinoma (NPC) is an epithelial malignancy strongly associated with Epstein-Barr virus (EBV). AT13387 is a novel heat shock protein 90 (Hsp90)…”
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The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models by Smyth, Tomoko, Van Looy, Thomas, Curry, Jayne E, Rodriguez-Lopez, Ana M, Wozniak, Agnieszka, Zhu, Meijun, Donsky, Rachel, Morgan, Jennifer G, Mayeda, Mark, Fletcher, Jonathan A, Schöffski, Patrick, Lyons, John, Thompson, Neil T, Wallis, Nicola G

“…The majority of gastrointestinal stromal tumors (GIST) are characterized by activating mutations of KIT, an HSP90 client protein. Further secondary resistance…”
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Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors by Murray, Christopher W, Berdini, Valerio, Buck, Ildiko M, Carr, Maria E, Cleasby, Anne, Coyle, Joseph E, Curry, Jayne E, Day, James E. H, Day, Phillip J, Hearn, Keisha, Iqbal, Aman, Lee, Lydia Y. W, Martins, Vanessa, Mortenson, Paul N, Munck, Joanne M, Page, Lee W, Patel, Sahil, Roomans, Susan, Smith, Kirsten, Tamanini, Emiliano, Saxty, Gordon

“…The DDR1 and DDR2 receptor tyrosine kinases are activated by extracellular collagen and have been implicated in a number of human diseases including cancer. We…”
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AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disorders by Dawson, Mark A., Curry, Jayne E., Barber, Kelly, Beer, Philip A., Graham, Brent, Lyons, John F., Richardson, Caroline J., Scott, Mike A., Smyth, Tomoko, Squires, Matthew S., Thompson, Neil T., Green, Anthony R., Wallis, Nicola G.

“…Summary Constitutive activation of Janus kinase (Jak) 2 is the most prevalent pathogenic event observed in the myeloproliferative disorders (MPD), suggesting…”
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AT9283, a Potent Inhibitor of JAK2, Is Active in JAK2 V617F Myeloproliferative Disease Models by Squires, Matthew S., Curry, Jayne E., Dawson, Mark A., Scott, Mike A., Barber, Kelly, Reule, Matthias, Smyth, Tomoko, Wallis, Nicola, Yule, Murray, Thompson, Neil T., Lyons, John F., Green, Anthony R.

“…AT9283 is a potent inhibitor of JAK2, JAK3, mutant Abl kinase (T315IAbl) and Aurora kinases A and B all of which have an IC50 <5nM. The compound is currently…”
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