Search Results - "Currie, Margaret J."

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response by Kuiper, Caroline, Dachs, Gabi U, Currie, Margaret J, Vissers, Margreet C M

“…Hypoxia-inducible factor (HIF)-1 drives the transcription of hundreds of genes to support cell survival under conditions of microenvironmental and metabolic…”
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Exercise in People With Cancer: A Spotlight on Energy Regulation and Cachexia by Allan, Jessica, Buss, Linda A, Draper, Nick, Currie, Margaret J

“…Exercise is increasingly becoming a standard of cancer care, with well-documented benefits for patients including improved mental wellbeing and reduced…”
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Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice by Buss, Linda A, Ang, Abel D, Hock, Barry, Robinson, Bridget A, Currie, Margaret J, Dachs, Gabi U

“…Preclinical studies have shown a larger inhibition of tumour growth when exercise begins prior to tumour implant (preventative setting) than when training…”
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Effect of immune modulation on the skeletal muscle mitochondrial exercise response: An exploratory study in mice with cancer by Buss, Linda A, Hock, Barry, Merry, Troy L, Ang, Abel D, Robinson, Bridget A, Currie, Margaret J, Dachs, Gabi U

“…Cancer causes mitochondrial alterations in skeletal muscle, which may progress to muscle wasting and, ultimately, to cancer cachexia. Understanding how…”
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Cytomegalovirus and Epstein-Barr virus in breast cancer by Richardson, Ann K, Currie, Margaret J, Robinson, Bridget A, Morrin, Helen, Phung, Yen, Pearson, John F, Anderson, Trevor P, Potter, John D, Walker, Logan C

“…Findings of polymerase chain reaction (PCR) studies of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) and breast cancer vary, making it difficult to…”
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Influence of serum inflammatory cytokines on cytochrome P450 drug metabolising activity during breast cancer chemotherapy: a patient feasibility study by Crake, Rebekah L. I., Strother, Matthew R., Phillips, Elisabeth, Doogue, Matthew P., Zhang, Mei, Frampton, Chris M. A., Robinson, Bridget A., Currie, Margaret J.

“…Individual response to chemotherapy in patients with breast cancer is variable. Obesity and exercise are associated with better and worse outcomes,…”
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Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity by Currie, Margaret J., PhD, Beardsley, Brooke E., MBChB, Harris, Gavin C., FRCPath, Gunningham, Sarah P., PhD, Dachs, Gabi U., PhD, Dijkstra, Birgit, FRACS, Morrin, Helen R., BSc, Wells, J. Elisabeth, PhD, Robinson, Bridget A., MD

“…Summary We performed immunohistochemical analysis of 3 cancer stem cell–related markers (CD44+ /CD24−/low , aldehyde dehydrogenase [ALDH]-1, CD133) in 94…”
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Adipose derived stem cell extracellular vesicles modulate primary human macrophages to an anti‐inflammatory phenotype in vitro by Symonds, Emma K. C., Black, Bianca, Brown, Alexander, Meredith, Ineke, Currie, Margaret J., Hally, Kathryn E., Danielson, Kirsty M.

“…EVs released by adipose derived stem cells (ADSCs) have shown promise as a therapeutic for tissue repair because of their purported immune‐regulatory…”
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Blood Vitamin C Levels of Patients Receiving Immunotherapy and Relationship to Monocyte Subtype and Epigenetic Modification by Topham, Ben, de Vries, Millie, Nonis, Maria, van Berkel, Rebecca, Pullar, Juliet M, Magon, Nicholas J, Vissers, Margreet C M, Currie, Margaret J, Robinson, Bridget A, Gibbs, David, Ang, Abel, Dachs, Gabi U

“…The treatment of metastatic melanoma has been revolutionised by immunotherapy, yet a significant number of patients do not respond, and many experience…”
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Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate by Vissers, Margret C.M., Gunningham, Sarah P., Morrison, Mary J., Dachs, Gabi U., Currie, Margaret J.

“…Control of the transcription factor hypoxia inducible factor (HIF)-1 is mediated by hydroxylation by proline and asparagine hydroxylases. These enzymes require…”
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Quantifying BRCA1 and BRCA2 mRNA Isoform Expression Levels in Single Cells by Lattimore, Vanessa L, Pearson, John F, Morley-Bunker, Arthur E, Spurdle, Amanda B, Robinson, Bridget A, Currie, Margaret J, Walker, Logan C

“…and spliceogenic variants are often associated with an elevated risk of breast and ovarian cancers. Analyses of and splicing patterns have traditionally used…”
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Investigation of Experimental Factors That Underlie BRCA1/2 mRNA Isoform Expression Variation: Recommendations for Utilizing Targeted RNA Sequencing to Evaluate Potential Spliceogenic Variants by Lattimore, Vanessa L, Pearson, John F, Currie, Margaret J, Spurdle, Amanda B, Robinson, Bridget A, Walker, Logan C

“…PCR-based RNA splicing assays are commonly used in diagnostic and research settings to assess the potential effects of variants of uncertain clinical…”
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Gene and Protein Expression Is Altered by Ascorbate Availability in Murine Macrophages Cultured under Tumour-Like Conditions by Ang, Abel D, Vissers, Margreet C M, Burgess, Eleanor R, Currie, Margaret J, Dachs, Gabi U

“…Tumour-associated macrophages (TAMs) are ubiquitously present in tumours and commonly associated with poor prognosis. In immune cells, ascorbate affects…”
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Cancer disparities in indigenous Polynesian populations: Māori, Native Hawaiians, and Pacific people by Dachs, Gabi U, Dr, Currie, Margaret J, PhD, McKenzie, Fiona, PGDipPH, Jeffreys, Mona, PhD, Cox, Brian, PhD, Foliaki, Sunia, PhD, Le Marchand, Loïc, MD, Robinson, Bridget A, MD

“…Summary Polynesia consists of several islands that are scattered across a vast triangle in the Pacific, and include New Zealand, Hawaii, and the Pacific…”
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The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression by Hanrahan, Vickie, Currie, Margaret J, Gunningham, Sarah P, Morrin, Helen R, Scott, Prudence AE, Robinson, Bridget A, Fox, Stephen B

“…Angiogenesis is essential for tumour growth and metastasis. It is controlled by angiogenic factors, one of the most important being vascular endothelial growth…”
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Then and Now: Examining Older People's Engagement in Outdoor Recreation Across the Life Course by Colley, Kathryn, Currie, Margaret J. B., Irvine, Katherine N.

“…Outdoor recreation provides a range of health and wellbeing benefits and facilitates engagement with natural environments. We explore older people's…”
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Neuromodulatory unpaired median neurons in the New Zealand tree weta, Hemideina femorata by Pflüger, Hans-Joachim, Field, Laurence H, Nishino, Hiroshi, Currie, Margaret J

“…The “Graphical abstract” shows a population of large median neuron somata (blue) in a metathoracic ganglion, of which individual cells exhibit features of…”
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Effects of exercise and anti-PD-1 on the tumour microenvironment by Buss, Linda A., Williams, Thomas, Hock, Barry, Ang, Abel D., Robinson, Bridget A., Currie, Margaret J., Dachs, Gabi U.

“…•Exercise reduces the percentage of cytotoxic T cells in melanoma and breast tumours.•The addition of anti-PD-1 reverses this in breast tumours but not…”
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Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies by Hock, Barry D., McKenzie, Judith L., Strother, Matthew, Goddard, Liping, Butt, Leah, Currie, Margaret J.

“…The PD-1-targeting IgG 4 antibody pembrolizumab has significant anti-tumor activity in a proportion of stage IV melanoma patients. A subset of patients develop…”
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Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression by Dachs, Gabi U, Steele, Andrew J, Coralli, Claudia, Kanthou, Chryso, Brooks, Andrew C, Gunningham, Sarah P, Currie, Margaret J, Watson, Ally I, Robinson, Bridget A, Tozer, Gillian M

“…A functional vascular network is essential for the survival, growth and spread of solid tumours, making blood vessels a key target for therapeutic strategies…”
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