Search Results - "Current topics in medicinal chemistry"

Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors by Sabbah, Dima A, Hajjo, Rima, Sweidan, Kamal

“…The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell…”
Get more information

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry by Feng, Minghao, Tang, Bingqing, Liang, Steven H, Jiang, Xuefeng

“…The impact of the development of sulfur therapeutics is instrumental to the evolution of the pharmaceutical industry. Sulfur-derived functional groups can be…”
Get more information

Structure-based virtual screening for drug discovery: principles, applications and recent advances by Lionta, Evanthia, Spyrou, George, Vassilatis, Demetrios K, Cournia, Zoe

“…Structure-based drug discovery (SBDD) is becoming an essential tool in assisting fast and cost-efficient lead discovery and optimization. The application of…”
Get more information

An Unprecedented Revolution in Medicinal Chemistry Driven by the Progress of Biological Science by Chou, Kuo-Chen

“…The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat various diseases and extend human beings' life as long as possible…”
Get more information

Antimicrobial Peptide Structure and Mechanism of Action: A Focus on the Role of Membrane Structure by Lee, Tzong-Hsien, Hall, Kristopher N, Aguilar, Marie-Isabel

“…Antimicrobial peptides (AMPs) are showing increasing promise as potential candidate antibacterial drugs in the face of the rapidly emerging bacterial…”
Get more information

Inhibition of Glycolysis and Glutaminolysis: An Emerging Drug Discovery Approach to Combat Cancer by Akins, Nicholas S, Nielson, Tanner C, Le, Hoang V

“…Cancer cells have a very different metabolism from that of normal cells from which they are derived. Their metabolism is elevated, which allows them to sustain…”
Get more information

Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future by Li, Peng, Snyder, Gretchen L, Vanover, Kimberly E

“…Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting approximately 1% of the world's population. This disease is associated with…”
Get more information

Antimicrobial Peptides Under Clinical Trials by Greber, Katarzyna E, Dawgul, Małgorzata

“…Today microbial drug resistance has become a serious problem not only within inpatient setting but also within outpatient setting. Repeated intake and…”
Get more information

Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications by Anderson, George, Maes, Michael

“…The gut and mitochondria have emerged as two important hubs at the cutting edge of research across a diverse array of medical conditions, including most…”
Get more information

Trifluoromethyl ethers and -thioethers as tools for medicinal chemistry and drug discovery by Landelle, Gregory, Panossian, Armen, Leroux, Frederic R

“…The ever-growing number of fluorinated compounds in medicinal and agrochemical applications has led to a remarkable positive emulation in research. The last…”
Get more information

Non-Membrane Permeabilizing Modes of Action of Antimicrobial Peptides on Bacteria by Scocchi, Marco, Mardirossian, Mario, Runti, Giulia, Benincasa, Monica

“…Antimicrobial peptides (AMPs) are a large class of innate immunity effectors with a remarkable capacity to inactivate microorganisms. Their ability to kill…”
Get more information

Applications and toxicity of silver nanoparticles: a recent review by Marin, Stefania, Vlasceanu, George Mihail, Tiplea, Roxana Elena, Bucur, Ioana Raluca, Lemnaru, Madalina, Marin, Maria Minodora, Grumezescu, Alexandru Mihai

“…Silver nanoparticles (AgNPs) exhibit a consistent amount of flexible properties which endorse them for a larger spectrum of applications in biomedicine and…”
Get more information

Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In Vitro by Ivask, Angela, Titma, Tiina, Visnapuu, Meeri, Vija, Heiki, Kakinen, Aleksandr, Sihtmae, Mariliis, Pokhrel, Suman, Madler, Lutz, Heinlaan, Margit, Kisand, Vambola, Shimmo, Ruth, Kahru, Anne

“…The knowledge on potential harmful effects of metallic nanomaterials lags behind their increased use in consumer products and therefore, the safety data on…”
Get more information

Chalcone Derivatives: Anti-inflammatory Potential and Molecular Targets Perspectives by Mahapatra, Debarshi Kar, Bharti, Sanjay Kumar, Asati, Vivek

“…Chalcone or (E)-1,3-diphenyl-2-propene-1-one scaffold has gained considerable scientific interest in medicinal chemistry owing to its simple chemistry, ease in…”
Get more information

A Practical Guide to Molecular Docking and Homology Modelling for Medicinal Chemists by Lohning, Anna E, Levonis, Stephan M, Williams-Noonan, Billy, Schweiker, Stephanie S

“…Elucidating details of the relationship between molecular structure and a particular biological end point is essential for successful, rational drug discovery…”
Get more information

Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing Agents by Tangutur, Anjana Devi, Kumar, Dinesh, Krishna, Kommalapati Vamsi, Kantevari, Srinivas

“…Microtubules form crucial dynamic structural cellular components of the cell and are composed of the alpha beta tubulin heterodimers. Microtubules are involved…”
Get more information

Akt Pathway Inhibitors by Uko, Nne E, Güner, Osman F, Matesic, Diane F, Bowen, J Phillip

“…Cancer is a devastating disease that has plagued humans from ancient times to this day. After decades of slow research progress, promising drug development,…”
Get more information

SCAP/SREBPs are Central Players in Lipid Metabolism and Novel Metabolic Targets in Cancer Therapy by Cheng, Xiang, Li, Jianying, Guo, Deliang

“…Lipid metabolism reprogramming emerges as a new hallmark of malignancies. Sterol regulatory element-binding proteins (SREBPs), which are central players in…”
Get more information

Recent Progress in 1H-1,2,3-triazoles as Potential Antifungal Agents by Poonia, Nisha, Kumar, Aman, Kumar, Vijay, Yadav, Monika, Lal, Kashmiri

“…The need to overcome ever-increasing cases of antifungal resistance and circumvent side effects and drug interactions related to currently available drugs has…”
Get more information

Mechanisms and Characteristics of Sulfonylureas and Glinides by Lv, Wei, Wang, Xianqing, Xu, Qian, Lu, Wencong

“…Type 2 diabetes mellitus is a complex progressive endocrine disease characterized by hyperglycemia and life-threatening complications. It is the most common…”
Get more information