Search Results - "Current research in translational medicine"

The role of myofibroblasts in wound healing by Hinz, B.

“…The importance of proper skin wound healing becomes evident when our body's repair mechanisms fail, leading to either non-healing (chronic) wounds or excessive…”
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Characteristics and clinical applications of Wharton’s jelly-derived mesenchymal stromal cells by Liau, L.L., Ruszymah, B.H.I., Ng, M.H., Law, J.X.

“…Mesenchymal stromal cells (MSCs) are widely used in the clinic because they involve fewer ethical issues and safety concerns compared to other stem cells such…”
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Insights into cytokine release syndrome and neurotoxicity after CD19-specific CAR-T cell therapy by Gauthier, Jordan, Turtle, Cameron J.

“…T-cells engineered to express CD19-specific chimeric antigen receptors (CD19 CAR-T cells) can achieve high response rates in patients with refractory/relapsed…”
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Anti-oxidant, antibacterial, anti-biofilm, and anti-quorum sensing activities of four essential oils against multidrug-resistant bacterial clinical isolates by Alibi, Sana, Ben Selma, Walid, Ramos-Vivas, José, Smach, Mohamed Ali, Touati, Ridha, Boukadida, Jalel, Navas, Jésus, Ben Mansour, Hedi

“…Outbreaks of multidrug-resistant bacteria are increasingly reported at the clinical setting. The antimicrobial, anti-biofilm, anti-quorum sensing, and…”
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Machine learning and artificial intelligence in the service of medicine: Necessity or potentiality? by Alsuliman, Tamim, Humaidan, Dania, Sliman, Layth

“…As a result of the worldwide health care system digitalization trend, the produced healthcare data is estimated to reach as much as 2314 Exabytes of new data…”
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Thoughts on cartilage tissue engineering: A 21st century perspective by Stampoultzis, Theofanis, Karami, Peyman, Pioletti, Dominique P.

“…In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus even minor defects could result in progressive degeneration,…”
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A common TMPRSS2 variant has a protective effect against severe COVID-19 by David, Alessia, Parkinson, Nicholas, Peacock, Thomas P, Pairo-Castineira, Erola, Khanna, Tarun, Cobat, Aurelie, Tenesa, Albert, Sancho-Shimizu, Vanessa, Casanova, Jean-Laurent, Abel, Laurent, Barclay, Wendy S., Baillie, J.Kenneth, Sternberg, Michael JE

“…The human protein transmembrane protease serine type 2 (TMPRSS2) plays a key role in SARS-CoV-2 infection, as it is required to activate the virus’ spike…”
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Chimeric antigen-receptor T-cell therapy for hematological malignancies and solid tumors: Clinical data to date, current limitations and perspectives by Gauthier, J., Yakoub-Agha, I.

“…Progress in our understanding of basic immunology along with the advent of bioengineering technologies have made possible the production of human T-cells…”
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Role of Nrf2 in rheumatoid arthritis by Chadha, Swati, Behl, Tapan, Kumar, Arun, Khullar, Gaurav, Arora, Sandeep

“…Rheumatoid arthritis comprises the roots of 19th century and is an autoimmune and chronic inflammatory disorder leading to progressive joint destruction. This…”
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Age and vitamin D affect the magnitude of the antibody response to the first dose of the SARS-CoV-2 BNT162b2 vaccine by Piec, Isabelle, Cook, Laura, Dervisevic, Samir, Fraser, William D, Ruetten, Scott, Berman, Marvin, English, Emma, John, W Garry

“…•Evidence before this study Immunization is the most important strategy to facilitate the end of the global pandemic. Vaccines, authorized for use globally,…”
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Mechanistic insights into the role of pyroptosis in rheumatoid arthritis by Chadha, Swati, Behl, Tapan, Bungau, Simona, Kumar, Arun, Arora, Rashmi, Gupta, Amit, Uddin, Md Sahab, Zengin, Gokhan, Aleya, Lotfi, Setia, Dhruv, Arora, Sandeep

“…Cell death is ascribed as an essential biological process that is fundamental for the development of an organism along with its survival. The procedure…”
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CAR T-cell treatment during the COVID-19 pandemic: Management strategies and challenges by Hu, Yongxian, Tan Su Yin, Elaine, Yang, Yingying, Wu, Hengwei, Wei, Guoqing, Su, Junwei, Cui, Qu, Jin, Aiyun, Yang, Li, Fu, Shan, Zhou, Jianfeng, Qiu, Lugui, Zhang, Xi, Liang, Aibin, Jing, Hongmei, Li, Yuhua, Blaise, Didier, Mohty, Mohamad, Nagler, Arnon, Huang, He

“…The pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly…”
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Advances in adoptive T-cell therapy for metastatic melanoma by Das, Aparimita, Ghose, Aruni, Naicker, Kevin, Sanchez, Elisabet, Chargari, Cyrus, Rassy, Elie, Boussios, Stergios

“…Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour…”
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Update of inflammatory proliferative retinopathy: Ischemia, hypoxia and angiogenesis by Aouiss, A., Anka Idrissi, D., Kabine, M., Zaid, Y.

“…Diabetic retinopathy (DR) and retinopathy of prematurity (ROP) present two examples of proliferative retinopathy, characterized by the same stages of…”
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New scenarios in Vacuoles, E1 enzyme, X linked, Autoinflammatory, Somatic (VEXAS) syndrome: Evolution from myelodysplastic syndrome to acute myeloid leukemia by Battipaglia, Giorgia, Vincenzi, Annamaria, Falconi, Giulia, Fiore, Alessia, D'Agostino, Francesco, Iannotta, Raffaella, Grimaldi, Francesco, Gurnari, Carmelo, Galossi, Elisa, Crisà, Elena, Bonello, Francesca, Scalia, Giulia, Izzo, Barbara, Voso, Maria Teresa, Pane, Fabrizio

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Pluronic F127 composite hydrogel for the repair of contraction suppressed full-thickness skin wounds in a rabbit model by Sharun, Khan, Banu, S. Amitha, Mamachan, Merlin, Subash, Athira, Karikalan, Mathesh, Vinodhkumar, Obli Rajendran, Manjusha, K.M., Kumar, Rohit, Telang, A.G., Dhama, Kuldeep, Pawde, A.M., Maiti, Swapan Kumar, Amarpal

“…•The findings indicate that the wound healing potential of AdSVF, AdMSC, and AdMSC-CM was enhanced when loaded in PF127 hydrogel and applied topically.•Even…”
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Genetic variants of dectin-1 and their antifungal immunity impact in hematologic malignancies: A comprehensive systematic review by Aghaei, Mojtaba, Khademi, Reyhane, Far, Mohammad Ali Jalali, Bahreiny, Seyed Sobhan, Mahdizade, Amir Hossein, Amirrajab, Nasrin

“…Fungal infections pose a significant threat to individuals with hematologic malignancies due to compromised immune systems. Dectin-1, a pivotal pattern…”
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Scaling up human mesenchymal stem cell manufacturing using bioreactors for clinical uses by Jankovic, Marina Gazdic, Stojkovic, Miodrag, Bojic, Sanja, Jovicic, Nemanja, Kovacevic, Marina Miletic, Ivosevic, Zeljko, Juskovic, Aleksandar, Kovacevic, Vojin, Ljujic, Biljana

“…•Human mesenchymal stem cells (hMSCs) are the most promising pharmaceutical multipotent stem cells.•Despite the vast potential, the hMSCs therapeutic use is…”
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Evaluation and management of hepatic dysfunction, portal hypertension and portal/splanchnic vein thrombosis in patients with myelofibrosis undergoing allogeneic haematopoietic cell transplantation: A practice based survey on behalf of the Chronic Malignancies Working Party of the EBMT by Battipaglia, Giorgia, Polverelli, Nicola, Tuffnell, Joe, Chiusolo, Patrizia, Robin, Marie, Gambella, Massimiliano, Broers, Annoek, Sala, Elisa, Passweg, Jakob, Furst, Sabine, Friis, Lone Smidtrup, Dulery, Remy, de Witte, Moniek, Srour, Micha, Finazzi, Maria Chiara, Wehr, Claudia, Nagler, Arnon, Richardson, Deborah, Bethge, Wolfgang, Clark, Andrew, Drozd-Sokolowska, Joanna, Raj, Kavita, Czerw, Tomasz, Hernández-Boluda, Juan Carlos, McLornan, Donal P.

“…Heterogeneous approaches exist in regard to the management of disease-related co-morbidities in potential allogeneic haematopoietic cell transplantation…”
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In silico analysis and structural vaccinology prediction of Toxoplasma gondii ROP41 gene via immunoinformatics methods as a vaccine candidate by Asadi, Masoumeh, Ghaffari, Ali Dalir, Mohammadhasani, Fatemeh

“…Toxoplasma gondii (T. gondii) infects all warm-blooded animals, including humans. Currently, no effective treatments exist to prevent the generation of chronic…”
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