Search Results - "Current opinion in virology"

Transmission routes of respiratory viruses among humans by Kutter, Jasmin S, Spronken, Monique I, Fraaij, Pieter L, Fouchier, Ron AM, Herfst, Sander

“…•Respiratory viruses are transmitted via contact, droplets or aerosols.•Most studies on inter-human transmission routes are inconclusive.•The relative…”
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Emerging and re-emerging coronaviruses in pigs by Wang, Qiuhong, Vlasova, Anastasia N, Kenney, Scott P, Saif, Linda J

“…[Display omitted] •Three coronaviruses are emerging/reemerging in pigs.•The three porcine coronaviruses may have originated from other species.•The clinical…”
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Structure of SARS-CoV-2 spike protein by Zhang, Jun, Xiao, Tianshu, Cai, Yongfei, Chen, Bing

“…The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in…”
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Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19 by Painter, George R, Natchus, Michael G, Cohen, Oren, Holman, Wendy, Painter, Wendy P

“…•Molnupiravir is a broad acting, oral antiviral versus SARS-CoV-2, flu, Ebola and others.•Clinical development was greatly accelerated in response to the…”
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Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection by Vandyck, Koen, Deval, Jerome

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic. The coronavirus 3-chymotrypsin-like protease (3CLpro)…”
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Nucleoside analogues for the treatment of coronavirus infections by Pruijssers, Andrea J, Denison, Mark R

“…•Coronaviruses (CoV) represent current and future risk for pandemic zoonotic infections.•Nucleoside analogues are highly active across multiple virus…”
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In vivo tissue-tropism of adeno-associated viral vectors by Srivastava, Arun

“…•AAV is a non-pathogenic virus, and recombinant AAV vectors have proven to be highly efficient for gene delivery to a wide variety of cell types, tissue, and…”
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Current status and prospects of HIV treatment by Cihlar, Tomas, Fordyce, Marshall

“…•With no available cure, treatment of HIV infection requires life-long therapy.•A combination of three drugs is the current standard for chronic HIV…”
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Immune history and influenza virus susceptibility by Cobey, Sarah, Hensley, Scott E

“…•Early viral infections shape B cell response recalled against future viral strains.•Competition between memory and naïve B cells occurs in secondary viral…”
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Interferon-stimulated genes and their antiviral effector functions by Schoggins, John W, Rice, Charles M

“…► IFN induces a diverse range of antiviral effectors. ► Each virus has a unique, but partially overlapping, antiviral ‘ISG profile’. ► IFN effectors target…”
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Baloxavir marboxil: the new influenza drug on the market by O’Hanlon, Ryan, Shaw, Megan L

“…•Approval of first endonuclease inhibitor for influenza treatment.•Represents a new class of influenza drug.•Single dose is clinically effective. For the first…”
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Emerging viruses in aquaculture by Kibenge, Frederick SB

“…[Display omitted] •There is a continuous emergence of viral diseases in aquaculture.•Emergence of viral diseases in aquaculture may be driven by virus, animal…”
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Engineering virus-like particles as vaccine platforms by Frietze, Kathryn M, Peabody, David S, Chackerian, Bryce

“…•VLP have been engineered to improve their utility as vaccine platforms.•Targeted engineering of VLPs has enhanced immunogenicity, stability, and…”
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Future considerations for the mRNA-lipid nanoparticle vaccine platform by Igyártó, Botond Z, Jacobsen, Sonya, Ndeupen, Sonia

“…Vaccines based on mRNA-containing lipid nanoparticles (LNPs) pioneered by Katalin Karikó and Drew Weissman at the University of Pennsylvania are a promising…”
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Thrips transmission of tospoviruses by Rotenberg, Dorith, Jacobson, Alana L, Schneweis, Derek J, Whitfield, Anna E

“…•Research is revealing greater genetic diversity of thrips vectors and tospoviruses.•Specific thrips–tospovirus population interactions underlie transmission…”
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Viral diseases of the central nervous system by Swanson, Phillip A, McGavern, Dorian B

“…•A diverse spectrum of viruses can enter the CNS, causing acute and chronic neurological disorders.•Virus-induced CNS diseases are influenced by routes of…”
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Recent advances in antiviral drug development towards dengue virus by Troost, Berit, Smit, Jolanda M

“…•Evaluating drug efficacy, specificity and toxicity may help to develop an optimal treatment regime for in vivo studies.•Measuring time to resolve viremia in…”
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Zoonotic disease and virome diversity in bats by Van Brussel, Kate, Holmes, Edward C

“…The emergence of zoonotic viral diseases in humans commonly reflects exposure to mammalian wildlife. Bats (order Chiroptera) are arguably the most important…”
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Global overview and major challenges of host prediction methods for uncultivated phages by Coclet, Clément, Roux, Simon

“…•Global phage diversity is now primarily explored through cultivation-independent metagenomics.•Metagenome-derived phages are typically linked to their host(s)…”
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Virus recognition of glycan receptors by Thompson, Andrew J, de Vries, Robert P, Paulson, James C

“…[Display omitted] •Most mammalian virus families use cell-surface glycans as receptors.•Glycan receptors are diverse in structure and distribution, giving rise…”
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