Search Results - "Current opinion in pharmacology"

The role of gut microbiota in obesity, diabetes mellitus, and effect of metformin: new insights into old diseases by Pascale, Alessia, Marchesi, Nicoletta, Govoni, Stefano, Coppola, Adriana, Gazzaruso, Carmine

“…There is a recent growing evidence that abnormalities in the microbiota composition can have a major role in the development of obesity and diabetes and that…”
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Flavonoids in hypertension: a brief review of the underlying mechanisms by Maaliki, Dina, Shaito, Abdullah A, Pintus, Gianfranco, El-Yazbi, Ahmed, Eid, Ali H

“…Different pathways implicated in the effects of flavonoids on blood pressure regulation. [Display omitted] •Increased flavonoid consumption imparts…”
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PD-1/PD-L1 inhibitors by Sunshine, Joel, Taube, Janis M

“…Highlights • Remarkable and durable anti-tumor activity with several anti-PD-1/PD-L1 antibodies. • FDA approval for anti-PD-1 antibodies for advanced melanoma…”
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Update on the antibiotic resistance crisis by Rossolini, Gian Maria, Arena, Fabio, Pecile, Patrizia, Pollini, Simona

“…Highlights • The antibiotic resistance crisis is jeopardizing feasibility of medical practices. • The antibiotic resistance crisis is more serious with…”
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Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis by Gheorghe, Cassandra Elise, Martin, Jason A, Manriquez, Francisca Villalobos, Dinan, Timothy G, Cryan, John F, Clarke, Gerard

“…[Display omitted] The gut-brain axis is a bidirectional communication system between the central nervous system and the gastrointestinal tract, in which…”
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Cancer cell and macrophage cross-talk in the tumor microenvironment by Dehne, Nathalie, Mora, Javier, Namgaladze, Dmitry, Weigert, Andreas, Brüne, Bernhard

“…•The tumor microenvironment contains innate immune cells, for example, macrophages.•Hypoxia imposes stress to tumor cells and their environment.•Tumor cell…”
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Parathyroid hormone: anabolic and catabolic actions on the skeleton by Silva, Barbara C, Bilezikian, John P

“…Highlights • Parathyroid hormone has dual anabolic and catabolic actions on the skeleton. • The OPG–RANKL–RANK pathway is the main mediator of the catabolic…”
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Muscle as a paracrine and endocrine organ by Giudice, Jimena, Taylor, Joan M

“…Highlights • Skeletal muscle secretes myokines that exert autocrine paracrine and endocrine effects. • Paracrine factors modulate muscle angiogenesis,…”
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Obesity and cancer: inflammation bridges the two by Kolb, Ryan, Sutterwala, Fayyaz S, Zhang, Weizhou

“…Highlights • Obesity is associated with chronic inflammation and chronic diseases. • Obesity is associated with increased risk and progression of several…”
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Adipose tissue inflammation in obesity: a metabolic or immune response? by Stolarczyk, Emilie

“…•Immunometabolism of the adipose tissue affects insulin resistance and obesity.•Type 2 immune response protects against diet-induced obesity.•Cytokines…”
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Targeting CD73 to augment cancer immunotherapy by Roh, Meejeon, Wainwright, Derek A, Wu, Jennifer D, Wan, Yong, Zhang, Bin

“…•CD73 is a multifunctional ectoenzyme affecting both tumor cells and immune cells.•CD73 has been hijacked by TME to promote tumor growth and…”
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Immunosuppressive activities of adenosine in cancer by Allard, Bertrand, Beavis, Paul A, Darcy, Phillip K, Stagg, John

“…Highlights • Adenosine protects tissues against excessive inflammation and promotes tissue repair. • The adenosine pathway is hijacked to dampen anti-tumor…”
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The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases by Andreadi, Aikaterini, Bellia, Alfonso, Di Daniele, Nicola, Meloni, Marco, Lauro, Renato, Della-Morte, David, Lauro, Davide

“…Type 2 Diabetes Mellitus (T2D) is a chronic disease with a pandemic incidence whose pathogenesis has not yet been clarified. Raising evidence highlighted the…”
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Targeting the renin–angiotensin system as novel therapeutic strategy for pulmonary diseases by Tan, Wan Shun Daniel, Liao, Wupeng, Zhou, Shuo, Mei, Dan, Wong, Wai-Shiu Fred

“…•Renin angiotensin system (RAS) is believed to play a major role in regulating electrolyte balance and blood pressure.•Recent studies have implicated RAS…”
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Drug-resistant tuberculosis: challenges and opportunities for diagnosis and treatment by Koch, Anastasia, Cox, Helen, Mizrahi, Valerie

“…[Display omitted] •Management of tuberculosis is complicated by high levels of drug resistance in some regions of the world.•Increasingly, molecular…”
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PI3K inhibitors in inflammation, autoimmunity and cancer by Stark, Anne-Katrien, Sriskantharajah, Srividya, Hessel, Edith M, Okkenhaug, Klaus

“…Highlights • Preclinical studies support us of PI3K inhibitors in autoimmunity and inflammation. • First in class PI3K inhibitor has been approved for…”
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YAP/TAZ as therapeutic targets in cancer by Zanconato, Francesca, Battilana, Giusy, Cordenonsi, Michelangelo, Piccolo, Stefano

“…Highlights • YAP/TAZ are activated in a broad number of solid tumors. • YAP/TAZ instrumental for tumor initiation, growth, metastasis and chemoresistance. •…”
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Stem cell-based therapeutic strategies for cartilage defects and osteoarthritis by De Bari, Cosimo, Roelofs, Anke J

“…•ACI is the gold standard cell therapy for cartilage defect repair.•MSCs are promising substitutes for chondrocytes in ACI-like procedures.•Intra-articular MSC…”
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Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus by Kane, John P., Pullinger, Clive R., Goldfine, Ira D., Malloy, Mary J.

“…Diabetes mellitus is a complex disease. We are increasingly gaining a better understanding of its mechanisms at the molecular level. From these new insights,…”
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Cachexia and sarcopenia: mechanisms and potential targets for intervention by Argilés, Josep M, Busquets, Silvia, Stemmler, Britta, López-Soriano, Francisco J

“…Highlights • Cachexia and sarcopenia share common trends: altered protein synthesis and degradation. • Cachexia and sarcopenia are both driven by inflammation…”
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