Search Results - "Current opinion in chemical biology"

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  1. 1

    The roles of microRNAs in epigenetic regulation by Yao, Qian, Chen, Yuqi, Zhou, Xiang

    Published in Current opinion in chemical biology (01-08-2019)
    “…MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18–25 nucleotides in length, now recognized as one of the major regulatory gene families in…”
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  2. 2

    Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology? by McFarland, Sherri A., Mandel, Arkady, Dumoulin-White, Roger, Gasser, Gilles

    Published in Current opinion in chemical biology (01-06-2020)
    “…Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities…”
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  3. 3

    Cyclic peptide therapeutics: past, present and future by Zorzi, Alessandro, Deyle, Kaycie, Heinis, Christian

    Published in Current opinion in chemical biology (01-06-2017)
    “…•On average, one cyclic peptide drug is approved every year.•New strategies based on rational design and in vitro evolution deliver peptides to new…”
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  4. 4

    Machine learning in protein structure prediction by AlQuraishi, Mohammed

    Published in Current opinion in chemical biology (01-12-2021)
    “…Prediction of protein structure from sequence has been intensely studied for many decades, owing to the problem's importance and its uniquely well-defined…”
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  5. 5

    Fundamentals of ion mobility spectrometry by Gabelica, Valérie, Marklund, Erik

    Published in Current opinion in chemical biology (01-02-2018)
    “…•CCS distributions and shifts contain valuable information about analytes.•Compound-dependent effects of gas, field and temperature explain calibration…”
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  6. 6

    Protein sequence design with deep generative models by Wu, Zachary, Johnston, Kadina E., Arnold, Frances H., Yang, Kevin K.

    Published in Current opinion in chemical biology (01-12-2021)
    “…Protein engineering seeks to identify protein sequences with optimized properties. When guided by machine learning, protein sequence generation methods can…”
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  7. 7

    Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles by Gingras, Anne-Claude, Abe, Kento T, Raught, Brian

    Published in Current opinion in chemical biology (01-02-2019)
    “…The use of proximity-dependent biotinylation approaches combined with mass spectrometry (e.g. BioID and APEX) has revolutionized the study of protein–protein…”
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  8. 8

    Lignocellulose degradation mechanisms across the Tree of Life by Cragg, Simon M, Beckham, Gregg T, Bruce, Neil C, Bugg, Timothy DH, Distel, Daniel L, Dupree, Paul, Etxabe, Amaia Green, Goodell, Barry S, Jellison, Jody, McGeehan, John E, McQueen-Mason, Simon J, Schnorr, Kirk, Walton, Paul H, Watts, Joy EM, Zimmer, Martin

    Published in Current opinion in chemical biology (01-12-2015)
    “…•Biological lignocellulose deconstruction mechanisms are diverse.•They are widely but sparsely dispersed across the Tree of Life.•Some mechanisms operate at…”
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  9. 9

    Host defense antimicrobial peptides as antibiotics: design and application strategies by Mishra, Biswajit, Reiling, Scott, Zarena, D, Wang, Guangshun

    Published in Current opinion in chemical biology (01-06-2017)
    “…•Antibiotic resistance is a serious problem of our era.•Antimicrobial peptides are important templates for developing new antibiotics.•Both peptide discovery…”
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  10. 10

    Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area by Ran, Xu, Gestwicki, Jason E

    Published in Current opinion in chemical biology (01-06-2018)
    “…Protein–protein interactions (PPI) were once considered ‘undruggable’, but clinical successes, driven by advanced methods in drug discovery, have challenged…”
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  11. 11

    Insights into the physiology of ammonia-oxidizing microorganisms by Stein, Lisa Y

    Published in Current opinion in chemical biology (01-04-2019)
    “…Nitrification is the aerobic process of the nitrogen cycle that converts ammonia to nitrate and is facilitated by ammonia-oxidizing and nitrite-oxidizing…”
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  12. 12

    Combinatorial chemistry in drug discovery by Liu, Ruiwu, Li, Xiaocen, Lam, Kit S

    Published in Current opinion in chemical biology (01-06-2017)
    “…Several combinatorial methods have been developed to create focused or diverse chemical libraries with a wide range of linear or macrocyclic chemical…”
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  13. 13

    Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics by Saarbach, Jacques, Sabale, Pramod M, Winssinger, Nicolas

    Published in Current opinion in chemical biology (01-10-2019)
    “…[Display omitted] Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability…”
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  14. 14

    Single-cell protein analysis by mass spectrometry by Slavov, Nikolai

    Published in Current opinion in chemical biology (01-02-2021)
    “…Human physiology and pathology arise from the coordinated interactions of diverse single cells. However, analyzing single cells has been limited by the low…”
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  15. 15

    Protein immobilization technology for flow biocatalysis by Romero-Fernández, María, Paradisi, Francesca

    Published in Current opinion in chemical biology (01-04-2020)
    “…Enzymatic immobilization has been at the forefront of applied biocatalysis as it enables convenient isolation and reuse of the catalyst if the target reaction…”
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  16. 16

    Collision induced unfolding of isolated proteins in the gas phase: past, present, and future by Dixit, Sugyan M, Polasky, Daniel A, Ruotolo, Brandon T

    Published in Current opinion in chemical biology (01-02-2018)
    “…•Collision induced unfolding (CIU) uses gas phase activation to probe biomolecules.•CIU can detect subtle changes in protein structure, stability or…”
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  17. 17

    How close are we to complete annotation of metabolomes? by Viant, Mark R, Kurland, Irwin J, Jones, Martin R, Dunn, Warwick B

    Published in Current opinion in chemical biology (01-02-2017)
    “…•No exhaustive experimental characterisation of an organism’s metabolome reported.•Deep metabolome annotation strategies based on multi-platform…”
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  18. 18

    Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics by Kaur, Arshpreet, Baldwin, Jeremy, Brar, Deshkanwar, Salunke, Deepak B., Petrovsky, Nikolai

    Published in Current opinion in chemical biology (01-10-2022)
    “…Until recently, the development of new human adjuvants was held back by a poor understanding of their mechanisms of action. The field was revolutionized by the…”
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  19. 19

    Recent advances of thiol-selective bioconjugation reactions by Ochtrop, Philipp, Hackenberger, Christian Peter Richard

    Published in Current opinion in chemical biology (01-10-2020)
    “…Proteins are the most abundant biomolecules within a cell and are involved in all biochemical cellular processes, fulfilling specific functions with unmatched…”
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  20. 20

    Metal-based anticancer chemotherapeutic agents by Muhammad, Nafees, Guo, Zijian

    Published in Current opinion in chemical biology (01-04-2014)
    “…•Rational design of PtIV prodrugs to reduce toxicity and resistance of clinical PtII drugs.•Conjugation of targeting or imaging agents to PtIV…”
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