Search Results - "Current opinion in chemical biology"
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The roles of microRNAs in epigenetic regulation
Published in Current opinion in chemical biology (01-08-2019)“…MicroRNAs (miRNAs) are small noncoding RNAs, approximately 18–25 nucleotides in length, now recognized as one of the major regulatory gene families in…”
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Metal-based photosensitizers for photodynamic therapy: the future of multimodal oncology?
Published in Current opinion in chemical biology (01-06-2020)“…Photodynamic therapy (PDT) is an approved medical technique to treat certain forms of cancer. It has been used to complement traditional anticancer modalities…”
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Cyclic peptide therapeutics: past, present and future
Published in Current opinion in chemical biology (01-06-2017)“…•On average, one cyclic peptide drug is approved every year.•New strategies based on rational design and in vitro evolution deliver peptides to new…”
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Machine learning in protein structure prediction
Published in Current opinion in chemical biology (01-12-2021)“…Prediction of protein structure from sequence has been intensely studied for many decades, owing to the problem's importance and its uniquely well-defined…”
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Fundamentals of ion mobility spectrometry
Published in Current opinion in chemical biology (01-02-2018)“…•CCS distributions and shifts contain valuable information about analytes.•Compound-dependent effects of gas, field and temperature explain calibration…”
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Protein sequence design with deep generative models
Published in Current opinion in chemical biology (01-12-2021)“…Protein engineering seeks to identify protein sequences with optimized properties. When guided by machine learning, protein sequence generation methods can…”
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Getting to know the neighborhood: using proximity-dependent biotinylation to characterize protein complexes and map organelles
Published in Current opinion in chemical biology (01-02-2019)“…The use of proximity-dependent biotinylation approaches combined with mass spectrometry (e.g. BioID and APEX) has revolutionized the study of protein–protein…”
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Lignocellulose degradation mechanisms across the Tree of Life
Published in Current opinion in chemical biology (01-12-2015)“…•Biological lignocellulose deconstruction mechanisms are diverse.•They are widely but sparsely dispersed across the Tree of Life.•Some mechanisms operate at…”
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Host defense antimicrobial peptides as antibiotics: design and application strategies
Published in Current opinion in chemical biology (01-06-2017)“…•Antibiotic resistance is a serious problem of our era.•Antimicrobial peptides are important templates for developing new antibiotics.•Both peptide discovery…”
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Inhibitors of protein–protein interactions (PPIs): an analysis of scaffold choices and buried surface area
Published in Current opinion in chemical biology (01-06-2018)“…Protein–protein interactions (PPI) were once considered ‘undruggable’, but clinical successes, driven by advanced methods in drug discovery, have challenged…”
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Insights into the physiology of ammonia-oxidizing microorganisms
Published in Current opinion in chemical biology (01-04-2019)“…Nitrification is the aerobic process of the nitrogen cycle that converts ammonia to nitrate and is facilitated by ammonia-oxidizing and nitrite-oxidizing…”
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Combinatorial chemistry in drug discovery
Published in Current opinion in chemical biology (01-06-2017)“…Several combinatorial methods have been developed to create focused or diverse chemical libraries with a wide range of linear or macrocyclic chemical…”
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Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics
Published in Current opinion in chemical biology (01-10-2019)“…[Display omitted] Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide mimetics. Salient features include the stability…”
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Single-cell protein analysis by mass spectrometry
Published in Current opinion in chemical biology (01-02-2021)“…Human physiology and pathology arise from the coordinated interactions of diverse single cells. However, analyzing single cells has been limited by the low…”
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Protein immobilization technology for flow biocatalysis
Published in Current opinion in chemical biology (01-04-2020)“…Enzymatic immobilization has been at the forefront of applied biocatalysis as it enables convenient isolation and reuse of the catalyst if the target reaction…”
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Collision induced unfolding of isolated proteins in the gas phase: past, present, and future
Published in Current opinion in chemical biology (01-02-2018)“…•Collision induced unfolding (CIU) uses gas phase activation to probe biomolecules.•CIU can detect subtle changes in protein structure, stability or…”
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How close are we to complete annotation of metabolomes?
Published in Current opinion in chemical biology (01-02-2017)“…•No exhaustive experimental characterisation of an organism’s metabolome reported.•Deep metabolome annotation strategies based on multi-platform…”
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Toll-like receptor (TLR) agonists as a driving force behind next-generation vaccine adjuvants and cancer therapeutics
Published in Current opinion in chemical biology (01-10-2022)“…Until recently, the development of new human adjuvants was held back by a poor understanding of their mechanisms of action. The field was revolutionized by the…”
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Recent advances of thiol-selective bioconjugation reactions
Published in Current opinion in chemical biology (01-10-2020)“…Proteins are the most abundant biomolecules within a cell and are involved in all biochemical cellular processes, fulfilling specific functions with unmatched…”
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Metal-based anticancer chemotherapeutic agents
Published in Current opinion in chemical biology (01-04-2014)“…•Rational design of PtIV prodrugs to reduce toxicity and resistance of clinical PtII drugs.•Conjugation of targeting or imaging agents to PtIV…”
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