Search Results - "Current medicinal chemistry"

Recent Research on Flavonoids and their Biomedical Applications by Wen, Kangmei, Fang, Xiaochuan, Yang, Junli, Yao, Yongfang, Nandakumar, Kutty Selva, Salem, Mohamed Labib, Cheng, Kui

“…Flavonoids, commonly found in various plants, are a class of polyphenolic compounds having a basic structural unit of 2-phenylchromone. Flavonoid compounds…”
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Glioblastoma Multiforme, Diagnosis and Treatment; Recent Literature Review by Batash, Ron, Asna, Noam, Schaffer, Pamela, Francis, Nicole, Schaffer, Moshe

“…Glioblastoma multiforme (GBM) is the most common malignant primary brain tumor, with an incidence of 3.19 cases per 100,000 person years and remarkably poor…”
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Metal-Organic Framework (MOF)-Based Drug Delivery by Cao, Jian, Li, Xuejiao, Tian, Hongqi

“…Developing a controllable drug delivery system is imperative and important to reduce side effects and enhance the therapeutic efficacy of drugs. Metal-organic…”
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Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development by Li, Hanxuan, Xiao, Zhousheng, Quarles, L Darryl, Li, Wei

“…CDATA[Osteoporosis is a pathological loss of bone mass due to an imbalance in bone remodeling where osteoclast-mediated bone resorption exceeds…”
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Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy by Zhou, Weiqiang, Guo, Shanchun, Liu, Mingli, Burow, Matthew E, Wang, Guangdi

“…Chemokines, which have chemotactic abilities, are comprised of a family of small cytokines with 8-10 kilodaltons. Chemokines work in immune cells by…”
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Antibacterial activities of flavonoids: structure-activity relationship and mechanism by Xie, Yixi, Yang, Weijie, Tang, Fen, Chen, Xiaoqing, Ren, Licheng

“…Flavonoids are well known as antibacterial agents against a wide range of pathogenic microorganism. With increasing prevalence of untreatable infections…”
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Colorectal Cancer Chemotherapy: The Evolution of Treatment and New Approaches by McQuade, Rachel M, Stojanovska, Vanesa, Bornstein, Joel C, Nurgali, Kulmira

“…Colorectal cancer (CRC) is one the greatest contributors to cancer related mortality. Although 5 year survival rate for patients at the early stage of CRC…”
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Alzheimer's Disease: A Review from the Pathophysiology to Diagnosis, New Perspectives for Pharmacological Treatment by Dos Santos Picanco, Leide Caroline, Ozela, Priscilla F, de Fatima de Brito Brito, Maiara, Pinheiro, Abraao A, Padilha, Elias C, Braga, Francinaldo S, de Paula da Silva, Carlos Henrique Tomich, Dos Santos, Cleydson Breno Rodrigues, Rosa, Joaquín M C, da Silva Hage-Melim, Lorane Izabel

“…Dementia is characterized by the impairment of cognition and behavior of people over 65 years. Alzheimer's disease (AD) is the most prevalent neurodegenerative…”
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Unlocking the Potential of HK2 in Cancer Metabolism and Therapeutics by Garcia, Sara N, Guedes, Rita C, Marques, M Matilde

“…Glycolysis is a tightly regulated process in which several enzymes, such as Hexokinases (HKs), play crucial roles. Cancer cells are characterized by specific…”
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The Antidiabetic Potential of Quercetin: Underlying Mechanisms by Eid, Hoda M, Haddad, Pierre S

“…The dramatic increase in modern lifestyle diseases such as cancer, cardiovascular diseases and diabetes has renewed researchers' interest to explore nature as…”
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Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease by Guzior, Natalia, Wieckowska, Anna, Panek, Dawid, Malawska, Barbara

“…Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The available therapy is limited to the symptomatic treatment and its…”
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Dietary polyphenols and type 2 diabetes: current insights and future perspectives by Xiao, J B, Högger, P

“…Significant evidence suggests that polyphenol-rich diets have the ability to protect against diabetes. Since several previous reviews focused on the nutrition…”
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Polyoxometalates in Biomedicine: Update and Overview by Čolović, Mirjana B, Lacković, Milan, Lalatović, Jovana, Mougharbel, Ali S, Kortz, Ulrich, Krstić, Danijela Z

“…Polyoxometalates (POMs) are negatively charged metal-oxo clusters of early transition metal ions in high oxidation states (e.g., WVI, MoVI, VV). POMs are of…”
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Virtual screening strategies in drug discovery: a critical review by Lavecchia, A, Di Giovanni, C

“…Virtual screening (VS) is a powerful technique for identifying hit molecules as starting points for medicinal chemistry. The number of methods and softwares…”
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The Role of Zinc and Copper in Insulin Resistance and Diabetes Mellitus by Bjørklund, Geir, Dadar, Maryam, Pivina, Lyudmila, Doşa, Monica Daniela, Semenova, Yuliya, Aaseth, Jan

“…The prevalence of Type 2 Diabetes Mellitus (T2DM) is internationally ever-growing. Therefore, prevention, diagnostics, and control of insulin resistance and…”
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Ferroptosis: A Novel Mechanism of Artemisinin and its Derivatives in Cancer Therapy by Zhu, Shunqin, Yu, Qin, Huo, Chunsong, Li, Yuanpeng, He, Linshen, Ran, Botian, Chen, Ji, Li, Yonghao, Liu, Wanhong

“…Artemisinin is a sesquiterpene lactone compound with a special peroxide bridge that is tightly linked to the cytotoxicity involved in fighting malaria and…”
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Potential Anti-inflammatory Effects of Hesperidin from the Genus Citrus by Tejada, Silvia, Pinya, Samuel, Martorell, Miquel, Capó, Xavier, Tur, Josep A, Pons, Antoni, Sureda, Antoni

“…The benefits of the Mediterranean diet for protecting against many diseases are usually attributed to high consumption of certain foods, characterized by the…”
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Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults by De Buck, Mieke, Gouwy, Mieke, Wang, Ji Ming, Van Snick, Jacques, Opdenakker, Ghislain, Struyf, Sofie, Van Damme, Jo

“…Serum amyloid A (SAA) is, like C-reactive protein (CRP), an acute phase protein and can be used as a diagnostic, prognostic or therapy follow-up marker for…”
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Targeting the Akt/PI3K Signaling Pathway as a Potential Therapeutic Strategy for the Treatment of Pancreatic Cancer by Ebrahimi, Safieh, Hosseini, Mina, Shahidsales, Soodabeh, Maftouh, Mina, Ferns, Gordon A, Ghayour-Mobarhan, Majid, Hassanian, Seyed Mahdi, Avan, Amir

“…The phosphoinositide 3 kinase AKT mammalian target of rapamycin (PI3K-AKTmTOR) signaling pathway is an important in the aetiology of pancreatic cancer (PC) and…”
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Role of oxidative stress and molecular changes in liver fibrosis: a review by Sánchez-Valle, V, Chávez-Tapia, N C, Uribe, M, Méndez-Sánchez, N

“…Liver fibrosis represents a health problem with significant morbidity and mortality that affects 100 million people worldwide. It is a final pathway to several…”
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