Search Results - "Curren, Rodger"

Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays by Pfuhler, Stefan, Downs, Thomas R, Hewitt, Nicola J, Hoffmann, Sebastian, Mun, Greg C, Ouedraogo, Gladys, Roy, Shambhu, Curren, Rodger D, Aardema, Marilyn J

“…Abstract In vitro test batteries have become the standard approach to determine the genotoxic potential of substances of interest across industry sectors…”
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Local Tolerance Testing under REACH: Accepted Non-animal Methods are Not on Equal Footing with Animal Tests by Sauer, Ursula G., Hill, Erin H., Curren, Rodger D., Kolle, Susanne N., Teubner, Wera, Mehling, Annette, Landsiedel, Robert

“…In general, no single non-animal method can cover the complexity of any given animal test. Therefore, fixed sets of in vitro (and in chemico) methods have been…”
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The reconstructed skin micronucleus assay (RSMN) in EpiDerm™: Detailed protocol and harmonized scoring atlas by Dahl, Erica L., Curren, Rodger, Barnett, Brenda C., Khambatta, Zubin, Reisinger, Kerstin, Ouedraogo, Gladys, Faquet, Brigitte, Ginestet, Anne-Claire, Mun, Greg, Hewitt, Nicola J., Carr, Greg, Pfuhler, Stefan, Aardema, Marilyn J.

“…The European Cosmetic Toiletry and Perfumery Association (COLIPA), along with contributions from the European Centre for the Validation of Alternative Methods…”
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Vaginal irritation models: the current status of available alternative and in vitro tests by Costin, Gertrude-Emilia, Raabe, Hans A, Priston, Robert, Evans, Eric, Curren, Rodger D

“…Mucosal surfaces, such as the vaginal epithelium, are natural barriers to infection that are constantly exposed to bacteria and viruses, and are therefore…”
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International prevalidation studies of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Transferability and reproducibility by Aardema, Marilyn J., Barnett, Brenda C., Khambatta, Zubin, Reisinger, Kerstin, Ouedraogo-Arras, Gladys, Faquet, Brigitte, Ginestet, Anne-Claire, Mun, Greg C., Dahl, Erica L., Hewitt, Nicola J., Corvi, Raffallea, Curren, Rodger D.

“…Recently, a novel in vitro reconstructed skin micronucleus (RSMN) assay incorporating the EpiDerm™ 3D human skin model (Curren et al., Mutat. Res. 607 (2006)…”
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Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay by Aardema, Marilyn J., Barnett, Brenda B., Mun, Greg C., Dahl, Erica L., Curren, Rodger D., Hewitt, Nicola J., Pfuhler, Stefan

“…► The RSMN assay tested metabolically activated chemicals. ► 2 chemicals were always positive, 2 always negative. ► 1 chemical was only positive at 72h, BaP…”
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Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm™) by Curren, Rodger D., Mun, Greg C., Gibson, David P., Aardema, Marilyn J.

“…To meet the requirements of the EU 7th Amendment to the Cosmetics Directive, manufacturers of cosmetics products will need to ascertain the safety of…”
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ECVAM international validation study on in vitro tests for acute skin irritation: report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test by Spielmann, Horst, Hoffmann, Sebastian, Liebsch, Manfred, Botham, Phil, Fentem, Julia H, Eskes, Chantra, Roguet, Roland, Cotovio, José, Cole, Thomas, Worth, Andrew, Heylings, Jon, Jones, Penny, Robles, Catherine, Kandárova, Helena, Gamer, Armin, Remmele, Marina

“…ECVAM sponsored a formal validation study on three in vitro tests for skin irritation, of which two employ reconstituted human epidermis models (EPISKIN,…”
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Further development of the EpiDerm™ 3D reconstructed human skin micronucleus (RSMN) assay by Mun, Greg C., Aardema, Marilyn J., Hu, Ting, Barnett, Brenda, Kaluzhny, Yulia, Klausner, Mitchell, Karetsky, Viktor, Dahl, Erica L., Curren, Rodger D.

“…The upcoming ban on testing of cosmetics in animals by the European Union's 7th Amendment to the Cosmetics Directive will require genotoxicity safety…”
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Implementation of New Test Methods into Practical Testing by Curren, Rodger D, Poth, Albrecht, Raabe, Hans A

“…New toxicology test methods, especially those using in vitro methods, are continually being developed. Some are used by industry for screening purposes; others…”
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Intralaboratory and interlaboratory evaluation of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay by Hu, Ting, Kaluzhny, Yulia, Mun, Greg C., Barnett, Brenda, Karetsky, Viktor, Wilt, Nathan, Klausner, Mitchell, Curren, Rodger D., Aardema, Marilyn J.

“…A novel in vitro human reconstructed skin micronucleus (RSMN) assay has been developed using the EpiDerm™ 3D human skin model [R. D. Curren, G. C. Mun, D. P…”
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Ocular safety: a silent (in vitro) success story by Curren, Rodger D, Harbell, John W

“…Ocular irritation testing has been one of the animal test methods most criticised by animal welfare advocates. Additional criticism has arisen from within the…”
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In vitro human tissue models in risk assessment : Report of a consensus-building workshop by MACGREGOR, James T, COLLINS, Jerry M, KEDDERIS, Gregory L, KRISHNAN, Kannan, LI, Albert P, PARCHMENT, Ralph E, THUMMEL, Kenneth, TOMASZEWSKI, Joseph E, ULRICH, Roger, VICKERS, Alison E. M, WRIGHTON, Steven A, SUGIYAMA, Yuichi, TYSON, Charles A, DEAN, Jack, SMITH, Lewis, ANDERSEN, Melvin, CURREN, Rodger D, HOUSTON, J. Brian, KADLUBAR, Fred F

“…Advances in the technology of human cell and tissue culture and the increasing availability of human tissue for laboratory studies have led to the increased…”
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Report of an ISRTP Workshop: Progress and barriers to incorporating alternative toxicological methods in the U.S by Becker, Richard A., Borgert, Christopher J., Webb, Simon, Ansell, Jay, Amundson, Sara, Portier, Christopher J., Goldberg, Alan, Bruner, Leon H., Rowan, Andrew, Curren, Rodger D., Stott, William T.

“…The workshop objectives were to explore progress in implementing new, revised and alternative toxicological test methods across regulatory evaluation…”
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Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin Irritation. ECVAM Skin Irritation Task Force Report 2 by ZUANG, Valérie, BALLS, Michael, MEDINA, Jesus, ROGUET, Roland, VAN DE SANDT, Johannes J. M, WIEMANN, Christianne, WORTH, Andrew P, BOTHAM, Philip A, COQUETTE, Alain, CORSINI, Emanuela, CURREN, Rodger D, ELLIOTT, Graham R, FENTEM, Julia H, HEYLINGS, Jon R, LIEBSCH, Manfred

“…The European Centre for the Validation of Alternative Methods (ECVAM) Skin Irritation Task Force was established in 1996, to review the status of the…”
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Key Challenges for In Vitro Testing of Tobacco Products for Regulatory Applications: Recommendations for the In Vitro Mouse Lymphoma Assay by Crooks, Ian, Clements, Julie, Curren, Rodger, Guo, Xiaoqing, Hollings, Michael, Lloyd, Mel, Smart, Daniel, Thorne, David, Weber, Elisabeth, Moore, Martha

“…The Institute for In Vitro Sciences (IIVS) is sponsoring a series of workshops to develop recommendations for optimal scientific and technical approaches for…”
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Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT) by Pfuhler, Stefan, van Benthem, Jan, Curren, Rodger, Doak, Shareen H., Dusinska, Maria, Hayashi, Makoto, Heflich, Robert H., Kidd, Darren, Kirkland, David, Luan, Yang, Ouedraogo, Gladys, Reisinger, Kerstin, Sofuni, Toshio, van Acker, Frédérique, Yang, Ying, Corvi, Raffaella

“…•Extensive progress made in development of 3D organ-based genotoxicity assays.•3D culture models represent major exposure routes: dermal, oral, inhalation.•The…”
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Animal Use in the Chemical and Product Manufacturing Sectors - Can the Downtrend Continue? by Curren, Rodger

“…During the 1990s and early 2000s, a number of manufacturing companies in the cosmetic, personal care and household product industries were able to…”
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Investment in the Three Rs Can be Very Profitable by Curren, Rodger

“…The Principles of Humane Experimental Technique by William Russell and Rex Burch provides exceptional value, both to practitioners of alternative methodologies…”
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Report on the 2010 In Vitro Alternatives Forum by Curren, Rodger

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