Search Results - "Curran, Stephen M"

Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies against Encapsulated Protein Antigen in Young Naïve Mice after Respiratory Immunization by Parriott, Jacob E, Stewart, Jason P, Smith, D. David, Curran, Stephen M, Bauer, Christopher D, Wyatt, Todd A, Phillips, Joy A, Lyden, Elizabeth, Thiele, Geoffrey M, Vetro, Joseph A

“…Generating long-lived mucosal and systemic antibodies through respiratory immunization with protective antigens encapsulated in nanoscale biodegradable…”
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Direct Comparison of Chol-siRNA Polyplexes and Chol-DsiRNA Polyplexes Targeting STAT3 in a Syngeneic Murine Model of TNBC by Ye, Zhen, Abdelmoaty, Mai Mohamed, Curran, Stephen M, Dyavar, Shetty Ravi, Kumar, Devendra, Alnouti, Yazen, Coulter, Don W, Podany, Anthony T, Singh, Rakesh K, Vetro, Joseph A

“…RNA interference (RNAi) molecules have tremendous potential for cancer therapy but are limited by insufficient potency after intravenous (IV) administration…”
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Surface conjugation of EP67 to biodegradable nanoparticles increases the generation of long-lived mucosal and systemic memory T-cells by encapsulated protein vaccine after respiratory immunization and subsequent T-cell-mediated protection against respiratory infection by Tallapaka, Shailendra B., Karuturi, Bala V.K., Yeapuri, Pravin, Curran, Stephen M., Sonawane, Yogesh A., Phillips, Joy A., David Smith, D., Sanderson, Sam D., Vetro, Joseph A.

“…[Display omitted] Encapsulation of protein vaccines in biodegradable nanoparticles (NP) increases T-cell expansion after mucosal immunization but requires…”
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Preliminary preclinical study of Chol-DsiRNA polyplexes formed with PLL[30]-PEG[5K] for the RNAi-based therapy of breast cancer by Ye, Zhen, Abdelmoaty, Mai Mohamed, Ambardekar, Vishakha V., Curran, Stephen M., Dyavar, Shetty Ravi, Arnold, Lora L., Cohen, Samuel M., Kumar, Devendra, Alnouti, Yazen, Coulter, Don W., Singh, Rakesh K., Vetro, Joseph A.

“…RNA interference molecules have tremendous potential for cancer therapy but are limited by insufficient potency after i.v. administration. We previously found…”
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Encapsulation of an EP67-Conjugated CTL Peptide Vaccine in Nanoscale Biodegradable Particles Increases the Efficacy of Respiratory Immunization and Affects the Magnitude and Memory Subsets of Vaccine-Generated Mucosal and Systemic CD8+ T Cells in a Diameter-Dependent Manner by Karuturi, Bala V. K, Tallapaka, Shailendra B, Yeapuri, Pravin, Curran, Stephen M, Sanderson, Sam D, Vetro, Joseph A

“…The diameter of biodegradable particles used to coencapsulate immunostimulants and subunit vaccines affects the magnitude of memory CD8+ T cells generated by…”
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Complexation of Chol-DsiRNA in place of Chol-siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)-PEG(5K) in primary murine syngeneic breast tumors after i.v. administration by Ambardekar, Vishakha V., Wakaskar, Rajesh R., Ye, Zhen, Curran, Stephen M., McGuire, Timothy R., Coulter, Don W., Singh, Rakesh K., Vetro, Joseph A.

“…[Display omitted] RNA interference has tremendous potential for cancer therapy but is limited by the insufficient potency of RNAi molecules after i.v…”
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Peripherally Cross-Linking the Shell of Core-Shell Polymer Micelles Decreases Premature Release of Physically Loaded Combretastatin A4 in Whole Blood and Increases its Mean Residence Time and Subsequent Potency Against Primary Murine Breast Tumors After IV Administration by Wakaskar, Rajesh R., Bathena, Sai Praneeth R., Tallapaka, Shailendra B., Ambardekar, Vishakha V., Gautam, Nagsen, Thakare, Rhishikesh, Simet, Samantha M., Curran, Stephen M., Singh, Rakesh K., Dong, Yuxiang, Vetro, Joseph A.

“…ABSTRACT Purpose Determine the feasibility and potential benefit of peripherally cross-linking the shell of core-shell polymer micelles on the premature…”
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Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67 by Alshammari, Abdulraman M, Smith, D. David, Parriott, Jake, Stewart, Jason P, Curran, Stephen M, McCulloh, Russell J, Barry, Peter A, Iyer, Smita S, Palermo, Nicholas, Phillips, Joy A, Dong, Yuxiang, Ronning, Donald R, Vennerstrom, Jonathan L, Sanderson, Sam D, Vetro, Joseph A

“…EP67 is a second-generation, human C5a-derived decapeptide agonist of C5a receptor 1 (C5aR1/CD88) that selectively activates mononuclear phagocytes over…”
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