Search Results - "Curnow, Kathleen"

Risk of serious NSAID‐related gastrointestinal events during long‐term exposure: a systematic review by Schaffer, Delia, Florin, Timothy, Eagle, Craig, Marschner, Ian, Singh, Gurkirpal, Grobler, Mendel, Fenn, Chris, Schou, Manjula, Curnow, Kathleen M

“…Objective: Exposure to non‐steroidal anti‐inflammatory drugs (NSAIDs) is associated with increased risk of serious gastrointestinal (GI) events compared with…”
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Structural Analysis and Evaluation of the Aldosterone Synthase Gene in Hypertension by Brand, Eva, Chatelain, Nathalie, Mulatero, Paolo, Fery, Isabelle, Curnow, Kathleen, Jeunemaitre, Xavier, Corvol, Pierre, Pascoe, Leigh, Soubrier, Florent

“…Anomalies in either of the tightly linked genes encoding the enzymes CYP11B1 (11 beta-hydroxylase) or CYP11B2 (aldosterone synthase) can lead to important…”
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Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase) cause steroid 11β-hydroxylase deficiency and congenital adrenal hyperplasia by PORTRAT, Stephanie, MULATERO, Paolo, CURNOW, Kathleen M, CHAUSSAIN, Jean-Louis, MOREL, Yves, PASCOE, Leigh

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A Compound Heterozygote Case of Type II Aldosterone Synthase Deficiency by Dunlop, Felicity M., Crock, Patricia A., Montalto, Joseph, Funder, John W., Curnow, Kathleen M.

“…An infant with failure to thrive, persistent hyponatremia and episodic vomiting and diarrhea was admitted to hospital at 9 months of age, and the diagnosis of…”
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Prenatal Diagnosis and Treatment of 11β-Hydroxylase Deficiency Congenital Adrenal Hyperplasia Resulting in Normal Female Genitalia by Cerame, Barbara I, Newfield, Ron S, Pascoe, Leigh, Curnow, Kathleen M, Nimkarn, Saroj, Roe, Thomas F, New, Maria I, Wilson, Robert C

“…ABSTRACTCongenital adrenal hyperplasia (CAH) consists of autosomal recessive disorders of cortisol biosynthesis, which in the majority of cases result from…”
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The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme by Curnow, Kathleen M, Mulatero, Paolo, Emeric-Blanchouin, Nicole, Aupetit-Faisant, Brigitte, Corvol, Pierre, Pascoe, Leigh

“…Transfection studies with cDNAs encoding hybrids between the highly similar cytochrome P450 enzymes, CYP11B1 (steroid 11 beta-hydroxylase) and CYP11B2…”
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Mutations in the Human CYP11B2 (Aldosterone Synthase) Gene Causing Corticosterone Methyloxidase II Deficiency by Pascoe, Leigh, Curnow, Kathleen M., Slutsker, Liliya, Rosler, Ariel, White, Perrin C.

“…Corticosterone methyloxidase II (CMO-II) deficiency is an autosomal recessive disorder of aldosterone biosynthesis, characterized by an elevated ratio of…”
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The L10F mutation of angiotensinogen is rare in pre-eclampsia by Curnow, Kathleen M, Pham, Thao, August, Phyllis

“…BACKGROUNDA mutation in the gene for angiotensinogen, changing the leucine residue at position 10 to a phenylalanine (L10F), has been reported in a patient…”
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Sequence Similarities between a Novel Putative G Protein-Coupled Receptor and Na+/Ca2+ Exchangers Define a Cation Binding Domain by Nikkila, Heli, McMillan, D. Randy, Nunez, Brian S, Pascoe, Leigh, Curnow, Kathleen M, White, Perrin C

“…cDNA clones encoding a novel putative G protein-coupled receptor have been characterized. The receptor is widely expressed in normal solid tissues. Consisting…”
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The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex by Curnow, K M, Tusie-Luna, M T, Pascoe, L, Natarajan, R, Gu, J L, Nadler, J L, White, P C

“…The steroid 11 beta-hydroxylase (P450c11) enzyme is responsible for the conversion of 11-deoxycortisol to cortisol in the zona fasciculata of the adrenal…”
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Scaling up the ligase chain reaction-based approach to gene synthesis by Chalmers, F M, Curnow, K M

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Polar Residues in the Transmembrane Domains of the Type 1 Angiotensin II Receptor Are Required for Binding and Coupling by Monnot, Catherine, Bihoreau, Claire, Conchon, Sophie, Curnow, Kathleen M., Corvol, Pierre, Clauser, Eric

“…Type 1 angiotensin receptors (AT1) are G-protein coupled receptors, mediating the physiological actions of the vasoactive peptide angiotensin II. In this…”
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Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants by Monnot, C, Bihoreau, C, Conchon, S, Curnow, K M, Corvol, P, Clauser, E

“…Type 1 angiotensin receptors (AT1) are G-protein coupled receptors, mediating the physiological actions of the vasoactive peptide angiotensin II. In this…”
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Glucocorticoid-Suppressible Hyperaldosteronism Results from Hybrid Genes Created by Unequal Crossovers between CYP11B1 and CYP11B2 by Pascoe, Leigh, Curnow, Kathleen M., Slutsker, Liliya, John M. C. Connell, Speiser, Phyllis W., New, Maria I., White, Perrin C.

“…Glucocorticoid-suppressible hyperaldosteronism (GSH) is an autosomal dominant form of familial hypertension. The biochemical abnormalities seen in this…”
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Mutations in the CYP11B1 Gene Causing Congenital Adrenal Hyperplasia and Hypertension Cluster in Exons 6, 7, and 8 by Curnow, Kathleen M., Slutsker, Liliya, Vitek, Jiri, Cole, Trevor, Speiser, Phyllis W., New, Maria I., White, Perrin C., Pascoe, Leigh

“…Steroid 11β-hydroxylase deficiency (failure to convert 11-deoxycortisol to cortisol) is the second most common cause of congenital adrenal hyperplasia and…”
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A compound heterozygote case of type II aldosterone synthase deficiency : Cardiovascular endocrinology: Original articles by DUNLOP, Felicity M, CROCK, Patricia A, MONTALTO, Joseph, FUNDER, John W, CURNOW, Kathleen M

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Deletion Hybrid Genes, due to Unequal Crossing Over between CYP11B1 (11β-Hydroxylase) and CYP11B2(Aldosterone Synthase) Cause Steroid 11β-Hydroxylase Deficiency and Congenital Adrenal Hyperplasia1 by Portrat, Stephanie, Mulatero, Paolo, Curnow, Kathleen M., Chaussain, Jean-Louis, Morel, Yves, Pascoe, Leigh

“…Chromosomal rearrangements are natural experiments that can provide unique insights into in vivo regulation of genes and physiological systems. We have studied…”
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Deletion Hybrid Genes, due to Unequal Crossing Over between CYP11B1 (11β-Hydroxylase) and CYP11B2 (Aldosterone Synthase) Cause Steroid 11β-Hydroxylase Deficiency and Congenital Adrenal Hyperplasia 1 by Portrat, Stephanie, Mulatero, Paolo, Curnow, Kathleen M., Chaussain, Jean-Louis, Morel, Yves, Pascoe, Leigh

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Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms by Curnow, K M, Pascoe, L, Davies, E, White, P C, Corvol, P, Clauser, E

“…The peptide hormone angiotensin II (AngII) plays a principal role in regulating blood pressure and fluid homeostasis. Most of its known effects are mediated by…”
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Genetic analysis of the human type-1 angiotensin II receptor by Curnow, K M, Pascoe, L, White, P C

“…Angiotensin II is a potent pressor hormone and a primary regulator of aldosterone secretion. It acts through at least two types of receptors termed AT1 and…”
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