Search Results - "Curiel, T"

Adenoviral vector vaccine platforms in the SARS-CoV-2 pandemic by Mendonça, Samir Andrade, Lorincz, Reka, Boucher, Paul, Curiel, David T.

“…Adenoviral vectors have been explored as vaccine agents for a range of infectious diseases, and their ability to induce a potent and balanced immune response…”
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A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2 by Hassan, Ahmed O., Kafai, Natasha M., Dmitriev, Igor P., Fox, Julie M., Smith, Brittany K., Harvey, Ian B., Chen, Rita E., Winkler, Emma S., Wessel, Alex W., Case, James Brett, Kashentseva, Elena, McCune, Broc T., Bailey, Adam L., Zhao, Haiyan, VanBlargan, Laura A., Dai, Ya-Nan, Ma, Meisheng, Adams, Lucas J., Shrihari, Swathi, Danis, Jonathan E., Gralinski, Lisa E., Hou, Yixuan J., Schäfer, Alexandra, Kim, Arthur S., Keeler, Shamus P., Weiskopf, Daniela, Baric, Ralph S., Holtzman, Michael J., Fremont, Daved H., Curiel, David T., Diamond, Michael S.

“…The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a…”
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Long-term correction of hemophilia B using adenoviral delivery of CRISPR/Cas9 by Stephens, Calvin J., Lauron, Elvin J., Kashentseva, Elena, Lu, Zhi Hong, Yokoyama, Wayne M., Curiel, David T.

“…Hemophilia B (HB) is a life-threatening inherited disease caused by mutations in the FIX gene, leading to reduced protein function and abnormal blood clotting…”
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Targeted in vivo knock-in of human alpha-1-antitrypsin cDNA using adenoviral delivery of CRISPR/Cas9 by Stephens, Calvin J., Kashentseva, Elena, Everett, William, Kaliberova, Lyudmila, Curiel, David T.

“…Serum deficiency diseases such as alpha-1-antitrypsin deficiency are characterized by reduced function of serum proteins, caused by deleterious genetic…”
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An intranasal vaccine durably protects against SARS-CoV-2 variants in mice by Hassan, Ahmed O., Shrihari, Swathi, Gorman, Matthew J., Ying, Baoling, Yaun, Dansu, Raju, Saravanan, Chen, Rita E., Dmitriev, Igor P., Kashentseva, Elena, Adams, Lucas J., Mann, Colin, Davis-Gardner, Meredith E., Suthar, Mehul S., Shi, Pei-Yong, Saphire, Erica Ollmann, Fremont, Daved H., Curiel, David T., Alter, Galit, Diamond, Michael S.

“…SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally…”
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Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells by Zou, Weiping, Curiel, Tyler J, Machelon, Véronique, Coulomb-L'Hermin, Aurore, Borvak, Jozef, Nome, Françoise, Isaeva, Tatyana, Wei, Shuang, Krzysiek, Roman, Durand-Gasselin, Ingrid, Gordon, Alan, Pustilnik, Terri, Curiel, David T, Galanaud, Pierre, Capron, Frédérique, Emilie, Dominique

“…Dendritic-cell (DC) trafficking and function in tumors is poorly characterized, with studies confined to myeloid DCs (DC1s). Tumors inhibit DC1 migration and…”
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Considerations for successful cancer immunotherapy in aged hosts by Hurez, V., Padrón, Á. S., Svatek, R. S., Curiel, T. J.

“…Summary Immunotherapy is now experiencing unprecedented successes in treating various cancers based on new understandings of cancer immunopathogenesis…”
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Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma by Chastkofsky, Michael I, Pituch, Katarzyna C, Katagi, Hiroaki, Zannikou, Markella, Ilut, Liliana, Xiao, Ting, Han, Yu, Sonabend, Adam M, Curiel, David T, Bonner, Erin R, Nazarian, Javad, Horbinski, Craig M, James, C David, Saratsis, Amanda M, Hashizume, Rintaro, Lesniak, Maciej S, Balyasnikova, Irina V

“…Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers…”
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A single intranasal dose of chimpanzee adenovirus-vectored vaccine protects against SARS-CoV-2 infection in rhesus macaques by Hassan, Ahmed O., Feldmann, Friederike, Zhao, Haiyan, Curiel, David T., Okumura, Atsushi, Tang-Huau, Tsing-Lee, Case, James Brett, Meade-White, Kimberly, Callison, Julie, Chen, Rita E., Lovaglio, Jamie, Hanley, Patrick W., Scott, Dana P., Fremont, Daved H., Feldmann, Heinz, Diamond, Michael S.

“…The deployment of a vaccine that limits transmission and disease likely will be required to end the coronavirus disease 2019 (COVID-19) pandemic. We recently…”
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Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity by Curiel, Tyler J, Zou, Weiping, Wei, Shuang, Dong, Haidong, Alvarez, Xavier, Cheng, Pui, Mottram, Peter, Krzysiek, Roman, Knutson, Keith L, Daniel, Ben, Zimmermann, Maria Carla, David, Odile, Burow, Matthew, Gordon, Alan, Dhurandhar, Nina, Myers, Leann, Berggren, Ruth, Hemminki, Akseli, Alvarez, Ronald D, Emilie, Dominique, Curiel, David T, Chen, Lieping

“…Suppression of dendritic cell function in cancer patients is thought to contribute to the inhibition of immune responses and disease progression. Molecular…”
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Blood clearance rates of adenovirus type 5 in mice by Alemany, Ramon, Suzuki, Kaori, Curiel, David T

“…Division of Human Gene Therapy, University of Alabama at Birmingham, Room 614, Wallace Tumor Institute, 1824 Sixth Avenue South, Birmingham, AL 35294, USA 1…”
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Mesenchymal progenitor cells as cellular vehicles for delivery of oncolytic adenoviruses by Komarova, Svetlana, Kawakami, Yosuke, Stoff-Khalili, Mariam A, Curiel, David T, Pereboeva, Larisa

“…Natural and genetically modified oncolytic viruses have been systematically tested as anticancer therapeutics. Among this group, conditionally replicative…”
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Replicative adenoviruses for cancer therapy by Curiel, David T, Alemany, Ramon, Balagué, Cristina

“…Rapid advances are being made in the engineering of replication-competent viruses to treat cancer. Adenovirus is a mildly pathogenic human virus that…”
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Radiation-induced cell signaling: inside-out and outside-in by Valerie, Kristoffer, Yacoub, Adly, Hagan, Michael P, Curiel, David T, Fisher, Paul B, Grant, Steven, Dent, Paul

“…Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA damage as well as mitochondria-dependent generation of reactive oxygen…”
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A Gorilla Adenovirus-Based Vaccine against Zika Virus Induces Durable Immunity and Confers Protection in Pregnancy by Hassan, Ahmed O., Dmitriev, Igor P., Kashentseva, Elena A., Zhao, Haiyan, Brough, Douglas E., Fremont, Daved H., Curiel, David T., Diamond, Michael S.

“…The teratogenic potential of Zika virus (ZIKV) has made the development of an effective vaccine a global health priority. Here, we generate two gorilla…”
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The N-Terminal Domain of SIRT1 Is a Positive Regulator of Endogenous SIRT1-Dependent Deacetylation and Transcriptional Outputs by Ghisays, Fiorella, Brace, Cynthia S., Yackly, Shawn M., Kwon, Hyock Joo, Mills, Kathryn F., Kashentseva, Elena, Dmitriev, Igor P., Curiel, David T., Imai, Shin-ichiro, Ellenberger, Tom

“…The NAD+-dependent protein deacetylase SIRT1 regulates energy metabolism, responses to stress, and aging by deacetylating many different proteins, including…”
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Engineering a Novel Modular Adenoviral mRNA Delivery Platform Based on Tag/Catcher Bioconjugation by Geng, Kexin, Rice-Boucher, Paul J, Kashentseva, Elena A, Dmitriev, Igor P, Lu, Zhi Hong, Goedegebuure, S Peter, Gillanders, William E, Curiel, David T

“…mRNA vaccines have attracted widespread research attention with clear advantages in terms of molecular flexibility, rapid development, and potential for…”
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In vivo editing of the pan-endothelium by immunity evading simian adenoviral vector by Lorincz, Reka, Alvarez, Aluet Borrego, Walkey, Christopher J., Mendonça, Samir A., Lu, Zhi Hong, Martinez, Alexa E., Ljungberg, Cecilia, Heaney, Jason D., Lagor, William R., Curiel, David T.

“…Biological applications deriving from the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 site-specific nuclease system continue to…”
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Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity by Dash, Rupesh, Azab, Belal, Quinn, Bridget A, Shen, Xuening, Wang, Xiang-Yang, Das, Swadesh K, Rahmani, Mohamed, Wei, Jun, Hedvat, Michael, Dent, Paul, Dmitriev, Igor P, Curiel, David T, Grant, Steven, Wu, Bainan, Stebbins, John L, Pellecchia, Maurizio, Reed, John C, Sarkar, Devanand, Fisher, Paul B

“…Limited options are available for treating patients with advanced prostate cancer (PC). Melanoma differentiation associated gene-7/interleukin-24…”
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In Vitro and In Vivo Efficacy of a Stroma-Targeted, Tumor Microenvironment Responsive Oncolytic Adenovirus in Different Preclinical Models of Cancer by Alfano, Ana, Cafferata, Eduardo G A, Gangemi, Mariela, Nicola Candia, Alejandro, Malnero, Cristian M, Bermudez, Ismael, Lopez, Mauricio Vargas, Ríos, Gregorio David, Rotondaro, Cecilia, Cuneo, Nicasio, Curiel, David T, Podhajcer, Osvaldo L, Lopez, Maria Veronica

“…More than one million women are diagnosed annually worldwide with a gynecological cancer. Most gynecological cancers are diagnosed at a late stage, either…”
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