Search Results - "Cuny, Gregory"

RIPK protein kinase family: Atypical lives of typical kinases by Cuny, Gregory D., Degterev, Alexei

“…Receptor Interacting Protein Kinases (RIPKs) are a family of Ser/Thr/Tyr kinases whose functions, regulation and pathophysiologic roles have remained an enigma…”
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A Mild, One-Pot Stadler-Ziegler Synthesis of Arylsulfides Facilitated by Photoredox Catalysis in Batch and Continuous-Flow by Wang, Xiao, Cuny, Gregory D., Noël, Timothy

“…Visible advance: A mild, one‐pot Stadler–Ziegler process for CS bond formation has been developed. The method employs the photoredox catalyst [Ru(bpy)3Cl2]⋅6…”
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Syntheses of Gymnothespirolignans B and C and Non-natural Isomer 9‑Epi-gymnothespirolignan B by Ali, Ghada, Cuny, Gregory D

“…Syntheses of polycyclic spiro lignans gymnothespirolignans B and C as well as the unnatural isomer 9-epi-gymnothespirolignan B were accomplished using…”
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A new class of small molecule inhibitor of BMP signaling by Sanvitale, Caroline E, Kerr, Georgina, Chaikuad, Apirat, Ramel, Marie-Christine, Mohedas, Agustin H, Reichert, Sabine, Wang, You, Triffitt, James T, Cuny, Gregory D, Yu, Paul B, Hill, Caroline S, Bullock, Alex N

“…Growth factor signaling pathways are tightly regulated by phosphorylation and include many important kinase targets of interest for drug discovery. Small…”
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8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities by Ali, Ghada, Cuny, Gregory D.

“…Aporphines, a major group of aporphinoid alkaloids, exhibit interesting and diverse pharmacological activities. A set of dimeric aporphines with an aryloxy…”
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Microwave assisted copper-free Sonogashira coupling/5-exo- dig cycloisomerization domino reaction: access to 3-(phenylmethylene)isoindolin-1-ones and related heterocycles by Hellal, Malik, Cuny, Gregory D.

“…An efficient microwave assisted one-pot synthesis of substituted 3-(phenylmethylene)isoindolin-1-ones is reported via a copper-free Sonogashira coupling and a…”
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Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1 by Najjar, Malek, Suebsuwong, Chalada, Ray, Soumya S., Thapa, Roshan J., Maki, Jenny L., Nogusa, Shoko, Shah, Saumil, Saleh, Danish, Gough, Peter J., Bertin, John, Yuan, Junying, Balachandran, Siddharth, Cuny, Gregory D., Degterev, Alexei

“…RIPK1 and RIPK3, two closely related RIPK family members, have emerged as important regulators of pathologic cell death and inflammation. In the current work,…”
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Identification of RIP1 kinase as a specific cellular target of necrostatins by Degterev, Alexei, Yuan, Junying, Hitomi, Junichi, Germscheid, Megan, Ch'en, Irene L, Korkina, Olga, Teng, Xin, Abbott, Derek, Cuny, Gregory D, Yuan, Chengye, Wagner, Gerhard, Hedrick, Stephen M, Gerber, Scott A, Lugovskoy, Alexey

“…Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective…”
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Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease by Xu, Jian, Chatterjee, Manavi, Baguley, Tyler D, Brouillette, Jonathan, Kurup, Pradeep, Ghosh, Debolina, Kanyo, Jean, Zhang, Yang, Seyb, Kathleen, Ononenyi, Chimezie, Foscue, Ethan, Anderson, George M, Gresack, Jodi, Cuny, Gregory D, Glicksman, Marcie A, Greengard, Paul, Lam, TuKiet T, Tautz, Lutz, Nairn, Angus C, Ellman, Jonathan A, Lombroso, Paul J

“…STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and…”
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Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage by Zeng, Xing, Sigoillot, Frederic, Gaur, Shantanu, Choi, Sungwoon, Pfaff, Kathleen L., Oh, Dong-Chan, Hathaway, Nathaniel, Dimova, Nevena, Cuny, Gregory D., King, Randall W.

“…Microtubule inhibitors are important cancer drugs that induce mitotic arrest by activating the spindle assembly checkpoint (SAC), which, in turn, inhibits the…”
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Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell by Pawlowic, Mattie C., Somepalli, Mastanbabu, Sateriale, Adam, Herbert, Gillian T., Gibson, Alexis R., Cuny, Gregory D., Hedstrom, Lizbeth, Striepen, Boris

“…The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal disease and an important contributor to early-childhood mortality…”
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Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling by Nikhar, Sameer, Siokas, Ioannis, Schlicher, Lisa, Lee, Seungheon, Gyrd-Hansen, Mads, Degterev, Alexei, Cuny, Gregory D.

“…Receptor interacting protein kinase-2 (RIPK2) is an enzyme involved in the transduction of pro-inflammatory nucleotide-binding oligomerization domain (NOD)…”
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Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells by Mistry, Helena, Hsieh, Grace, Buhrlage, Sara J, Huang, Min, Park, Eunmi, Cuny, Gregory D, Galinsky, Ilene, Stone, Richard M, Gray, Nathanael S, D'Andrea, Alan D, Parmar, Kalindi

“…Inhibitor of DNA binding 1 (ID1) transcription factor is essential for the proliferation and progression of many cancer types, including leukemia. However, the…”
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A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex by Chen, Han, Lye, Ming F, Gorgulla, Christoph, Ficarro, Scott B, Cuny, Gregory D, Scott, David A, Wu, Fan, Rothlauf, Paul W, Wang, Xiaoou, Fernandez, Rosio, Pesola, Jean M, Draga, Sorin, Marto, Jarrod A, Hogle, James M, Arthanari, Haribabu, Coen, Donald M

“…Human cytomegalovirus (HCMV) is an important pathogen for which new antiviral drugs are needed. HCMV, like other herpesviruses, encodes a nuclear egress…”
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Development of Rofecoxib-Based Fluorescent Probes and Investigations on Their Solvatochromism, AIE Activity, Mechanochromism, and COX-2-Targeted Bioimaging by Xie, Lijun, Li, Renfu, Zheng, Biyun, Xie, Zuoxu, Fang, Xuefen, Wang, Yanqi, Cuny, Gregory D, Li, Zhenli, Lin, Bin, Chen, Xueyuan, Hu, Ming

“…Cyclooxygenase-2 (COX-2) fluorescent probes are promising tools for early diagnosis of cancer. Traditionally, COX-2 probes were designed by connecting two…”
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Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease by Takahashi, Kou, Kong, Qiongman, Lin, Yuchen, Stouffer, Nathan, Schulte, Delanie A, Lai, Liching, Liu, Qibing, Chang, Ling-Chu, Dominguez, Sky, Xing, Xuechao, Cuny, Gregory D, Hodgetts, Kevin J, Glicksman, Marcie A, Lin, Chien-Liang Glenn

“…Glutamatergic systems play a critical role in cognitive functions and are known to be defective in Alzheimer's disease (AD) patients. Previous literature has…”
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BMP type I receptor inhibition reduces heterotopic ossification by Yu, Paul B, Deng, Donna Y, Lai, Carol S, Hong, Charles C, Cuny, Gregory D, Bouxsein, Mary L, Hong, Deborah W, McManus, Patrick M, Katagiri, Takenobu, Sachidanandan, Chetana, Kamiya, Nobuhiro, Fukuda, Tomokazu, Mishina, Yuji, Peterson, Randall T, Bloch, Kenneth D

“…Ectopic ossification often involves the transformation of soft tissue into bone. In this new study, Paul Yu et al. show that inflammation is a key step in…”
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Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model by Rosenbaum, Daniel M., Degterev, Alexei, David, Joel, Rosenbaum, Pearl S., Roth, Steven, Grotta, James C., Cuny, Gregory D., Yuan, Junying, Savitz, Sean I.

“…Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional…”
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Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis by McNamara, Colleen R, Ahuja, Ruchita, Osafo-Addo, Awo D, Barrows, Douglas, Kettenbach, Arminja, Skidan, Igor, Teng, Xin, Cuny, Gregory D, Gerber, Scott, Degterev, Alexei

“…Necroptosis is a regulated form of necrotic cell death that has been implicated in the pathogenesis of various diseases including intestinal inflammation and…”
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Structure–Activity Relationship of 3,5-Diaryl-2-aminopyridine ALK2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants by Mohedas, Agustin H, Wang, You, Sanvitale, Caroline E, Canning, Peter, Choi, Sungwoon, Xing, Xuechao, Bullock, Alex N, Cuny, Gregory D, Yu, Paul B

“…There are currently no effective therapies for fibrodysplasia ossificans progressiva (FOP), a debilitating and progressive heterotopic ossification disease…”
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