Search Results - "Cunnusamy, Khrishen"

IL-17 promotes immune privilege of corneal allografts by Cunnusamy, Khrishen, Chen, Peter W, Niederkorn, Jerry Y

“…Corneal allograft rejection has been described as a Th1-mediated process involving IFN-γ production. However, it has been reported that corneal allograft…”
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TCF4 Triplet Repeat Expansion and Nuclear RNA Foci in Fuchs' Endothelial Corneal Dystrophy by Mootha, V Vinod, Hussain, Imran, Cunnusamy, Khrishen, Graham, Eric, Gong, Xin, Neelam, Sudha, Xing, Chao, Kittler, Ralf, Petroll, W Matthew

“…Expansion of the intronic CTG18.1 triplet repeat locus within TCF4 contributes significant risk to the development of Fuchs' endothelial corneal dystrophy…”
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Pharmaceutical composition for treating macular degeneration (WO2012079419) by Wang, Shusheng, Cunnusamy, Khrishen

“…A pharmaceutical composition composed of several traditional Chinese medicines is claimed to treat age-related macular degeneration (AMD). This represents a…”
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IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts by Cunnusamy, Khrishen, Chen, Peter W, Niederkorn, Jerry Y

“…IL-17A is a proinflammatory cytokine that has received attention for its role in the pathogenesis of several autoimmune diseases. IL-17A has also been…”
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Immunobiology of antigen presenting cells during relapse vs. remission in multiple sclerosis by Sinha, Sushmita, Cunnusamy, Khrishen, Chaudhary, Parul, Greenberg, Benjamin M, Frohman, Elliot M, Karandikar, Nitin J

“…Multiple sclerosis (MS) is the most common cause of neurological disability in young adults. Approximately 80% of MS patients initially present with the…”
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The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis by Ortega, Sterling B, Kashi, Venkatesh P, Tyler, Andrew F, Cunnusamy, Khrishen, Mendoza, Jason P, Karandikar, Nitin J

“…Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the CNS, and CD8 T cells are the predominant T cell population in MS lesions. Given that…”
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Disease exacerbation of multiple sclerosis is characterized by loss of terminally differentiated autoregulatory CD8+ T cells by Cunnusamy, Khrishen, Baughman, Ethan J, Franco, Jorge, Ortega, Sterling B, Sinha, Sushmita, Chaudhary, Parul, Greenberg, Benjamin M, Frohman, Elliot M, Karandikar, Nitin J

“…Abstract Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS). Although its etiology remains unknown,…”
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Identification of a Novel Gene, CIA6, Required for Normal Pyrenoid Formation in Chlamydomonas reinhardtii by Ma, Yunbing, Pollock, Steve V., Xiao, Ying, Cunnusamy, Khrishen, Moroney, James V.

“…Chlamydomonas reinhardtii possesses a CO₂-concentrating mechanism (CCM) that allows the alga to grow at low CO₂ concentrations. One common feature seen in…”
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IFN‐γ Blocks CD4+CD25+ Tregs and Abolishes Immune Privilege of Minor Histocompatibility Mismatched Corneal Allografts by Cunnusamy, K., Niederkorn, J. Y.

“…Th1 CD4+ cells are believed to be the primary mediators of corneal allograft rejection. However, rejection of fully allogeneic C57BL/6 corneal allografts…”
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Two different regulatory T cell populations that promote corneal allograft survival by Cunnusamy, Khrishen, Paunicka, Kathryn, Reyes, Nancy, Yang, Wanhua, Chen, Peter W, Niederkorn, Jerry Y

“…To compare and contrast the T regulatory cells (Tregs) induced by anterior chamber (AC) injection of antigen with those induced by orthotopic corneal…”
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Congenital Corneal Endothelial Dystrophies Resulting From Novel De Novo Mutations by Cunnusamy, Khrishen, Bowman, Charles B, Beebe, Walter, Gong, Xin, Hogan, R Nick, Mootha, V Vinod

“…PURPOSE:To describe 2 cases of congenital corneal endothelial edema resulting from novel de novo mutations. METHODS:Case A patient was a 15-month-old white…”
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Autoregulatory CD8 T cells modulate CNS autoimmunity by targeting encephalitogenic CD4 T cells (P4130) by Ortega, Sterling, Kashi, Venkatesh, Tyler, Andrew, Mendoza, Jason, Cunnusamy, Khrishen, Karandikar, Nitin

“…Multiple Sclerosis (MS) is an inflammatory demyelinating disease with a preponderance of CD8 T-cells in central nervous system (CNS) lesions. We have…”
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Disease exacerbation in multiple sclerosis patients is characterized by loss of terminally differentiated neuroantigen-specific CD8+ Tregs (P3115) by Cunnusamy, Khrishen, Baughman, Ethan, Franco, Jorge, Ortega, Sterling, Greenberg, Benjamin, Frohman, Elliot, Karandikar, Nitin

“…Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system (CNS) that afflicts more than 400,000 people in the US…”
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Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis (P5189) by Sinha, Sushmita, Ayers, Chris, Mendoza, Jason, Cunnusamy, Khrishen, Greenberg, Benjamin, Frohman, Elliot, Karandikar, Nitin

“…Daily subcutaneous administration of FDA-approved glatiramer acetate (GA) has beneficial effects on clinical course of relapsing remitting multiple sclerosis…”
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IL-17A-dependent CD4+CD25+ Tregs Promote Immune Privilege of Corneal Allografts by Cunnusamy, Khrishen, Chen, Peter W., Niederkorn, Jerry Y.

“…IL-17A is a pro-inflammatory cytokine that has received attention for its role in the pathogenesis of several autoimmune diseases. IL-17A has also been…”
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The Disease Ameliorating Function of Autoregulatory CD8 T-cells Is Mediated by Targeting of Encephalitogenic CD4 T-cells in EAE by Ortega, Sterling B., Kashi, Venkatesh P., Tyler, Andrew F., Cunnusamy, Khrishen, Mendoza, Jason P., Karandikar, Nitin J.

“…Multiple Sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS) and CD8 T-cells are the predominant T-cell population…”
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Identification and characterization of two closely related β-carbonic anhydrases from Chlamydomonas reinhardtii by Ynalvez, Ruby A, Xiao, Ying, Ward, Ayana S, Cunnusamy, Khrishen, Moroney, James V

“…Aquatic photosynthetic organisms such as the green alga Chlamydomonas reinhardtii respond to low-CO₂ conditions by inducing a CO₂ concentrating mechanism…”
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Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis by Ayers, Chris L, Mendoza, Jason P, Sinha, Sushmita, Cunnusamy, Khrishen, Greenberg, Benjamin M, Frohman, Elliot M, Karandikar, Nitin J

“…Abstract Daily administration of FDA-approved glatiramer acetate (GA) has beneficial effects on clinical course of relapsing remitting multiple sclerosis…”
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Autoregulatory CD8 T cells depend on cognate antigen recognition and CD4/CD8 myelin determinants by Ortega, Sterling B, Kashi, Venkatesh P, Cunnusamy, Khrishen, Franco, Jorge, Karandikar, Nitin J

“…OBJECTIVE:To determine the antigenic determinants and specific molecular requirements for the generation of autoregulatory neuroantigen-specific CD8 T cells in…”
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Paradigm shifts in the role of CD4+ T cells in keratoplasty by Cunnusamy, Khrishen, Chen, Peter W, Niederkorn, Jerry Y

“…Corneal transplantation is the oldest, most common, and arguably the most successful form of organ transplantation. In uncomplicated first-time cases, corneal…”
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