Search Results - "Cunningham, Richard P."

Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA by Pang, Bo, McFaline, Jose L, Burgis, Nicholas E, Dong, Min, Taghizadeh, Koli, Sullivan, Matthew R, Elmquist, C. Eric, Cunningham, Richard P, Dedon, Peter C

“…Deamination of nucleobases in DNA and RNA results in the formation of xanthine (X), hypoxanthine (I), oxanine, and uracil, all of which are miscoding and…”
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Substrate Specificity of RdgB Protein, a Deoxyribonucleoside Triphosphate Pyrophosphohydrolase by Burgis, Nicholas E., Cunningham, Richard P.

“…We have previously reported the identification of a DNA repair system in Escherichia coli for the prevention of the stable incorporation of noncanonical purine…”
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Quantitative in vitro and in vivo characterization of the human P32T mutant ITPase by Herting, Greg, Barber, Katie, Zappala, Maria R., Cunningham, Richard P., Burgis, Nicholas E.

“…Human ITPase, encoded by the ITPA gene, and its orthologs (RdgB in Escherichia coli and HAM1 in Saccharomyces cerevisiae) exclude noncanonical nucleoside…”
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Targeted Deletion of mNth1 Reveals a Novel DNA Repair Enzyme Activity by Ocampo, Maria T. A., Chaung, Wenren, Marenstein, Dina R., Chan, Michael K., Altamirano, Alvin, Basu, Ashis K., Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structure and function of the multifunctional DNA-repair enzyme exonuclease III by Mol, Clifford D, Kuo, Che-Fu, Thayer, Maria M, Cunningham, Richard P, Tainer, John A

“…The repair of DNA requires the removal of abasic sites, which are constantly generated in vivo both spontaneously and by enzymatic removal of uracil, and of…”
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Role of endonuclease III enzymes in uracil repair by Yang, Ye, Park, Sung-Hyun, Alford-Zappala, Maria, Lee, Hyun-Wook, Li, Jing, Cunningham, Richard P, Cao, Weiguo

“…Endonuclease III is a DNA glycosylase previously known for its repair activity on oxidative pyrimidine damage. Uracil is a deamination product derived from…”
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Repair System for Noncanonical Purines in Escherichia coli by Burgis, Nicholas E, Brucker, Jason J, Cunningham, Richard P

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Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes by Tsutakawa, Susan E., Shin, David S., Mol, Clifford D., Izumi, Tadahide, Arvai, Andrew S., Mantha, Anil K., Szczesny, Bartosz, Ivanov, Ivaylo N., Hosfield, David J., Maiti, Buddhadev, Pique, Mike E., Frankel, Kenneth A., Hitomi, Kenichi, Cunningham, Richard P., Mitra, Sankar, Tainer, John A.

“…Non-coding apurinic/apyrimidinic (AP) sites in DNA form spontaneously and as DNA base excision repair intermediates are the most common toxic and mutagenic in…”
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The PX Motif of DNA Binds Specifically to Escherichia coli DNA Polymerase I by Gao, Xiang, Gethers, Matthew, Han, Si-ping, Goddard, William A, Sha, Ruojie, Cunningham, Richard P, Seeman, Nadrian C

“…The PX motif of DNA is a four-stranded structure in which two parallel juxtaposed double-helical domains are fused by crossovers at every point where the…”
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Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis–trans epimerization by Ocampo-Hafalla, Maria T., Altamirano, Alvin, Basu, Ashis K., Chan, Michael K., Ocampo, Jose Eliseo A., Cummings, Archie, Boorstein, Robert J., Cunningham, Richard P., Teebor, George W.

“…Oxidation of thymine yields 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol. Tg) which, as cis 5S,6R and 5R,6S 2’-deoxyribonucleoside diastereoisomers (dTg1,…”
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Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases by Mol, Clifford D, Arvai, Andrew S, Begley, Thomas J, Cunningham, Richard P, Tainer, John A

“…The repair of T:G mismatches in DNA is key for maintaining bacterial restriction/modification systems and gene silencing in higher eukaryotes. T:G mismatch…”
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Human endonuclease V as a repair enzyme for DNA deamination by Mi, Rongjuan, Alford-Zappala, Maria, Kow, Yoke W, Cunningham, Richard P, Cao, Weiguo

“…The human endonuclease V gene is located in chromosome 17q25.3 and encodes a 282 amino acid protein that shares about 30% sequence identity with bacterial…”
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The role of sequence context, nucleotide pool balance and stress in 2'-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA by Wang, Jin, Dong, Hongping, Chionh, Yok Hian, McBee, Megan E, Sirirungruang, Sasilada, Cunningham, Richard P, Shi, Pei-Yong, Dedon, Peter C

“…The misincorporation of 2'-deoxyribonucleotides (dNs) into RNA has important implications for the function of non-coding RNAs, the translational fidelity of…”
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DNA Sequence Context Conceals α-Anomeric Lesions by Johnson, Christopher N., Spring, Alexander M., Desai, Sunil, Cunningham, Richard P., Germann, Markus W.

“…DNA sequence context has long been known to modulate detection and repair of DNA damage. Recent studies using experimental and computational approaches have…”
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DNA apurinic-apyrimidinic site binding and excision by endonuclease IV by Garcin, Elsa D, Hosfield, David J, Desai, Sunil A, Haas, Brian J, Björas, Magnar, Cunningham, Richard P, Tainer, John A

“…Escherichia coli endonuclease IV is an archetype for an abasic or apurinic-apyrimidinic endonuclease superfamily crucial for DNA base excision repair. Here…”
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Purification of a Mammalian Homologue of Escherichia coli Endonuclease III:  Identification of a Bovine Pyrimidine Hydrate-Thymine Glycol DNA-Glycosylase/AP Lyase by Irreversible Cross Linking to a Thymine Glycol-Containing Oligodeoxynucleotide by Hilbert, Timothy P, Boorstein, Robert J, Kung, Hsiang Chuan, Bolton, Philip H, Xing, Dongxia, Cunningham, Richard P, Teebor, George W

“…We purified a homologue of the Escherichia coli DNA repair enzyme endonuclease III 5000-fold from calf thymus which, like endonuclease III, demonstrates…”
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Stereochemical studies of the .beta.-elimination reactions at aldehydic abasic sites in DNA: endonuclease III from Escherichia coli, sodium hydroxide, and Lys-Trp-Lys by Mazumder, Abhijit, Gerlt, John A, Absalon, Michael J, Stubbe, JoAnne, Cunningham, Richard P, Withka, Jane, Bolton, Philip H

“…The DNA strand cleavage reaction catalyzed by endonuclease III from Escherichia coli (endo III) on the 3'-side of aldehyde abasic sites proceeds by a syn…”
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Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene by Asahara, Hitomi, Wistort, Peter M, Bank, Janet F, Bakerian, Ronald H, Cunningham, Richard P

“…The gene which codes for endonuclease III of Escherichia coli has been sequenced. The nth gene was previously subcloned and defined as the gene which led to…”
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Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity by Marenstein, Dina R, Chan, Michael K, Altamirano, Alvin, Basu, Ashis K, Boorstein, Robert J, Cunningham, Richard P, Teebor, George W

“…Base excision repair of oxidized pyrimidines in human DNA is initiated by the DNA N-glycosylase/apurinic/apyrimidinic (AP) lyase, human NTH1 (hNTH1), the…”
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Cross-species Functionome analysis identifies proteins associated with DNA repair, translation and aerobic respiration as conserved modulators of UV-toxicity by Rooney, John P., Patil, Ashish, Joseph, Fraulin, Endres, Lauren, Begley, Ulrike, Zappala, Maria R., Cunningham, Richard P., Begley, Thomas J.

“…Cellular responses to DNA damage can prevent mutations and death. In this study, we have used high throughput screens and developed a comparative genomic…”
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