Search Results - "Cunningham, Debbie L."

LAR protein tyrosine phosphatase regulates focal adhesions through CDK1 by Sarhan, Adil R, Patel, Trushar R, Cowell, Alana R, Tomlinson, Michael G, Hellberg, Carina, Heath, John K, Cunningham, Debbie L, Hotchin, Neil A

“…Focal adhesions are complex multi-molecular structures that link the actin cytoskeleton to the extracellular matrix through integrin adhesion receptors and…”
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A Dual Role for FADD in Human Precursor T-Cell Neoplasms by Marín-Rubio, José Luis, Vela-Martín, Laura, Gudgeon, Jack, Pérez-Gómez, Eduardo, Sidgwick, Frances R, Trost, Matthias, Cunningham, Debbie L, Santos, Javier, Fernández-Piqueras, José, Villa-Morales, María

“…A reduction in levels has been reported in precursor T-cell neoplasms and other tumor types. Such reduction would impact on the ability of tumor cells to…”
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Combined transcriptomic and phosphoproteomic analysis of BMP4 signaling in human embryonic stem cells by Papadopoulos, Angelos, Chalmantzi, Varvara, Mikhaylichenko, Olga, Hyvönen, Marko, Stellas, Dimitris, Kanhere, Aditi, Heath, John, Cunningham, Debbie L., Fotsis, Theodore, Murphy, Carol

“…•BMP4 induction negatively regulates the TGFβ pathway in hESCs.•BMP4 induces the phosphorylation of proteins associated with transcriptional regulation. Human…”
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SLoMo: Automated Site Localization of Modifications from ETD/ECD Mass Spectra by Bailey, Christopher M, Sweet, Steve M. M, Cunningham, Debbie L, Zeller, Martin, Heath, John K, Cooper, Helen J

“…Recently, software has become available to automate localization of phosphorylation sites from CID data and to assign associated confidence scores. We present…”
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Large Scale Localization of Protein Phosphorylation by Use of Electron Capture Dissociation Mass Spectrometry by Sweet, Steve M M, Bailey, Christopher M, Cunningham, Debbie L, Heath, John K, Cooper, Helen J

“…We used on-line electron capture dissociation (ECD) for the large scale identification and localization of sites of phosphorylation. Each FT-ICR ECD event was…”
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Quantitative Phosphoproteomics Reveals a Role for Collapsin Response Mediator Protein 2 in PDGF-Induced Cell Migration by Sarhan, Adil R., Szyroka, Justyna, Begum, Shabana, Tomlinson, Michael G., Hotchin, Neil A., Heath, John K., Cunningham, Debbie L.

“…The Platelet Derived Growth Factor (PDGF) family of ligands have well established functions in the induction of cell proliferation and migration during…”
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Novel binding partners and differentially regulated phosphorylation sites clarify Eps8 as a multi-functional adaptor by Cunningham, Debbie L, Creese, Andrew J, Auciello, Giulio, Sweet, Steve M M, Tatar, Tulin, Rappoport, Joshua Z, Grant, Melissa M, Heath, John K

“…Eps8 is involved in both cell signalling and receptor trafficking. It is a known phosphorylation substrate for two proteins involved in the fibroblast growth…”
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FAIMS Enhances the Detection of PTM Crosstalk Sites by Adoni, Kish R, Cunningham, Debbie L, Heath, John K, Leney, Aneika C

“…Protein post-translational modifications (PTMs) enable cells to rapidly change in response to biological stimuli. With hundreds of different PTMs,…”
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Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8 by Auciello, Giulio, Cunningham, Debbie L, Tatar, Tulin, Heath, John K, Rappoport, Joshua Z

“…Fibroblast growth factor receptors (FGFRs) mediate a wide spectrum of cellular responses that are crucial for development and wound healing. However, aberrant…”
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The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome by Jones, Sylwia, Cunningham, Debbie L, Rappoport, Joshua Z, Heath, John K

“…Growth factor signalling regulates multiple cellular functions and its misregulation has been linked to the development and progression of cancer. Ack1…”
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FAIMS and Phosphoproteomics of Fibroblast Growth Factor Signaling: Enhanced Identification of Multiply Phosphorylated Peptides by Zhao, Hongyan, Cunningham, Debbie L, Creese, Andrew J, Heath, John K, Cooper, Helen J

“…We have applied liquid chromatography high-field asymmetric waveform ion mobility spectrometry tandem mass spectrometry (LC–FAIMS–MS/MS) and liquid…”
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Differential responses to kinase inhibition in FGFR2-addicted triple negative breast cancer cells: a quantitative phosphoproteomics study by Cunningham, Debbie L., Sarhan, Adil R., Creese, Andrew J., Larkins, Katherine P. B., Zhao, Hongyan, Ferguson, Harriet R., Brookes, Katie, Marusiak, Anna A., Cooper, Helen J., Heath, John K.

“…Fibroblast Growth Factor (FGF) dependent signalling is frequently activated in cancer by a variety of different mechanisms. However, the downstream signal…”
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Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells by Schoenherr, Christina, Serrels, Bryan, Proby, Charlotte, Cunningham, Debbie L, Findlay, Jane E, Baillie, George S, Heath, John K, Frame, Margaret C

“…Eps8 is an actin regulatory scaffold protein whose expression is increased in squamous cell carcinoma (SCC) cells. It forms a complex with both focal adhesion…”
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Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study by Sarhan, Adil R., Patel, Trushar R., Creese, Andrew J., Tomlinson, Michael G., Hellberg, Carina, Heath, John K., Hotchin, Neil A., Cunningham, Debbie L.

“…Intracellular signaling pathways are reliant on protein phosphorylation events that are controlled by a balance of kinase and phosphatase activity. Although…”
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Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5 by Gilbert, Andrew S, Seoane, Paula I, Sephton-Clark, Poppy, Bojarczuk, Aleksandra, Hotham, Richard, Giurisato, Emanuele, Sarhan, Adil R, Hillen, Amy, Velde, Greetje Vande, Gray, Nathanael S, Alessi, Dario R, Cunningham, Debbie L, Tournier, Cathy, Johnston, Simon A, May, Robin C

“…Vomocytosis, or nonlytic extrusion, is a poorly understood process through which macrophages release live pathogens that they have failed to kill back into the…”
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Differential Phosphoproteomics of Fibroblast Growth Factor Signaling: Identification of Src Family Kinase-Mediated Phosphorylation Events by Cunningham, Debbie L, Sweet, Steve M. M, Cooper, Helen J, Heath, John K

“…Activation of signal transduction by the receptor tyrosine kinase, fibroblast growth factor receptor (FGFR), results in a cascade of protein−protein…”
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Database Search Strategies for Proteomic Data Sets Generated by Electron Capture Dissociation Mass Spectrometry by Sweet, Steve M. M, Jones, Andrew W, Cunningham, Debbie L, Heath, John K, Creese, Andrew J, Cooper, Helen J

“…Large data sets of electron capture dissociation (ECD) mass spectra from proteomic experiments are rich in information; however, extracting that information in…”
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The non-receptor tyrosine kinase Ack1 regulates activated EGFR fate by inducing trafficking to the p62/NBR1 pre-autophagosome by Jones, Sylwia, Cunningham, Debbie L., Rappoport, Joshua Z., Heath, John K.

“…Growth factor signalling regulates multiple cellular functions and its misregulation has been linked to cancer development and progression. Ack1 (Activated…”
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Epidermal Growth Factor Receptor substrate 8 (Eps8) controls Src/FAK-dependent phenotypes in squamous carcinoma cells by Schoenherr, Christina, Serrels, Bryan, Proby, Charlotte, Cunningham, Debbie L., Findlay, Jane E., Baillie, George S., Heath, John K., Frame, Margaret C.

“…Eps8 is an actin regulatory scaffold protein increased in Squamous Cell Carcinoma (SCC) cells. It forms a complex with both Focal Adhesion Kinase (FAK) and…”
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Large Scale Localization of Protein Phosphorylation by Use of Electron Capture Dissociation Mass Spectrometry S by Sweet, Steve. M.M, Bailey, Christopher M., Cunningham, Debbie L., Heath, John K., Cooper, Helen J.

“…We used on-line electron capture dissociation (ECD) for the large scale identification and localization of sites of phosphorylation. Each FT-ICR ECD event was…”
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