Search Results - "Cunnane, S."

A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease by Croteau, E., Castellano, C.A., Fortier, M., Bocti, C., Fulop, T., Paquet, N., Cunnane, S.C.

“…Deteriorating brain glucose metabolism precedes the clinical onset of Alzheimer's disease (AD) and appears to contribute to its etiology. Ketone bodies, mainly…”
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Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele by Chouinard-Watkins, R., Rioux-Perreault, C., Fortier, M., Tremblay-Mercier, J., Zhang, Y., Lawrence, P., Vohl, M. C., Perron, P., Lorrain, D., Brenna, J. T., Cunnane, S. C., Plourde, M.

“…Carrying the apoE ε4 allele (E4+) is the most important genetic risk for Alzheimer's disease. Unlike non-carriers (E4 − ), E4+ seem not to be protected against…”
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Exploratory study of the effect of brain tumors on the default mode network by Ghumman, Sukhmanjit, Fortin, D., Noel-Lamy, M., Cunnane, S. C., Whittingstall, K.

“…Resting state functional magnetic resonance imaging (RS-fMRI) is a popular method of visualizing functional networks in the brain. One of these networks, the…”
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Fish, docosahexaenoic acid and Alzheimer’s disease by Cunnane, S.C., Plourde, M., Pifferi, F., Bégin, M., Féart, C., Barberger-Gateau, P.

“…Cognitive decline in the elderly, particularly Alzheimer’s disease (AD), is a major socio-economic and healthcare concern. We review here the literature on one…”
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From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation by Fulop, T., Dupuis, G., Baehl, S., Le Page, A., Bourgade, K., Frost, E., Witkowski, J. M., Pawelec, G., Larbi, A., Cunnane, S.

“…Aging is accompanied by many physiological changes including those in the immune system. These changes are designated as immunosenescence indicating that age…”
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Linoleic acid recommendations—A house of cards by Cunnane, S.C, Guesnet, P

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Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet by FRASER, D. D, WHITING, S, ANDREW, R. D, MACDONALD, E. A, MUSA-VELOSO, K, CUNNANE, S. C

“…The authors analyzed blood metabolites in nine children with epilepsy prior to starting the ketogenic diet (KD) and 3 to 4 weeks after KD therapy. Elevated…”
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α -Linolenate reduces the dietary requirement for linoleate in the growing rat by Guesnet, P, Lallemand, S.-M, Alessandri, J.-M, Jouin, M, Cunnane, S.C

“…Abstract Background : We hypothesized that due to the absence of a dietary source of omega-3 fatty acids, the essential fatty acid (EFA) deficiency model leads…”
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Brain and systemic glucose metabolism in the healthy elderly following fish oil supplementation by Nugent, S, Croteau, E, Pifferi, F, Fortier, M, Tremblay, S, Turcotte, E, Cunnane, S.C

“…Abstract Cerebral metabolic rate of glucose (CMRg) is lower in individuals affected by cognitive decline and dementia, especially in Alzheimer's disease…”
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Relationship of metabolic and endocrine parameters to brain glucose metabolism in older adults: do cognitively-normal older adults have a particular metabolic phenotype? by Nugent, S., Castellano, C. A., Bocti, C., Dionne, I., Fulop, T., Cunnane, S. C.

“…Our primary objective in this study was to quantify whole brain and regional cerebral metabolic rates of glucose (CMRg) in young and older adults in order to…”
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Impaired Plasma Nonesterified Fatty Acid Tolerance Is an Early Defect in the Natural History of Type 2 Diabetes by Brassard, P., Frisch, F., Lavoie, F., Cyr, D., Bourbonnais, A., Cunnane, S. C., Patterson, B. W., Drouin, R., Baillargeon, J.-P., Carpentier, A. C.

“…Context: Abnormal plasma nonesterified fatty acid (NEFA) metabolism may play a role in the development of type 2 diabetes. Objectives: Our objectives were to…”
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The potential role for arachidonic and docosahexaenoic acids in protection against some central nervous system injuries in preterm infants by Crawford, M. A., Golfetto, I., Ghebremeskel, K., Min, Y., Moodley, T., Poston, L., Phylactos, A., Cunnane, S., Schmidt, W.

“…The risk of central nervous, visual, and auditory damage increases from 2/1000 live births in the normal birthweight to >200/1000 as birthweight falls below…”
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Metabolic response to a ketogenic breakfast in the healthy elderly by Freemantle, E., Vandal, M., Tremblay-Mercier, J., Plourde, M., Poirier, J., Cunnane, S. C.

“…Objective To determine whether the metabolism of glucose or ketones differs in the healthy elderly compared to young or middle-aged adults during mild,…”
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Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: Higher fish intake or aging-related change in n-3 fatty acid metabolism? by Fortier, M, Tremblay-Mercier, J, Plourde, M, Chouinard-Watkins, R, Vandal, M, Pifferi, F, Freemantle, E, Cunnane, S.C

“…Abstract The elderly reportedly have a significantly higher % of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids in plasma and red cell lipids. However,…”
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Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain by Crawford, M. A., Bloom, M., Broadhurst, C. L., Schmidt, W. F., Cunnane, S. C., Galli, C., Gehbremeskel, K., Linseisen, F., Lloyd‐Smith, J., Parkington, J.

“…The African savanna ecosystem of the large mammals and primates was associated with a dramatic decline in relative brain capacity associated with little…”
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Brain fuel uptake during aging and in Alzheimer's disease: A positron emission tomography and MRI study comparing glucose and a new ketone tracer – 11C-acetoacetate by Castellano, C. A., Nugent, S., Tremblay, S., Turcotte, E., Fulop, T., Cunnane, S. C.

“…Lower regional cerebral metabolic rate of glucose (CMRg) is present during normal aging and may contribute to the development or progression of Alzheimer's…”
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Health aspects of partially defatted flaxseed, including effects on serum lipids, oxidative measures, and ex vivo androgen and progestin activity: a controlled crossover trial by Jenkins, D.J.A, Kendall, C.W.C, Vidgen, E, Agarwal, S, Rao, A.V, Rosenberg, R.S, Diamandis, E.P, Novokmet, R, Mehling, C.C, Perera, T, Griffin, L.C

“…Background: Currently there is considerable interest in the potential health benefits of oil seeds, such as soy and flaxseed, especially in relation to…”
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Rift Valley lake fish and shellfish provided brain-specific nutrition for early Homo by Broadhurst, C. Leigh, Cunnane, Stephen C., Crawford, Michael A.

“…An abundant, balanced dietary intake of long-chain polyunsaturated fatty acids is an absolute requirement for sustaining the very rapid expansion of the…”
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Potential role of polyunsaturates in seizure protection achieved with the ketogenic diet by Cunnane, S.C., Musa, K., Ryan, M.A., Whiting, S., Fraser, D.D.

“…Epilepsy is a serious neurological disease that responds to two very different treatments involving lipids. Clinically, it responds to a state of ketosis…”
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The conditional nature of the dietary need for polyunsaturates: a proposal to reclassify ‘essential fatty acids’ as ‘conditionally-indispensable’ or ‘conditionally-dispensable’ fatty acids by Cunnane, Stephen C.

“…The term essential fatty acid no longer clearly identifies the fatty acids it was originally used to describe. It would be more informative if the concept of…”
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