Search Results - "Cuneo, Kyle C."

High-Performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Exosome Metabolomics by Luo, Xian, An, Mingrui, Cuneo, Kyle C, Lubman, David M, Li, Liang

“…Circulating exosomes in bodily fluids such as blood are being actively studied as a rich source of chemical biomarkers for cancer diagnosis and monitoring…”
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Stereotactic Body Radiation Therapy as an Alternative to Transarterial Chemoembolization for Hepatocellular Carcinoma by Sapir, Eli, Tao, Yebin, Schipper, Matthew J., Bazzi, Latifa, Novelli, Paula M., Devlin, Pauline, Owen, Dawn, Cuneo, Kyle C., Lawrence, Theodore S., Parikh, Neehar D., Feng, Mary

“…To conduct a large single-institution comparison of transarterial chemoembolization (TACE) and stereotactic body radiation therapy (SBRT) outcomes in similar…”
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PD-L1 Expression in Circulating Tumor Cells Increases during Radio(chemo)therapy and Indicates Poor Prognosis in Non-small Cell Lung Cancer by Wang, Yang, Kim, Tae Hyun, Fouladdel, Shamileh, Zhang, Zhuo, Soni, Payal, Qin, Angel, Zhao, Lili, Azizi, Ebrahim, Lawrence, Theodore S., Ramnath, Nithya, Cuneo, Kyle C., Nagrath, Sunitha

“…Preclinical studies demonstrated that radiation up-regulates PD-L1 expression in tumor cells, providing a rationale for combining PD-1/PD-L1 inhibitors with…”
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Comparison of Stereotactic Body Radiation Therapy and Radiofrequency Ablation in the Treatment of Intrahepatic Metastases by Jackson, William C., Tao, Yebin, Mendiratta-Lala, Mishal, Bazzi, Latifa, Wahl, Dan R., Schipper, Matthew J., Feng, Mary, Cuneo, Kyle C., Lawrence, Theodore S., Owen, Dawn

“…Stereotactic body radiation therapy (SBRT) and radiofrequency ablation (RFA) are widely used therapies for the treatment of intrahepatic metastases; however,…”
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A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer by Whitley, Melodi Javid, Cardona, Diana M, Lazarides, Alexander L, Spasojevic, Ivan, Ferrer, Jorge M, Cahill, Joan, Lee, Chang-Lung, Snuderl, Matija, Blazer, 3rd, Dan G, Hwang, E Shelley, Greenup, Rachel A, Mosca, Paul J, Mito, Jeffrey K, Cuneo, Kyle C, Larrier, Nicole A, O'Reilly, Erin K, Riedel, Richard F, Eward, William C, Strasfeld, David B, Fukumura, Dai, Jain, Rakesh K, Lee, W David, Griffith, Linda G, Bawendi, Moungi G, Kirsch, David G, Brigman, Brian E

“…Local recurrence is a common cause of treatment failure for patients with solid tumors. Intraoperative detection of microscopic residual cancer in the tumor…”
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EGFR targeted therapies and radiation: Optimizing efficacy by appropriate drug scheduling and patient selection by Cuneo, Kyle C, Nyati, Mukesh K, Ray, Dipankar, Lawrence, Theodore S

“…The epidermal growth factor receptor (EGFR) plays an important role in tumor progression and treatment resistance for many types of malignancies including head…”
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Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress by Cuneo, Kyle C., MD, Morgan, Meredith A., PhD, Davis, Mary A., PhD, Parcels, Leslie A., PhD, Parcels, Joshua, BS, Karnak, David, PhD, Ryan, Caila, Liu, Na, BS, Maybaum, Jonathan, PhD, Lawrence, Theodore S., MD, PhD

“…Purpose Wee1 kinase inhibitors are effective radiosensitizers in cells lacking a G1 checkpoint. In this study we examined the potential effect of Wee1 kinase…”
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Safety and Efficacy of Stereotactic Radiosurgery and Adjuvant Bevacizumab in Patients With Recurrent Malignant Gliomas by Cuneo, Kyle C., M.D, Vredenburgh, James J., M.D, Sampson, John H., M.D., Ph.D, Reardon, David A., M.D, Desjardins, Annick, M.D, Peters, Katherine B., M.D., Ph.D, Friedman, Henry S., M.D, Willett, Christopher G., M.D, Kirkpatrick, John P., M.D., Ph.D

“…Purpose Patients with recurrent malignant gliomas treated with stereotactic radiosurgery (SRS) and multiagent systemic therapies were reviewed to determine the…”
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Modeling of Tumor Control Probability in Stereotactic Body Radiation Therapy for Adrenal Tumors by Stumpf, Priscilla K., Yorke, Ellen D., El Naqa, Issam, Cuneo, Kyle C., Grimm, Jimm, Goodman, Karyn A.

“…Stereotactic body radiation therapy (SBRT) in the management of adrenal metastases is emerging as a well-tolerated, effective method of treatment for patients…”
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Concurrent Stereotactic Radiosurgery and Bevacizumab in Recurrent Malignant Gliomas: A Prospective Trial by Cabrera, Alvin R., MD, Cuneo, Kyle C., MD, Desjardins, Annick, MD, Sampson, John H., MD, PhD, McSherry, Frances, MA, Herndon, James E., PhD, Peters, Katherine B., MD, PhD, Allen, Karen, ANP, Hoang, Jenny K., MBBS, Chang, Zheng, PhD, Craciunescu, Oana, PhD, Vredenburgh, James J., MD, Friedman, Henry S., MD, Kirkpatrick, John P., MD, PhD

“…Purpose Virtually all patients with malignant glioma (MG) eventually recur. This study evaluates the safety of concurrent stereotactic radiosurgery (SRS) and…”
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Is Apparent Diffusion Coefficient Established as an Imaging Biomarker for Stereotactic Body Radiation Therapy Assessment in Hepatocellular Carcinoma? by Cao, Yue, Cuneo, Kyle C., Evans, Joseph, Ten Haken, Randall K., Chang, Daniel T., Lawrence, Theodore S.

“…In this article, as part of this special issue on biomarkers of early response, we review currently available reports regarding magnetic resonance imaging…”
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Circulating Microvesicles from Pancreatic Cancer Accelerate the Migration and Proliferation of PANC‑1 Cells by An, Mingrui, Zhu, Jianhui, Wu, Jing, Cuneo, Kyle C, Lubman, David M

“…Circulating microvesicles are able to mediate long-distance cell–cell communications. It is essential to understand how microvesicles from pancreatic cancer…”
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A human-in-the-loop based Bayesian network approach to improve imbalanced radiation outcomes prediction for hepatocellular cancer patients with stereotactic body radiotherapy by Luo, Yi, Cuneo, Kyle C, Lawrence, Theodore S, Matuszak, Martha M, Dawson, Laura A, Niraula, Dipesh, Ten Haken, Randall K, El Naqa, Issam

“…Imbalanced outcome is one of common characteristics of oncology datasets. Current machine learning approaches have limitation in learning from such datasets…”
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Inducing Oncoprotein Degradation to Improve Targeted Cancer Therapy by Ray, Dipankar, Cuneo, Kyle C, Rehemtulla, Alnawaz, Lawrence, Theodore S, Nyati, Mukesh K

“…Abstract Over the past decade, inhibition of the kinase activities of oncogenic proteins using small molecules and antibodies has been a mainstay of our…”
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Enhancing the Radiation Response in KRAS Mutant Colorectal Cancers Using the c-Met Inhibitor Crizotinib by Cuneo, Kyle C., Mehta, Ranjit K., Kurapati, Himabindu, Thomas, Dafydd G., Lawrence, Theodore S., Nyati, Mukesh K.

“…INTRODUCTION: C-Met plays important roles in treatment resistance, tumor invasion, and metastasis. In this study, we used a small molecule inhibitor of c-Met,…”
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TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy by Cousins, Matthew M., Morris, Emily, Maurino, Christopher, Devasia, Theresa P., Karnak, David, Ray, Dipankar, Parikh, Neehar D., Owen, Dawn, Ten Haken, Randall K., Schipper, Matthew J., Lawrence, Theodore S., Cuneo, Kyle C.

“…•Elevated soluble TNFR1 levels are predictive of liver toxicity among patients receiving radiation.•Soluble TNFR1 levels do not independently predict liver…”
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p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice by Lee, Chang-Lung, Moding, Everett J, Cuneo, Kyle C, Li, Yifan, Sullivan, Julie M, Mao, Lan, Washington, Iman, Jeffords, Laura B, Rodrigues, Rafaela C, Ma, Yan, Das, Shiva, Kontos, Christopher D, Kim, Yongbaek, Rockman, Howard A, Kirsch, David G

“…Radiation therapy, which is used for the treatment of some cancers, can cause delayed heart damage. In the heart, p53 influences myocardial injury that occurs…”
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Serum Levels of Hepatocyte Growth Factor and CD40 Ligand Predict Radiation-Induced Liver Injury by Cuneo, Kyle C., Devasia, Theresa, Sun, Yilun, Schipper, Matthew J., Karnak, David, Davis, Mary A., Owen, Dawn, Feng, Mary, El Naqa, Issam, Bazzi, Latifa, Ten Haken, Randy, Lawrence, Theodore S.

“…BACKGROUND: Declining liver function is a concerning side effect associated with radiation therapy. Biomarkers of liver toxicity would be useful in…”
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Predictors of Acute and Late Toxicity in Patients Receiving Chemoradiation for Unresectable Pancreatic Cancer by Das, Rishi, Hadley, Scott, Sahai, Vaibhav, Bednar, Filip, Evans, Joseph, Lawrence, Theodore, Cuneo, Kyle, Abbott, Madeline R., Schipper, Matt

“…Patients with pancreatic cancer undergoing chemoradiation therapy may experience acute and chronic side effects. We conducted an exploratory analysis of…”
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SU11248 (Sunitinib) Sensitizes Pancreatic Cancer to the Cytotoxic Effects of Ionizing Radiation by Cuneo, Kyle C., M.D, Geng, Ling, M.D, Fu, Allie, B.S, Orton, Darren, Ph.D, Hallahan, Dennis E., M.D, Chakravarthy, Anuradha Bapsi, M.D

“…Purpose SU11248 (sunitinib) is a small-molecule tyrosine kinase inhibitor which targets VEGFR and PDGFR isoforms. In the present study, the effects of SU11248…”
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