Search Results - "Cuneo, J."

The ubiquitin ligase adaptor SPOP in cancer by Cuneo, Matthew J., Mittag, Tanja

“…The dysregulation of ubiquitin‐mediated proteasomal degradation has emerged as an important mechanism of pathogenesis in several cancers. The speckle‐type POZ…”
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Interplay of folded domains and the disordered low-complexity domain in mediating hnRNPA1 phase separation by Martin, Erik W, Thomasen, F Emil, Milkovic, Nicole M, Cuneo, Matthew J, Grace, Christy R, Nourse, Amanda, Lindorff-Larsen, Kresten, Mittag, Tanja

“…Abstract Liquid–liquid phase separation underlies the membrane-less compartmentalization of cells. Intrinsically disordered low-complexity domains (LCDs) often…”
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Capturing snapshots of APE1 processing DNA damage by Freudenthal, Bret D, Beard, William A, Cuneo, Matthew J, Dyrkheeva, Nadezhda S, Wilson, Samuel H

“…New crystal structures of the human endonuclease APE1 bound to substrate and product DNAs reveal the mechanism of recognition and processing of…”
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Mapping periplasmic binding protein oligosaccharide recognition with neutron crystallography by Shukla, Shantanu, Myles, Dean A., Cuneo, Matthew J.

“…Numerous studies have shown how periplasmic binding proteins (PBPs) bind substrates with exquisite specificity, even distinguishing between sugar epimers and…”
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Conformational and oligomeric states of SPOP from small-angle X-ray scattering and molecular dynamics simulations by Thomasen, F Emil, Cuneo, Matthew J, Mittag, Tanja, Lindorff-Larsen, Kresten

“…Speckle-type POZ protein (SPOP) is a substrate adaptor in the ubiquitin proteasome system, and plays important roles in cell-cycle control, development, and…”
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The Macromolecular Neutron Diffractometer MaNDi at the Spallation Neutron Source by Coates, Leighton, Cuneo, Matthew J., Frost, Matthew J., He, Junhong, Weiss, Kevin L., Tomanicek, Stephen J., McFeeters, Hana, Vandavasi, Venu Gopal, Langan, Paul, Iverson, Erik B.

“…The Macromolecular Neutron Diffractometer (MaNDi) is located on beamline 11B of the Spallation Neutron Source at Oak Ridge National Laboratory. The instrument…”
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Differential Substrate Recognition by Maltose Binding Proteins Influenced by Structure and Dynamics by Shukla, Shantanu, Bafna, Khushboo, Gullett, Caeley, Myles, Dean A. A, Agarwal, Pratul K, Cuneo, Matthew J

“…The genome of the hyperthermophile Thermotoga maritima contains three isoforms of maltose binding protein (MBP) that are high-affinity receptors for di-, tri-,…”
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Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase β binding affinity by Cuneo, Matthew J, London, Robert E

“…Formation of a complex between the XRCC1 N-terminal domain (NTD) and DNA polymerase β (Pol β) is central to base excision repair of damaged DNA. Two crystal…”
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Perturbation of bacteriochlorophyll molecules in Fenna–Matthews–Olson protein complexes through mutagenesis of cysteine residues by Saer, Rafael, Orf, Gregory S., Lu, Xun, Zhang, Hao, Cuneo, Matthew J., Myles, Dean A.A., Blankenship, Robert E.

“…The Fenna–Matthews–Olson (FMO) pigment–protein complex in green sulfur bacteria transfers excitation energy from the chlorosome antenna complex to the reaction…”
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Feasibility and Acceptability of Mindfulness-based Stress Reduction and Prenatal Sleep Classes for Poor Prenatal Sleep Quality: Pilot Randomized Controlled Trial by Felder, J. N., Mirchandaney, R., Manber, R., Cuneo, J., Krystal, A., Solomon, N., Janette, S., Zhang, L., Moran, P, Mashash, M., Epel, E, Hecht, F. M

“…The main objectives of the current paper were to examine the feasibility, acceptability, and adherence of a remotely delivered intervention consisting of…”
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A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad by Kumar, Prashasti, Serpersu, Engin H, Cuneo, Matthew J

“…One group of enzymes that confer resistance to aminoglycoside antibiotics through covalent modification belongs to the GCN5-related -acetyltransferase (GNAT)…”
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Programmable ligand detection system in plants through a synthetic signal transduction pathway by Antunes, Mauricio S, Morey, Kevin J, Smith, J Jeff, Albrecht, Kirk D, Bowen, Tessa A, Zdunek, Jeffrey K, Troupe, Jared F, Cuneo, Matthew J, Webb, Colleen T, Hellinga, Homme W, Medford, June I

“…There is an unmet need to monitor human and natural environments for substances that are intentionally or unintentionally introduced. A long-sought goal is to…”
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De novo design of a homo-trimeric amantadine-binding protein by Park, Jooyoung, Selvaraj, Brinda, McShan, Andrew C, Boyken, Scott E, Wei, Kathy Y, Oberdorfer, Gustav, DeGrado, William, Sgourakis, Nikolaos G, Cuneo, Matthew J, Myles, Dean Aa, Baker, David

“…The computational design of a symmetric protein homo-oligomer that binds a symmetry-matched small molecule larger than a metal ion has not yet been achieved…”
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Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation by Zheng, Xunhai, Pedersen, Lars C., Gabel, Scott A., Mueller, Geoffrey A., Cuneo, Matthew J., DeRose, Eugene F., Krahn, Juno M., London, Robert E.

“…HIV-1 reverse transcriptase (RT), a critical enzyme of the HIV life cycle and an important drug target, undergoes complex and largely uncharacterized…”
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The Neutron Macromolecular Crystallography Instruments at Oak Ridge National Laboratory: Advances, Challenges, and Opportunities by Meilleur, Flora, Coates, Leighton, Cuneo, Matthew, Kovalevsky, Andrey, Myles, Dean

“…The IMAGINE and MaNDi instruments, located at Oak Ridge National Laboratory High Flux Isotope Reactor and Spallation Neutron Source, respectively, are powerful…”
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Acceptance and commitment therapy as an adjunct to the MOVE! programme: a randomized controlled trial by Afari, N., Herbert, M. S., Godfrey, K. M., Cuneo, J. G., Salamat, J. S., Mostoufi, S., Gasperi, M., Ober, K., Backhaus, A., Rutledge, T., Wetherell, J. L.

“…Summary Objective The current study tested the efficacy of an acceptance and commitment therapy (ACT) group intervention for disinhibited eating behaviour as…”
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Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses by Horton, Julie K., Stefanick, Donna F., Gassman, Natalie R., Williams, Jason G., Gabel, Scott A., Cuneo, Matthew J., Prasad, Rajendra, Kedar, Padmini S., DeRose, Eugene F., Hou, Esther W., London, Robert E., Wilson, Samuel H.

“…•C12–C20 oxidized and reduced forms of XRCC1 were verified in mouse fibroblasts.•Pol β binding affinity to the XRCC1 NTD decreased with the reduced C12A…”
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Structural Analysis of Semi-specific Oligosaccharide Recognition by a Cellulose-binding Protein of Thermotoga maritima Reveals Adaptations for Functional Diversification of the Oligopeptide Periplasmic Binding Protein Fold by Cuneo, Matthew J., Beese, Lorena S., Hellinga, Homme W.

“…Periplasmic binding proteins (PBPs) constitute a protein superfamily that binds a wide variety of ligands. In prokaryotes, PBPs function as receptors for…”
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Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates by Rizk, Shahir S., Cuneo, Matthew J., Hellinga, Homme W.

“…The Escherichia coli phnD gene is hypothesized to code for the periplasmic binding component of a phosphonate uptake system. Here we report the…”
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Oncogenic signaling of RTK fusions becomes more granular by Cuneo, Matthew J., Mittag, Tanja

“…A spectrum of cancers arises from chromosomal translocations that fuse receptor tyrosine kinase domains to oligomerization domains from unrelated proteins…”
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