Search Results - "Cundiff, Judy K"

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress by Teske, Brian F, Wek, Sheree A, Bunpo, Piyawan, Cundiff, Judy K, McClintick, Jeanette N, Anthony, Tracy G, Wek, Ronald C

“…Disruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER stress and elicit an unfolded protein response (UPR) that involves…”
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GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase by Bunpo, Piyawan, Dudley, Allison, Cundiff, Judy K., Cavener, Douglas R., Wek, Ronald C., Anthony, Tracy G.

“…Asparaginase depletes circulating asparagine and glutamine, activating amino acid deprivation responses (AADR) such as phosphorylation of eukaryotic initiation…”
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The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase by Bunpo, Piyawan, Cundiff, Judy K, Reinert, Rachel B, Wek, Ronald C, Aldrich, Carla J, Anthony, Tracy G

“…Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eukaryotic initiation factor 2 (eIF2) by general control nonderepressible 2 (GCN2)…”
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General Control Nonderepressible 2 (GCN2) Kinase Protects Oligodendrocytes and White Matter during Branched-chain Amino Acid Deficiency in Mice by She, Pengxiang, Bunpo, Piyawan, Cundiff, Judy K., Wek, Ronald C., Harris, Robert A., Anthony, Tracy G.

“…Branched-chain amino acid (BCAA) catabolism is regulated by branched-chain α-keto acid dehydrogenase, an enzyme complex that is inhibited when phosphorylated…”
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Quantitative Analysis of the Human Milk Whey Proteome Reveals Developing Milk and Mammary-Gland Functions across the First Year of Lactation by Zhang, Qiang, Cundiff, Judy K, Maria, Sarah D, McMahon, Robert J, Woo, Jessica G, Davidson, Barbara S, Morrow, Ardythe L

“…In-depth understanding of the changing functions of human milk (HM) proteins and the corresponding physiological adaptions of the lactating mammary gland has…”
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The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment by Wilson, Gabriel J, Bunpo, Piyawan, Cundiff, Judy K, Wek, Ronald C, Anthony, Tracy G

“…Asparaginase is an important drug in the treatment regimen for acute lymphoblastic leukemia. Asparaginase depletes circulating asparagine and glutamine,…”
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Differential Digestion of Human Milk Proteins in a Simulated Stomach Model by Zhang, Qiang, Cundiff, Judy K, Maria, Sarah D, McMahon, Robert J, Wickham, Martin S. J, Faulks, Richard M, van Tol, Eric A. F

“…A key element in understanding how human milk proteins support the health and development of the neonate is to understand how individual proteins are affected…”
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Sensing Small Changes in Protein Abundance: Stimulation of Caco‑2 Cells by Human Whey Proteins by Cundiff, Judy K, McConnell, Elizabeth J, Lohe, Kimberly J, Maria, Sarah D, McMahon, Robert J, Zhang, Qiang

“…Mass spectrometry (MS)-based proteomic approaches have largely facilitated our systemic understanding of cellular processes and biological functions. Cutoffs…”
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Anti-STAT6 CTL activity in Stat6−/− mice: A cautionary tale by Kaplan, Mark H., Cundiff, Judy K., Smith, Jill Stader, Aldrich, Carla J.

“…The generation of germline gene mutations in mice has been an invaluable tool for experimental biology. However, studying immune responses that develop in the…”
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Time‐resolved quantitative analysis of human milk proteome reveals developing milk and mammary‐gland functions during the first year of lactation by Zhang, Qiang, Cundiff, Judy K, Maria, Sarah D, McMahon, Robert J, Woo, Jessica G, Davidson, Barbara S, Morrow, Ardythe L

“…Abstract only In‐depth understanding of the developing function of human milk (HM) proteins and the corresponding physiological adaptions of the lactating…”
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GCN2 is Essential for Oligodendrocyte Development and Myelination in the Brains of Mice Born Deficient in Branched‐Chain α‐Ketoacid Dehydrogenase Kinase (BDK) by Anthony, Tracy G, Bunpo, Piyawan, Cundiff, Judy K, Harris, Robert A, Wek, Ronald C

“…The eukaryotic initiation factor 2 (eIF2) kinase, GCN2, is critical for surviving branched chain amino acid deficiency during early postnatal life. Mice…”
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High Fat Diet Feeding Impairs Lactogenesis and Butyrophilin Expression in the Mammary Gland of Mice by Anthony, Tracy G, Cundiff, Judy K, Lohe, Kim, Parsons, Cathy, Mather, Ian H, Akers, R Michael

“…Overfeeding and obesity negatively impacts milk production in animals, but the underlying mechanisms are unknown. To address this, female C57BL/6J mice were…”
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Signaling Downstream of Mammalian Target of Rapamycin Complex 1 (mTORC1) is Derepressed Following Treatment with L‐Asparaginase in the Liver of GCN2 Knockout Mice by Bunpo, Piyawan, Dudley, Allison, Cundiff, Judy K, Anthony, Tracy G

“…Abstract only Asparaginase reduces liver protein synthesis by increasing the phosphorylation of eukaryotic initiation factor 2 (p‐eIF2) and inhibiting…”
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GCN2 is Essential for the Survival of Mice Born Deficient in Branched‐Chain alpha‐Ketoacid Dehydrogenase Kinase (BDK) by Bunpo, Piyawan, Cundiff, Judy K, Stoltz, Aaron, Wek, Ronald C, Harris, Robert A, Anthony, Tracy G

“…Abstract only The branched‐chain alpha‐keto acid dehydrogenase enzyme complex catalyzes the irreversible catabolism of the branched‐chain amino acids (BCAA)…”
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Immune development in mice fed diets complete in amino acids or lacking the essential amino acid (EAA) leucine is regulated by the eIF2 kinase GCN2 by Aldrich, Carla J, Cundiff, Judy K, Beane, Joal D, Aakhus, Erin O, Heo, Yongjun, Venard, Jacob M, McDaniel, Brent J, Bunpo, Piyawan, Seetharamaiah, G S, McGrath, Barbara, Cavener, Douglas R, Anthony, Tracy G

“…Dietary deprivation of EAA results in reduced mRNA translation and repression of global protein synthesis. In liver this is regulated in part by GCN2…”
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