Search Results - "Cunden, Lisa S"

A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency by Richardson, Christopher E. R, Cunden, Lisa S, Butty, Vincent L, Nolan, Elizabeth M, Lippard, Stephen J, Shoulders, Matthew D

“…We describe the preparation, evaluation, and application of an S100A12 protein-conjugated solid support, hereafter the “A12-resin”, that can remove 99% of…”
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Calcium Ions Tune the Zinc-Sequestering Properties and Antimicrobial Activity of Human S100A12 by Cunden, Lisa S, Gaillard, Aleth, Nolan, Elizabeth M

“…Human S100A12 is a host-defense protein expressed and released by neutrophils that contributes to innate immunity. Apo S100A12 is a 21-kDa antiparallel…”
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Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins by Cunden, Lisa S, Nolan, Elizabeth M

“…The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn­(II)-sequestering…”
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High-Affinity Manganese Coordination by Human Calprotectin Is Calcium-Dependent and Requires the Histidine-Rich Site Formed at the Dimer Interface by Hayden, Joshua A, Brophy, Megan Brunjes, Cunden, Lisa S, Nolan, Elizabeth M

“…Calprotectin (CP) is a transition metal-chelating antimicrobial protein of the calcium-binding S100 family that is produced and released by neutrophils. It…”
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Biochemical and Functional Evaluation of the Intramolecular Disulfide Bonds in the Zinc-Chelating Antimicrobial Protein Human S100A7 (Psoriasin) by Cunden, Lisa S, Brophy, Megan Brunjes, Rodriguez, Grayson E, Flaxman, Hope A, Nolan, Elizabeth M

“…Human S100A7 (psoriasin) is a metal-chelating protein expressed by epithelial cells. It is a 22-kDa homodimer with two EF-hand domains per subunit and two…”
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The Hexahistidine Motif of Host-Defense Protein Human Calprotectin Contributes to Zinc Withholding and Its Functional Versatility by Nakashige, Toshiki G, Stephan, Jules R, Cunden, Lisa S, Brophy, Megan Brunjes, Wommack, Andrew J, Keegan, Brenna C, Shearer, Jason M, Nolan, Elizabeth M

“…Human calprotectin (CP, S100A8/S100A9 oligomer, MRP-8/MRP-14 oligomer) is an abundant host-defense protein that is involved in the metal-withholding innate…”
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Fe(CO)4 and Related Compounds as Isolobal Fragments by Cunden, Lisa S, Linck, R. G

“…The M(CO)4 fragment can be assigned to be isolobal with both CH3 + and CH2. In order to investigate this ambiguous isolobal assignment, we report calculations…”
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Calcium ions tune the zinc-sequestering properties and antimicrobial activity of human S100A12Electronic supplementary information (ESI) available: Complete experimental methods, Tables S1-S14 and Fig. S1-S10. See DOI: 10.1039/c5sc03655k by Cunden, Lisa S, Gaillard, Aleth, Nolan, Elizabeth M

“…Human S100A12 is a host-defense protein expressed and released by neutrophils that contributes to innate immunity. Apo S100A12 is a 21 kDa antiparallel…”
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Calcium ions tune the zinc-sequestering properties and antimicrobial activity of human S100A12† †Electronic supplementary information (ESI) available: Complete experimental methods, Tables S1–S14 and Fig. S1–S10. See DOI: 10.1039/c5sc03655k by Cunden, Lisa S., Gaillard, Aleth, Nolan, Elizabeth M.

“…Human S100A12 exhibits Ca( ii )-dependent Zn( ii )-binding properties and antifungal activity. Human S100A12 is a host-defense protein expressed and released…”
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152. rapid Ultra-high Enrichment of Bacterial Pathogens at Low Concentration from Blood for Species ID and AMR Prediction Using Nanopore Sequencing by Tsui, Chiahao, Cunden, Lisa S, Billings, Nicole, Nanayakkara, Imaly A, Herriott, Ian, Kumcu, Michael E, Martin, Rachel R, Chen, Michelle, Pangestu, Febriana, Knysh, Paul, Maddux, Cabell, Munro, Zachary, Huntley, Miriam

“…Abstract Background Each year in the United States there are over 1.7 million cases of sepsis that account for a third of hospital deaths. A key to reducing…”
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153. pilot Study of a Novel Whole-genome Sequencing Based Rapid Bacterial Identification Assay in Patients with Bacteremia by Asundi, Archana, Billings, Nicole, Rogers, Zoe H, Roche, Samantha, Bombard, Jennifer, Kumcu, Michael E, Cunden, Lisa S, Nanayakkara, Imaly A, Tsui, Chiahao, Knysh, Paul, Maddux, Cabell, Munro, Zachary, Herriott, Ian, Huntley, Miriam, Lin, Nina H

“…Abstract Background Blood stream infections (BSI) are among the leading cause of morbidity and mortality, yet gold standard culture-based diagnostics have…”
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