Search Results - "Cundell, Michael J"
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BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation
Published in Molecular cell (07-11-2013)“…Cytokinesis follows separase activation and chromosome segregation. This order is ensured in budding yeast by the mitotic exit network (MEN), where Cdc14p…”
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A PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit
Published in The Journal of cell biology (29-08-2016)“…PP2A-B55 is one of the major phosphatases regulating cell division. Despite its importance for temporal control during mitotic exit, how B55 substrates are…”
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KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle
Published in The Journal of cell biology (22-12-2014)“…The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B…”
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CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization
Published in The Journal of cell biology (01-04-2019)“…Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a…”
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Functional specialisation of yeast Rho1 GTP exchange factors
Published in Journal of cell science (01-06-2012)“…Rho GTPases are regulated in complex spatiotemporal patterns that might be dependent, in part at least, on the multiplicity of their GTP exchange factors…”
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