Search Results - "Cummons, Terri A."

The persistence of a long-term negative affective state following the induction of either acute or chronic pain by Hummel, Michele, Lu, Peimin, Cummons, Terri A., Whiteside, Garth T.

“…Clinically, pain is a complex phenomenon consisting of both sensory and affective aberrations that can persist indefinitely. Pre-clinically, several animal…”
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Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity by Brandt, Michael R, Cummons, Terri A, Potestio, Lisa, Sukoff, Stacey J, Rosenzweig-Lipson, Sharon

“…Perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] is a selective, competitive N-methyl-D-aspartate (NMDA)…”
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An estrogen receptor-β agonist is active in models of inflammatory and chemical-induced pain by Leventhal, Liza, Brandt, Michael R., Cummons, Terri A., Piesla, Michael J., Rogers, Kathryn E., Harris, Heather A.

“…ERB-041 (2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3 benzoxazol-5-ol) is a selective estrogen receptor-β agonist with activity in rodent models of rheumatoid…”
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Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain by Sullivan, Nicole R, Leventhal, Liza, Harrison, James, Smith, Valerie A, Cummons, Terri A, Spangler, Taylor B, Sun, Shaiu-Ching, Lu, Peimin, Uveges, Albert J, Strassle, Brian W, Piesla, Michael J, Ramdass, Rana, Barry, Alena, Schantz, Jonathan, Adams, William, Whiteside, Garth T, Adedoyin, Adedayo, Jones, Philip G

“…Here, we have investigated the in vitro pharmacology of a muscarinic agonist, (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane…”
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Abnormal gait, due to inflammation but not nerve injury, reflects enhanced nociception in preclinical pain models by Piesla, Michael J, Leventhal, Liza, Strassle, Brian W, Harrison, James E, Cummons, Terri A, Lu, Peimin, Whiteside, Garth T

“…Abstract Validation of gait analysis has the potential to bridge the gap between data from animal pain models and clinical observations. The goal of these…”
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Prodrugs of Perzinfotel with Improved Oral Bioavailability by Baudy, Reinhardt B, Butera, John A, Abou-Gharbia, Magid A, Chen, Hong, Harrison, Boyd, Jain, Uday, Magolda, Ronald, Sze, Jean Y, Brandt, Michael R, Cummons, Terri A, Kowal, Diane, Pangalos, Menelas N, Zupan, Bojana, Hoffmann, Matthew, May, Michael, Mugford, Cheryl, Kennedy, Jeffrey, Childers, Wayne E

“…Previous studies with perzinfotel (1), a potent, selective, competitive NMDA receptor antagonist, showed it to be efficacious in inflammatory and neuropathic…”
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