Search Results - "Cummins, Philip M"

Occludin: One Protein, Many Forms by Cummins, Philip M.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The blood-brain barrier endothelium: a target for pro-inflammatory cytokines by Rochfort, Keith D, Cummins, Philip M

“…An intact functioning blood-brain barrier (BBB) is fundamental to proper homoeostatic maintenance and perfusion of the central nervous system (CNS)…”
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Downregulation of blood-brain barrier phenotype by proinflammatory cytokines involves NADPH oxidase-dependent ROS generation: consequences for interendothelial adherens and tight junctions by Rochfort, Keith D, Collins, Laura E, Murphy, Ronan P, Cummins, Philip M

“…Blood-brain barrier (BBB) dysfunction is an integral feature of neurological disorders and involves the action of multiple proinflammatory cytokines on the…”
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Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium by Rochfort, Keith D., Cummins, Philip M.

“…Zonula occludens-1 (ZO-1) is essential to the proper assembly of interendothelial junction complexes that control blood–brain barrier (BBB) integrity. The goal…”
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RANKL promotes osteoblastic activity in vascular smooth muscle cells by upregulating endothelial BMP-2 release by Davenport, Colin, Harper, Emma, Forde, Hannah, Rochfort, Keith D., Murphy, Ronan P., Smith, Diarmuid, Cummins, Philip M.

“…Receptor activator of nuclear factor kappa beta-ligand (RANKL) is thought to promote vascular calcification (VC) by inducing osteoblastic behaviour in vascular…”
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TRAIL attenuates RANKL-mediated osteoblastic signalling in vascular cell mono-culture and co-culture models by Harper, Emma, Rochfort, Keith D, Forde, Hannah, Davenport, Colin, Smith, Diarmuid, Cummins, Philip M

“…Vascular calcification (VC) is a major risk factor for elevated cardiovascular morbidity/mortality. Underlying this process is osteoblastic signalling within…”
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Stabilization of brain microvascular endothelial barrier function by shear stress involves VE-cadherin signaling leading to modulation of pTyr-occludin levels by Walsh, Tony G., Murphy, Ronan P., Fitzpatrick, Paul, Rochfort, Keith D., Guinan, Anthony F., Murphy, Andrew, Cummins, Philip M.

“…Blood–brain barrier (BBB) regulation involves the coordinated interaction of intercellular adherens and tight junctions in response to stimuli. One such…”
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Shear-Dependent Attenuation of Cellular ROS Levels can Suppress Proinflammatory Cytokine Injury to Human Brain Microvascular Endothelial Barrier Properties by Rochfort, Keith D, Collins, Laura E, McLoughlin, Alisha, Cummins, Philip M

“…The regulatory interplay between laminar shear stress and proinflammatory cytokines during homeostatic maintenance of the brain microvascular endothelium is…”
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RANKL Inhibits the Production of Osteoprotegerin from Smooth Muscle Cells under Basal Conditions and following Exposure to Cyclic Strain by Davenport, Colin, Harper, Emma, Rochfort, Keith D, Forde, Hannah, Smith, Diarmuid, Cummins, Philip M

“…Receptor activator of nuclear factor-κB ligand (RANKL) promotes vascular calcification, while osteoprotegerin (OPG) opposes it by blocking RANKL activity. It…”
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Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress by Colgan, Olga C, Ferguson, Gail, Collins, Nora T, Murphy, Ronan P, Meade, Gerardeane, Cahill, Paul A, Cummins, Philip M

“…Blood-brain barrier (BBB) controls paracellular solute diffusion into the brain microenvironment and is maintained primarily by tight junctions between…”
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Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain by Martin, Fiona A, McLoughlin, Alisha, Rochfort, Keith D, Davenport, Colin, Murphy, Ronan P, Cummins, Philip M

“…Thrombomodulin (TM), an integral membrane glycoprotein expressed on the lumenal surface of vascular endothelial cells, promotes anti-coagulant and…”
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TRAIL inhibits oxidative stress in human aortic endothelial cells exposed to pro‐inflammatory stimuli by Forde, Hannah, Harper, Emma, Rochfort, Keith D., Wallace, Robert G., Davenport, Colin, Smith, Diarmuid, Cummins, Philip M.

“…Studies suggest that tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) has vasoprotective potential, as low levels of TRAIL cause accelerated…”
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Cyclic Strain Inhibits Notch Receptor Signaling in Vascular Smooth Muscle Cells In Vitro by Morrow, David, Sweeney, Catherine, Birney, Yvonne A, Cummins, Philip M, Walls, Dermot, Redmond, Eileen M, Cahill, Paul A

“…Notch signaling has been shown recently to regulate vascular cell fate in adult cells. By applying a uniform equibiaxial cyclic strain to vascular smooth…”
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Thrombomodulin and the vascular endothelium: insights into functional, regulatory, and therapeutic aspects by Martin, Fiona A, Murphy, Ronan P, Cummins, Philip M

“…Thrombomodulin (TM) is a 557-amino acid protein with a broad cell and tissue distribution consistent with its wide-ranging physiological roles. When expressed…”
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Tumour necrosis factor‐α‐mediated disruption of cerebrovascular endothelial barrier integrity in vitro involves the production of proinflammatory interleukin‐6 by Rochfort, Keith D., Collins, Laura E., McLoughlin, Alisha, Cummins, Philip M.

“…The co‐involvement of tumour necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6) during blood‐brain barrier (BBB) injury has been reported in various models of…”
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Vascular calcification in type-2 diabetes and cardiovascular disease: Integrative roles for OPG, RANKL and TRAIL by Harper, Emma, Forde, Hannah, Davenport, Colin, Rochfort, Keith D, Smith, Diarmuid, Cummins, Philip M

“…Abstract Vascular calcification (VC), a disorder that causes blood vessel hardening and dysfunction, is a significant risk factor for type-2 diabetes mellitus…”
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Ion-Exchange Chromatography: Basic Principles and Application by Cummins, Philip M, Rochfort, Keith D, O'Connor, Brendan F

“…Ion-Exchange Chromatography (IEC) allows for the separation of ionizable molecules on the basis of differences in charge properties. Its large sample-handling…”
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Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR by Degryse, Bernard, Britto, Mishan, Shan, Chun Xu, Wallace, Robert G., Rochfort, Keith D., Cummins, Philip M., Meade, Gerardene, Murphy, Ronan P.

“…The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections…”
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Helicobacter pylori-induced inhibition of vascular endothelial cell functions: a role for VacA-dependent nitric oxide reduction by Tobin, Nicholas P, Henehan, Gary T, Murphy, Ronan P, Atherton, John C, Guinan, Anthony F, Kerrigan, Steven W, Cox, Dermot, Cahill, Paul A, Cummins, Philip M

“…Epidemiological and clinical studies provide compelling support for a causal relationship between Helicobacter pylori infection and endothelial dysfunction,…”
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RANKL treatment of vascular endothelial cells leading to paracrine pro-calcific signaling involves ROS production by Harper, Emma, Rochfort, Keith D., Smith, Diarmuid, Cummins, Philip M.

“…Numerous studies have highlighted the causal link between over-production of reactive oxygen species (ROS) and cardiovascular complications such as vascular…”
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