Search Results - "Cummings, Christopher F"
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Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture
Published in Cell (05-06-2014)“…Bromine is ubiquitously present in animals as ionic bromide (Br(-)) yet has no known essential function. Herein, we demonstrate that Br(-) is a required…”
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Building collagen IV smart scaffolds on the outside of cells
Published in Protein science (01-11-2017)“…Collagen IV scaffolds assemble through an intricate pathway that begins intracellularly and is completed extracellularly. Multiple intracellular enzymes act in…”
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Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis
Published in Nature chemical biology (01-09-2012)“…Peroxidasin uses hypohalous acid oxidants to catalyze the formation of sulfilimine bonds in basement membranes. Collagen IV comprises the predominant protein…”
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Extracellular chloride signals collagen IV network assembly during basement membrane formation
Published in The Journal of cell biology (23-05-2016)“…Basement membranes are defining features of the cellular microenvironment; however, little is known regarding their assembly outside cells. We report that…”
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Lens capsule as a model to study type IV collagen
Published in Connective tissue research (01-01-2014)“…The study of collagen IV has benefited greatly from the seminal work conducted by Arthur Veis and colleagues over three decades ago. Through a series of…”
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