Search Results - "Culviner, Peter H."

Global Analysis of the E. coli Toxin MazF Reveals Widespread Cleavage of mRNA and the Inhibition of rRNA Maturation and Ribosome Biogenesis by Culviner, Peter H., Laub, Michael T.

“…Toxin-antitoxin systems are widely distributed genetic modules that regulate growth and persistence in bacteria. Many systems, including E. coli MazEF, include…”
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A Simple, Cost-Effective, and Robust Method for rRNA Depletion in RNA-Sequencing Studies by Culviner, Peter H, Guegler, Chantal K, Laub, Michael T

“…The profiling of gene expression by RNA sequencing (RNA-seq) has enabled powerful studies of global transcriptional patterns in all organisms, including…”
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Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis by Bei, Cheng, Zhu, Junhao, Culviner, Peter H., Gan, Mingyu, Rubin, Eric J., Fortune, Sarah M., Gao, Qian, Liu, Qingyun

“…Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to changing environments, yet the concept of transcriptional…”
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Global Analysis of the Specificities and Targets of Endoribonucleases from Escherichia coli Toxin-Antitoxin Systems by Culviner, Peter H, Nocedal, Isabel, Fortune, Sarah M, Laub, Michael T

“…Toxin-antitoxin systems are widely distributed genetic modules typically featuring toxins that can inhibit bacterial growth and antitoxins that can reverse…”
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Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis by Hicks, Nathan D, Giffen, Samantha R, Culviner, Peter H, Chao, Michael C, Dulberger, Charles L, Liu, Qingyun, Stanley, Sydney, Brown, Jessica, Sixsmith, Jaimie, Wolf, Ian D, Fortune, Sarah M

“…Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical…”
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Electrostatic Effect of the Ribosomal Surface on Nascent Polypeptide Dynamics by Knight, Anders M, Culviner, Peter H, Kurt-Yilmaz, Neşe, Zou, Taisong, Ozkan, S. Banu, Cavagnero, Silvia

“…The crucial molecular events accompanying protein folding in the cell are still largely unexplored. As nascent polypeptides emerge from the ribosomal exit…”
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Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin by LeRoux, Michele, Culviner, Peter H., Liu, Yue J., Littlehale, Megan L., Laub, Michael T.

“…Toxin-antitoxin (TA) systems are ubiquitous genetic elements in bacterial genomes, but their functions are controversial. Although they are frequently…”
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An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs by Bullen, Nathan P., Sychantha, David, Thang, Stephanie S., Culviner, Peter H., Rudzite, Marta, Ahmad, Shehryar, Shah, Vraj S., Filloux, Alain, Prehna, Gerd, Whitney, John C.

“…ADP-ribosyltransferases (ARTs) were among the first identified bacterial virulence factors. Canonical ART toxins are delivered into host cells where they…”
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Escherichia coli SymE is a DNA‐binding protein that can condense the nucleoid by Thompson, Mary K., Nocedal, Isabel, Culviner, Peter H., Zhang, Tong, Gozzi, Kevin R., Laub, Michael T.

“…Type I toxin‐antitoxin (TA) systems typically consist of a protein toxin that imbeds in the inner membrane where it can oligomerize and form pores that change…”
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Confined dynamics of a ribosome‐bound nascent globin: Cone angle analysis of fluorescence depolarization decays in the presence of two local motions by Ellis, Jamie P., Culviner, Peter H., Cavagnero, Silvia

“…We still know very little about how proteins achieve their native three‐dimensional structure in vitro and in the cell. Folding studies as proteins emerge from…”
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Production of Ribosome-Released Nascent Proteins with Optimal Physical Properties by Ziehr, David R, Ellis, Jamie P, Culviner, Peter H, Cavagnero, Silvia

“…The growing interest in protein folding under physiologically relevant conditions has prompted investigations requiring direct comparisons between…”
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Confined dynamics of a ribosome‐bound nascent globin: Cone angle analysis of fluorescence depolarization decays in the presence of two local motions by Ellis, Jamie P., Culviner, Peter H., Cavagnero, Silvia

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