Search Results - "Culp‐Hill, Rachel"

Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells by D'Alessandro, Angelo, Reisz, Julie A., Culp‐Hill, Rachel, Korsten, Herbert, van Bruggen, Robin, de Korte, Dirk

“…BACKGROUND Over a century of advancements in the field of additive solutions for red blood cell (RBC) storage has made transfusion therapy a safe and effective…”
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Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells by Reisz, Julie A., Nemkov, Travis, Dzieciatkowska, Monika, Culp‐Hill, Rachel, Stefanoni, Davide, Hill, Ryan C., Yoshida, Tatsuro, Dunham, Andrew, Kanias, Tamir, Dumont, Larry J., Busch, Michael, Eisenmesser, Elan Z., Zimring, James C., Hansen, Kirk C., D'Alessandro, Angelo

“…BACKGROUND Being devoid of de novo protein synthesis capacity, red blood cells (RBCs) have evolved to recycle oxidatively damaged proteins via mechanisms that…”
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Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism by Culp‐Hill, Rachel, Srinivasan, Amudan J., Gehrke, Sarah, Kamyszek, Reed, Ansari, Andrea, Shah, Nirmish, Welsby, Ian, D'Alessandro, Angelo

“…BACKGROUND Exchange transfusion is a mainstay in the treatment of sickle cell anemia. Transfusion recipients with sickle cell disease (SCD) can be transfused…”
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Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III—Omics by D'Alessandro, Angelo, Culp‐Hill, Rachel, Reisz, Julie A., Anderson, Mikayla, Fu, Xiaoyun, Nemkov, Travis, Gehrke, Sarah, Zheng, Connie, Kanias, Tamir, Guo, Yuelong, Page, Grier, Gladwin, Mark T., Kleinman, Steve, Lanteri, Marion, Stone, Mars, Busch, Michael, Zimring, James C.

“…BACKGROUND Biological and technical variability has been increasingly appreciated as a key factor impacting red blood cell (RBC) storability and, potentially,…”
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Short‐term interleukin‐37 treatment improves vascular endothelial function, endurance exercise capacity, and whole‐body glucose metabolism in old mice by Ballak, Dov B., Brunt, Vienna E., Sapinsley, Zachary J., Ziemba, Brian P., Richey, James J., Zigler, Melanie C., Johnson, Lawrence C., Gioscia‐Ryan, Rachel A., Culp‐Hill, Rachel, Eisenmesser, Elan Z., D'Alessandro, Angelo, Dinarello, Charles A., Seals, Douglas R.

“…Aging is associated with vascular endothelial dysfunction, reduced exercise tolerance, and impaired whole‐body glucose metabolism. Interleukin‐37 (IL‐37), an…”
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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells by Jones, Courtney L., Stevens, Brett M., D'Alessandro, Angelo, Reisz, Julie A., Culp-Hill, Rachel, Nemkov, Travis, Pei, Shanshan, Khan, Nabilah, Adane, Biniam, Ye, Haobin, Krug, Anna, Reinhold, Dominik, Smith, Clayton, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.

“…In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem cells to elucidate properties relevant to therapeutic intervention. We…”
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Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II by Jones, Courtney L., Stevens, Brett M., D'Alessandro, Angelo, Culp-Hill, Rachel, Reisz, Julie A., Pei, Shanshan, Gustafson, Annika, Khan, Nabilah, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.

“…We have previously demonstrated that oxidative phosphorylation is required for the survival of human leukemia stem cells (LSCs) from patients with acute…”
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Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity by D'Alessandro, Angelo, Fu, Xiaoyun, Kanias, Tamir, Reisz, Julie A, Culp-Hill, Rachel, Guo, Yuelong, Gladwin, Mark T, Page, Grier, Kleinman, Steven, Lanteri, Marion, Stone, Mars, Busch, Michael P, Zimring, James C

“…Red blood cell storage in the blood bank promotes the progressive accumulation of metabolic alterations that may ultimately impact the erythrocyte capacity to…”
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Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity by Montgomery, Theresa L., Künstner, Axel, Kennedy, Josephine J., Fang, Qian, Asarian, Lori, Culp-Hill, Rachel, D’Alessandro, Angelo, Teuscher, Cory, Busch, Hauke, Krementsov, Dimitry N.

“…Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. The etiology of MS is multifactorial, with disease risk determined by genetics…”
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Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance by Giddings, Emily L., Champagne, Devin P., Wu, Meng-Han, Laffin, Joshua M., Thornton, Tina M., Valenca-Pereira, Felipe, Culp-Hill, Rachel, Fortner, Karen A., Romero, Natalia, East, James, Cao, Phoebe, Arias-Pulido, Hugo, Sidhu, Karatatiwant S., Silverstrim, Brian, Kam, Yoonseok, Kelley, Shana, Pereira, Mark, Bates, Susan E., Bunn, Janice Y., Fiering, Steven N., Matthews, Dwight E., Robey, Robert W., Stich, Domink, D’Alessandro, Angelo, Rincon, Mercedes

“…Chemotherapy remains the standard of care for most cancers worldwide, however development of chemoresistance due to the presence of the drug-effluxing ATP…”
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Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors by Powers, Rani K., Culp-Hill, Rachel, Ludwig, Michael P., Smith, Keith P., Waugh, Katherine A., Minter, Ross, Tuttle, Kathryn D., Lewis, Hannah C., Rachubinski, Angela L., Granrath, Ross E., Carmona-Iragui, María, Wilkerson, Rebecca B., Kahn, Darcy E., Joshi, Molishree, Lleó, Alberto, Blesa, Rafael, Fortea, Juan, D’Alessandro, Angelo, Costello, James C., Sullivan, Kelly D., Espinosa, Joaquin M.

“…Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by ill-defined mechanisms. Here we report a large metabolomics study of…”
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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells by Jones, Courtney L., Stevens, Brett M., D’Alessandro, Angelo, Reisz, Julie A., Culp-Hill, Rachel, Nemkov, Travis, Pei, Shanshan, Khan, Nabilah, Adane, Biniam, Ye, Haobin, Krug, Anna, Reinhold, Dominik, Smith, Clayton, DeGregori, James, Pollyea, Daniel A., Jordan, Craig T.

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Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity by O'Brien, Cristiana, Ling, Tianyi, Berman, Jacob M, Culp-Hill, Rachel, Reisz, Julie A, Rondeau, Vincent, Jahangiri, Soheil, St-Germain, Jonathan, Macwan, Vinitha, Astori, Audrey, Zeng, Andy, Hong, Jun Young, Li, Meng, Yang, Min, Jana, Sadhan, Gamboni, Fabia, Tsao, Emily, Liu, Weiyi, Dick, John E, Lin, Hening, Melnick, Ari, Tikhonova, Anastasia, Arruda, Andrea, Minden, Mark D, Raught, Brian, D'Alessandro, Angelo, Jones, Courtney L

“…Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease initiating…”
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Lysosomal acid lipase A modulates leukemia stem cell response to venetoclax/tyrosine kinase inhibitor combination therapy in blast phase chronic myeloid leukemia by Minhajuddin, Mohd, Winters, Amanda, Ye, Haobin, Pei, Shanshan, Stevens, Brett, Gillen, Austin, Engel, Krysta, Gipson, Stephanie, Ransom, Monica, Amaya, Maria, Inguva, Anagha, Gasparetto, Maura, Althoff, Mark J, Miller, Regan, Shelton, Ian, Tolison, Hunter, Krug, Anna, Culp-Hill, Rachel, D'Alessandro, Angelo, Sherbenou, Daniel W, Pollyea, Daniel A, Smith, Clayton, Jordan, Craig T

“…The treatment of blast phase chronic myeloid leukemia (bpCML) remains a challenge due at least in part to drug resistance of leukemia stem cells (LSCs). Recent…”
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ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota by Eberhart, Tanja, Stanley, Federico Uchenna, Ricci, Luisa, Chirico, Tiziana, Ferrarese, Roberto, Sisti, Sofia, Scagliola, Alessandra, Baj, Andreina, Badurek, Sylvia, Sommer, Andreas, Culp-Hill, Rachel, Dzieciatkowska, Monika, Shokry, Engy, Sumpton, David, D’Alessandro, Angelo, Clementi, Nicola, Mancini, Nicasio, Cardaci, Simone

“…Aconitate decarboxylase 1 (ACOD1) is the enzyme synthesizing itaconate, an immuno-regulatory metabolite tuning host-pathogen interactions. Such functions are…”
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Circadian period 2: a missing beneficial factor in sickle cell disease by lowering pulmonary inflammation, iron overload, and mortality by Adebiyi, Morayo G., Zhao, Zhaoyang, Ye, Youqiong, Manalo, Jeanne, Hong, Yue, Lee, Cheng Chi, Xian, Wa, McKeon, Frank, Culp‐Hill, Rachel, D'Alessandro, Angelo, Kellems, Rodney E., Yoo, Seung‐Hee, Han, Leng, Xia, Yang

“…ABSTRACTThe circadian clock is important for cellular and organ function. However, its function in sickle cell disease (SCD), a life‐threatening hemolytic…”
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The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival Pathways Mediated by LIPG by Ye, Haobin, Minhajuddin, Mohammad, Krug, Anna, Pei, Shanshan, Chou, Chih-Hsing, Culp-Hill, Rachel, Ponder, Jessica, De Bloois, Erik, Schniedewind, Björn, Amaya, Maria L, Inguva, Anagha, Stevens, Brett M, Pollyea, Daniel A, Christians, Uwe, Grimes, H Leighton, D'Alessandro, Angelo, Jordan, Craig T

“…Due to the disseminated nature of leukemia, malignant cells are exposed to many different tissue microenvironments, including a variety of extramedullary…”
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Investigation of the effects of storage and freezing on mixes of heavy‐labeled metabolite and amino acid standards by Culp‐Hill, Rachel, Reisz, Julie A., Hansen, Kirk C., D'Alessandro, Angelo

“…Rationale High‐throughput metabolomics has now made it possible for small/medium‐sized laboratories to analyze thousands of samples/year from the most diverse…”
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Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice by Howie, Heather L., Hay, Ariel M., de Wolski, Karen, Waterman, Hayley, Lebedev, Jenna, Fu, Xiaoyun, Culp-Hill, Rachel, D'Alessandro, Angelo, Gorham, James D., Ranson, Matthew S., Roback, John D., Thomson, Peter C., Zimring, James C.

“…Red blood cells (RBCs) are the most numerous cell type in the body and serve a vital purpose of delivering oxygen to essentially all tissues. In addition to…”
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