Search Results - "Culman, Juraj"

Neuroprotective and antioxidative effects of pioglitazone in brain tissue adjacent to the ischemic core are mediated by PI3K/Akt and Nrf2/ARE pathways by Zhao, Yi, Lützen, Ulf, Gohlke, Peter, Jiang, Ping, Herdegen, Thomas, Culman, Juraj

“…The present study elucidates the neuroprotective mechanisms of the PPARγ (peroxisome proliferator-activated receptor γ) agonist pioglitazone in survival of…”
Get full text

Activation of cerebral peroxisome proliferator‐activated receptors gamma promotes neuroprotection by attenuation of neuronal cyclooxygenase‐2 overexpression after focal cerebral ischemia in rats by Zhao, Yi, Patzer, Andreas, Herdegen, Thomas, Gohlke, Peter, Culman, Juraj

“…ABSTRACT Up‐regulation of cyclooxygenase (COX)‐2 exacerbates neuronal injury after cerebral ischemia and contributes to neuronal cell death. The present study…”
Get full text

Angiotensin AT2 receptor protects against cerebral ischemia-induced neuronal injury by Li, Jun, Culman, Juraj, Hörtnagl, Heide, Zhao, Yi, Gerova, Nadezhda, Timm, Melanie, Blume, Annegret, Zimmermann, Mathias, Seidel, Kerstin, Dirnagl, Ulrich, Unger, Thomas

“…ABSTRACT Several lines of clinical and experimental evidence suggest an important role of the reninangiotensin system in ischemic brain injury although the…”
Get full text

Activation of intracellular angiotensin AT₂ receptors induces rapid cell death in human uterine leiomyosarcoma cells by Zhao, Yi, Lützen, Ulf, Fritsch, Jürgen, Zuhayra, Maaz, Schütze, Stefan, Steckelings, Ulrike M, Recanti, Chiara, Namsoleck, Pawel, Unger, Thomas, Culman, Juraj

“…The presence of angiotensin type 2 (AT₂) receptors in mitochondria and their role in NO generation and cell aging were recently demonstrated in various human…”
Get more information

Biodistribution and pharmacokinetics of the 99mTc labeled human elastase inhibitor, elafin, in rats by Kaschwich, Mark, Lützen, Ulf, Zhao, Yi, Tjiong, Angelina, Marx, Marlies, Haenisch, Sierk, Wiedow, Oliver, Preuss, Stefanie, Culman, Juraj, Zuhayra, Maaz

“…Elafin is a potent reversible inhibitor of the pro-inflammatory proteases leukocyte elastase and protease 3. It is currently in clinical development for the…”
Get full text

Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes by Schmerbach, Kristin, Pfab, Thiemo, Zhao, Yi, Culman, Juraj, Mueller, Susanne, Villringer, Arno, Muller, Dominik N, Hocher, Berthold, Unger, Thomas, Thoene-Reineke, Christa

“…Pre-treatment with angiotensin receptor blockers is known to improve neurological outcome after stroke. This study investigated for the first time, whether the…”
Get full text

Sustained Blockade of Brain AT1 Receptors Before and After Focal Cerebral Ischemia Alleviates Neurologic Deficits and Reduces Neuronal Injury, Apoptosis, and Inflammatory Responses in the Rat by Lou, Min, Blume, Annegret, Zhao, Yi, Gohlke, Peter, Deuschl, Günther, Herdegen, Thomas, Culman, Juraj

“…In the present study, we investigate whether a long-term blockade of brain AT1 receptors in male Wistar rats before and after ischemic injury exerts…”
Get full text

Angiotensin II induces peroxisome proliferator‐activated receptor gamma in PC12W cells via angiotensin type 2 receptor activation by Zhao, Yi, Foryst‐Ludwig, Anna, Bruemmer, Dennis, Culman, Juraj, Bader, Michael, Unger, Thomas, Kintscher, Ulrich

“…The angiotensin type 2 (AT2) receptor has been previously demonstrated to exert neuroprotective actions possibly by inducing neuronal cell differentiation…”
Get full text

Contribution of bradykinin and nitric oxide to AT2 receptor‐mediated differentiation in PC12 W cells by Zhao, Yi, Biermann, Torsten, Luther, Claudia, Unger, Thomas, Culman, Juraj, Gohlke, Peter

“…We investigated the effect of angiotensin II on intracellular cyclic GMP content and neurite outgrowth as an indicator of cell differentiation in PC12 W cells…”
Get full text

Effects of orally applied candesartan cilexetil on central responses to angiotensin II in conscious rats by Gohlke, Peter, von Kügelgen, Sebastian, Jürgensen, Thomas, Kox, Thomas, Rascher, Wolfgang, Culman, Juraj, Unger, Thomas

“…OBJECTIVE In the present study, we investigated the ability of the peripherally administered angiotensin II type 1 (AT1) receptor antagonist, candesartan…”
Get full text

Effect of tachykinin receptor inhibition in the brain on cardiovascular and behavioral responses to stress by Culman, J, Klee, S, Ohlendorf, C, Unger, T

“…The neurokinins, substance P (SP) and neurokinin A (NKA) represent natural, nonspecific ligands of NK1 and NK2 receptors. In our study in conscious rats, we…”
Get more information

Central tachykinins: mediators of defence reaction and stress reactions by Culman, J, Unger, T

“…The tachykinins substance P, neurokinin A, and neurokinin B are natural agonists for NK1, NK2, and NK3 receptors, respectively. Evidence from biochemical,…”
Get more information

PSMA-617 inhibits proliferation and potentiates the 177Lu-PSMA-617-induced death of human prostate cancer cells by Zhao, Yi, Culman, Juraj, Cascorbi, Ingolf, Nithack, Niklas, Marx, Marlies, Zuhayra, Maaz, Lützen, Ulf

“…The human prostate–specific membrane antigen (PSMA) is substantially up-regulated in metastatic prostate cancer (PCa) cells. PSMA can be targeted by 177 Lu…”
Get full text

PPAR-γ: therapeutic target for ischemic stroke by Culman, Juraj, Zhao, Yi, Gohlke, Peter, Herdegen, Thomas

“…The peroxisome proliferator activated receptors (PPARs), which belong to the nuclear receptor superfamily, are key regulators of glucose and fat metabolism…”
Get full text

C-FOS expression in the rat brain in response to substance P and neurokinin B by Spitznagel, Heidi, Baulmann, Johannes, Blume, Annegret, Unger, Thomas, Culman, Juraj

“…Substance P, the principal neurokinin peptide in the mammalian brain and the natural ligand for the NK 1 tachykinin receptor, plays an integrative role in the…”
Get full text

Angiotensin AT1 receptor-mediated vasopressin release and drinking are potentiated by an AT2 receptor antagonist by HÖHLE, S, SPITZNAGEL, H, RASCHER, W, CULMAN, J, UNGER, T

“…Stimulation of angiotensin II AT2 receptors has been shown to inhibit AT1 receptor-mediated actions in peripheral tissues. The role of AT2 receptors in the…”
Get full text

PSMA-617 inhibits proliferation and potentiates the 177 Lu-PSMA-617-induced death of human prostate cancer cells by Zhao, Yi, Culman, Juraj, Cascorbi, Ingolf, Nithack, Niklas, Marx, Marlies, Zuhayra, Maaz, Lützen, Ulf

“…The human prostate-specific membrane antigen (PSMA) is substantially up-regulated in metastatic prostate cancer (PCa) cells. PSMA can be targeted by Lu…”
Get full text

Treatment of rats with pioglitazone in the reperfusion phase of focal cerebral ischemia: A preclinical stroke trial by Culman, Juraj, Nguyen-Ngoc, Miriam, Glatz, Torben, Gohlke, Peter, Herdegen, Thomas, Zhao, Yi

“…Thiazolidinediones (TZDs), pioglitazone, rosiglitazone and troglitazone, the synthetic agonists for the PPARγ, administered prior or during ischemic insult…”
Get full text

Pioglitazone induces cell growth arrest and activates mitochondrial apoptosis in human uterine leiomyosarcoma cells by a peroxisome proliferator-activated receptor γ-independent mechanism by Lützen, Ulf, Zhao, Yi, Lucht, Katja, Zuhayra, Maaz, Marx, Marlies, Cascorbi, Ingolf, Culman, Juraj

“…The peroxisome proliferator-activated receptor γ (PPARγ) agonists, thiazolidinediones, including pioglitazone (PIO) exhibit anti-tumour activities in cancer…”
Get full text

The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria by Zhao, Yi, Spigolon, Giada, Bonny, Christophe, Culman, Juraj, Vercelli, Alessandro, Herdegen, Thomas

“…Kainic acid (KA) induced seizures provokes an extensive neuronal degeneration initiated by c-Jun N-terminal kinases (JNK) as central mediators of…”
Get full text