Search Results - "Culler, M. D"

Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy by Jaquet, P, Gunz, G, Saveanu, A, Dufour, H, Taylor, J, Dong, J, Kim, S, Moreau, J-P, Enjalbert, A, Culler, M D

“…Objective: This study compared the potency of a somatostatin receptor (sstr)2–sstr5 analog, BIM-23244, of an sstr2-dopamine D2 receptor (sstr2-DAD2) molecule,…”
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Demonstration of Enhanced Potency of a Chimeric Somatostatin-Dopamine Molecule, BIM-23A387, in Suppressing Growth Hormone and Prolactin Secretion from Human Pituitary Somatotroph Adenoma Cells by Saveanu, A., Lavaque, E., Gunz, G., Barlier, A., Kim, S., Taylor, J. E., Culler, M. D., Enjalbert, A., Jaquet, P.

“…In acromegaly, the combination of somatostatin (SS) and dopamine (DA) agonists has been shown to enhance suppression of GH secretion. In the present study, a…”
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Somatostatin Dramatically Stimulates Growth Hormone Release from Primate Somatotrophs Acting at Low Doses Via Somatostatin Receptor 5 and Cyclic AMP by Córdoba-Chacón, J., Gahete, M. D., Culler, M. D., Castaño, J. P., Kineman, R. D., Luque, R. M.

“…Somatostatin and cortistatin have been shown to act directly on pituitary somatotrophs to inhibit growth hormone (GH) release. However, previous results from…”
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Somatostatin Inhibits Tumor Angiogenesis and Growth via Somatostatin Receptor-3-Mediated Regulation of Endothelial Nitric Oxide Synthase and Mitogen-Activated Protein Kinase Activities by Florio, T, Morini, M, Villa, V, Arena, S, Corsaro, A, Thellung, S, Culler, M. D, Pfeffer, U, Noonan, D. M, Schettini, G, Albini, A

“…Somatostatin was reported to inhibit Kaposi’s sarcoma (KS) cell (KS-Imm) xenografts through an antiangiogenic activity. Here, we show that somatostatin blocks…”
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Somatostatin and dopamine receptor interaction in prostate and lung cancer cell lines by Arvigo, M, Gatto, F, Ruscica, M, Ameri, P, Dozio, E, Albertelli, M, Culler, M D, Motta, M, Minuto, F, Magni, P, Ferone, D

“…Somatostatin analogues inhibit in vitro cell proliferation via specific membrane receptors (SSTRs). Recent studies on transfected cell lines have shown a…”
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Endogenous Ghrelin Regulates Episodic Growth Hormone (GH) Secretion by Amplifying GH Pulse Amplitude: Evidence from Antagonism of the GH Secretagogue-R1a Receptor by Zizzari, P, Halem, H, Taylor, J, Dong, J. Z, Datta, R, Culler, M. D, Epelbaum, J, Bluet-Pajot, M. T

“…Ghrelin was purified from rat stomach as an endogenous ligand for the GH secretagogue (GHS) receptor. As a GHS, ghrelin stimulates GH release, but it also has…”
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BIM-23244, a somatostatin receptor subtype 2- and 5-selective analog with enhanced efficacy in suppressing growth hormone (GH) from octreotide-resistant human GH-secreting adenomas by SAVEANU, A, GUNZ, G, DUFOUR, H, CARON, P, FINA, F, OUAFIK, L, CULLER, M. D, MOREAU, J. P, ENJALBERT, A, JAQUET, P

“…Although both somatostatin receptor subtype 2 (SSTR2) and SSTR5 messenger ribonucleic acid (mRNA) are consistently expressed in GH-secreting adenomas, SSTR2…”
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Characterization and sub-cellular localization of SS1R, SS2R, and SS5R in human late-stage prostate cancer cells: Effect of mono- and bi-specific somatostatin analogs on cell growth by Ruscica, M., Magni, P., Steffani, L., Gatto, F., Albertelli, M., Rametta, R., Valenti, L., Ameri, P., Magnaghi, V., Culler, M.D., Minuto, F., Ferone, D., Arvigo, M.

“…•Somatostatin system plays a significant role in the progression of human prostate cancer.•Activation of SS1R and SS2R/SS5R leads to relevant antiproliferative…”
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Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis by Tabarin, A., Diz-Chaves, Y., Consoli, D., Monsaingeon, M., Bale, T. L., Culler, M. D., Datta, R., Drago, F., Vale, W. W., Koob, G. F., Zorrilla, E. P., Contarino, A.

“…The actions of corticotropin‐releasing factor (CRF) and related peptides are mediated by two receptors (CRF1 and CRF2). The respective role of each subtype in…”
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Human somatostatin receptor subtypes in acromegaly : Distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes by JAQUET, P, SAVEANU, A, GUNZ, G, FINA, F, ZAMORA, A. J, GRINO, M, CULLER, M. D, MOREAU, J. P, ENJALBERT, A, OUAFIK, L. H

“…Recently, studies using somatostatin (SRIF) analogs preferential for either the SRIF receptor 2 (SSTR2) or the SSTR5 subtype demonstrated a variable…”
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The effect of emulsifying salts on the turbidity of a diluted milk system with varying pH and protein concentration by Culler, M D, Saricay, Y, Harte, F M

“…Solutions of 10 commonly used emulsifying salts (ES) listed in the Code of Federal Regulations (21CFR133.179) for pasteurized process cheese were tested for…”
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Quantitative and Functional Expression of Somatostatin Receptor Subtypes in Human Prolactinomas by Jaquet, P, Ouafik, L, Saveanu, A, Gunz, G, Fina, F, Dufour, H, Culler, M D, Moreau, J P, Enjalbert, A

“…ABSTRACTRecently, it was demonstrated that somatostatin analogs preferential for the SSTR5 subtype suppress PRL release from prolactinoma cell cultures by…”
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Somatostatin-dopamine chimeras: a novel approach to treatment of neuroendocrine tumors by Culler, M D

“…A combination of basic research observations concerning the interaction of somatostatin (SST) and dopamine (DA) receptors, and clinical reports of enhanced…”
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Characterization of New Selective Somatostatin Receptor Subtype-2 (sst2) Antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH Release in Anesthetized Male Rats after Short-Term High-Dose Dexamethasone Treatment by Tulipano, G, Soldi, D, Bagnasco, M, Culler, M. D, Taylor, J. E, Cocchi, D, Giustina, A

“…We here report a pharmacological characterization of two new somatostatin (SS) receptor subtype-2 (sst2) selective antagonists by evaluating their GH-releasing…”
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Dopamine receptor subtype 2 and somatostatin receptor subtype 5 expression influences somatostatin analogs effects on human somatotroph pituitary adenomas in vitro by Zatelli, M C, Piccin, D, Tagliati, F, Bottoni, A, Ambrosio, M R, Margutti, A, Scanarini, M, Bondanelli, M, Culler, M D, Uberti, E C degli

“…Dopamine (DA) and somatostatin (SRIF) receptor agonists inhibit growth hormone (GH) secretion by pituitary adenomas. We investigated DA subtype 2 receptor…”
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Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone, and prolactin regulation by Shimon, I, Taylor, J E, Dong, J Z, Bitonte, R A, Kim, S, Morgan, B, Coy, D H, Culler, M D, Melmed, S

“…Somatostatin (SRIF), a hypothalamic inhibitor of pituitary growth hormone (GH) and thyroid-stimulating hormone (TSH) secretion, binds to five distinct receptor…”
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Novel ghrelin analogs with improved affinity for the GH secretagogue receptor stimulate GH and prolactin release from human pituitary cells by Rubinfeld, H, Hadani, M, Taylor, JE, Dong, JZ, Comstock, J, Shen, Y, Deoliveira, D, Datta, R, Culler, MD, Shimon, I

“…OBJECTIVE: Ghrelin, a recently identified 28-amino acid peptide is a potent GH secretagogue (GHS) produced predominantly by the stomach. Ghrelin stimulates GH…”
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Regulation of insulin and glucagon secretion from rat pancreatic islets in vitro by somatostatin analogues by Ludvigsen, E., Stridsberg, M., Taylor, J.E., Culler, M.D., Öberg, K., Janson, E.T., Sandler, S.

“…Somatostatin is an inhibitor of hormone secretion through specific receptors (sst 1–5). The aim of this study was to investigate the putative regulatory role…”
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The effect of selective sst1, sst2, sst5 somatostatin receptors agonists, a somatostatin/dopamine (SST/DA) chimera and bromocriptine on the “clinically non-functioning” pituitary adenomas in vitro by Gruszka, A., Kunert-Radek, J., Radek, A., Pisarek, H., Taylor, J., Dong, J.Z., Culler, M.D., Pawlikowski, M.

“…The aim of the work was to investigate the effects of somatostatin analogs acting selectively on sst1 (BIM-23926), sst2 (BIM-23120) and sst5 (BIM-23206)…”
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Expression and function of somatostatin receptor subtype 1 in human growth hormone secreting pituitary tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs by Matrone, C, Pivonello, R, Colao, A, Cappabianca, P, Cavallo, L M, Del Basso De Caro, M L, Taylor, J E, Culler, M D, Lombardi, G, Di Renzo, G F, Annunziato, L

“…The role of somatostatin (SS) receptor subtype 1 (SSTR(1)) in mediating the inhibitory effect of SS on growth hormone (GH) secreting pituitary tumors has been…”
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