Search Results - "Cullen, Paul"

Gene by Environment Interactions reveal new regulatory aspects of signaling network plasticity by Vandermeulen, Matthew D, Cullen, Paul J

“…Phenotypes can change during exposure to different environments through the regulation of signaling pathways that operate in integrated networks. How signaling…”
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Regulation of Cdc42 protein turnover modulates the filamentous growth MAPK pathway by González, Beatriz, Cullen, Paul J

“…Rho GTPases are central regulators of cell polarity and signaling. How Rho GTPases are directed to function in certain settings remains unclear. Here, we show…”
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The regulation of filamentous growth in yeast by Cullen, Paul J, Sprague, Jr, George F

“…Filamentous growth is a nutrient-regulated growth response that occurs in many fungal species. In pathogens, filamentous growth is critical for host-cell…”
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Metabolic respiration induces AMPK- and Ire1p-dependent activation of the p38-Type HOG MAPK pathway by Adhikari, Hema, Cullen, Paul J

“…Evolutionarily conserved mitogen activated protein kinase (MAPK) pathways regulate the response to stress as well as cell differentiation. In Saccharomyces…”
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Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition by Kumar, Rohitashw, Breindel, Christine, Saraswat, Darpan, Cullen, Paul J., Edgerton, Mira

“…Candida albicans is an opportunistic fungal pathogen colonizing the oral cavity. C . albicans secreted aspartic protease Sap6 is important for virulence during…”
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Chaperone-Dependent Degradation of Cdc42 Promotes Cell Polarity and Shields the Protein from Aggregation by González, Beatriz, Aldea, Martí, Cullen, Paul J.

“…Rho GTPases are global regulators of cell polarity and signaling. By exploring the turnover regulation of the yeast Rho GTPase Cdc42p, we identified new…”
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Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation by Vandermeulen, Matthew D, Lorenz, Michael C, Cullen, Paul J

“…Eukaryotic organisms are composed of different cell types with defined shapes and functions. Specific cell types are produced by the process of cell…”
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Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis by Puri, Sumant, Kumar, Rohitashw, Chadha, Sonia, Tati, Swetha, Conti, Heather R, Hube, Bernhard, Cullen, Paul J, Edgerton, Mira

“…Perception of external stimuli and generation of an appropriate response are crucial for host colonization by pathogens. In pathogenic fungi, mitogen activated…”
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New Aspects of Invasive Growth Regulation Identified by Functional Profiling of MAPK Pathway Targets in Saccharomyces cerevisiae by Vandermeulen, Matthew D, Cullen, Paul J

“…Abstract MAPK pathways are universal regulators of morphogenesis and stress responses in eukaryotes. In this study, Vandermeulen and Cullen identified the…”
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Spatiotemporal control of pathway sensors and cross-pathway feedback regulate a differentiation MAPK pathway in yeast by Prabhakar, Aditi, González, Beatriz, Dionne, Heather, Basu, Sukanya, Cullen, Paul J

“…Mitogen-activated protein kinase (MAPK) pathways control cell differentiation and the response to stress. In Saccharomyces cerevisiae, the MAPK pathway that…”
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Regulation of intrinsic polarity establishment by a differentiation-type MAPK pathway in S. cerevisiae by Prabhakar, Aditi, Chow, Jacky, Siegel, Alan J, Cullen, Paul J

“…All cells establish and maintain an axis of polarity that is critical for cell shape and progression through the cell cycle. A well-studied example of polarity…”
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Turnover and Bypass of p21-Activated Kinase During Cdc42-Dependent MAPK Signaling in Yeast by González, Beatriz, Mirzaei, Mahnoosh, Basu, Sukanya, Pujari, Atindra N., Vandermeulen, Matthew D., Prabhakar, Aditi, Cullen, Paul J.

“…Mitogen-activated protein kinase (MAPK) pathways regulate multiple cellular behaviors, including the response to stress and cell differentiation, and are…”
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The filamentous growth MAPK Pathway Responds to Glucose Starvation Through the Mig1/2 transcriptional repressors in Saccharomyces cerevisiae by Karunanithi, Sheelarani, Cullen, Paul J

“…In the budding yeast S. cerevisiae, nutrient limitation induces a MAPK pathway that regulates filamentous growth and biofilm/mat formation. How nutrient levels…”
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Proteins That Interact with the Mucin-Type Glycoprotein Msb2p Include a Regulator of the Actin Cytoskeleton by Prabhakar, Aditi, Vadaie, Nadia, Krzystek, Thomas, Cullen, Paul J

“…Transmembrane mucin-type glycoproteins can regulate signal transduction pathways. In yeast, signaling mucins regulate mitogen-activated protein kinase (MAPK)…”
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Bypass of Candida albicans Filamentation/Biofilm Regulators through Diminished Expression of Protein Kinase Cak1 by Woolford, Carol A, Lagree, Katherine, Xu, Wenjie, Aleynikov, Tatyana, Adhikari, Hema, Sanchez, Hiram, Cullen, Paul J, Lanni, Frederick, Andes, David R, Mitchell, Aaron P

“…Biofilm formation on implanted medical devices is a major source of lethal invasive infection by Candida albicans. Filamentous growth of this fungus is tied to…”
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A Rab escort protein regulates the MAPK pathway that controls filamentous growth in yeast by Jamalzadeh, Sheida, Pujari, Atindra N., Cullen, Paul J.

“…MAPK pathways regulate different responses yet can share common components. Although core regulators of MAPK pathways are well known, new pathway regulators…”
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Modulators of MAPK pathway activity during filamentous growth in Saccharomyces cerevisiae by Pujari, Atindra N, Cullen, Paul J

“…Mitogen-activated protein kinase (MAPK) pathways control the response to intrinsic and extrinsic stimuli. In the budding yeast Saccharomyces cerevisiae, cells…”
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Candida albicans biofilm development is governed by cooperative attachment and adhesion maintenance proteins by McCall, Andrew D., Pathirana, Ruvini U., Prabhakar, Aditi, Cullen, Paul J., Edgerton, Mira

“…The opportunistic fungal pathogen Candida albicans is capable of adhering to the oral mucosa despite forces created by salivary flow. Although many fungal…”
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Co(II) Macrocyclic Complexes Appended with Fluorophores as paraCEST and cellCEST Agents by Patel, Akanksha, Abozeid, Samira M, Cullen, Paul J, Morrow, Janet R

“…Four high-spin macrocyclic Co­(II) complexes with hydroxypropyl or amide pendants and appended coumarin or carbostyril fluorophores were prepared as CEST…”
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Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans by Saraswat, Darpan, Kumar, Rohitashw, Pande, Tanaya, Edgerton, Mira, Cullen, Paul J.

“…Summary Temperature is a potent inducer of fungal dimorphism. Multiple signalling pathways control the response to growth at high temperature, but the sensors…”
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